A5101823003- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Breast Implant and Reconstruction
- HER2/EGFR in Cancer Research
- Global Cancer Incidence and Screening
- Cancer and Skin Lesions
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- BRCA gene mutations in cancer
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- Salivary Gland Tumors Diagnosis and Treatment
- Optical Imaging and Spectroscopy Techniques
- Cancer Diagnosis and Treatment
- MRI in cancer diagnosis
- Economic and Financial Impacts of Cancer
- Reconstructive Surgery and Microvascular Techniques
- Medical Imaging Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Spectroscopy Techniques in Biomedical and Chemical Research
- Photoacoustic and Ultrasonic Imaging
- Colorectal Cancer Surgical Treatments
- Multiple and Secondary Primary Cancers
- Cell Image Analysis Techniques
Cedars-Sinai Medical Center
2016-2025
Saint John's Health Center
2010-2014
Singapore General Hospital
2009
Memorial Sloan Kettering Cancer Center
2008
University of California, Los Angeles
2008
Breast cancer affects one in eight women their lifetime. Though diet, age and genetic predisposition are established risk factors, the majority of breast cancers have unknown etiology. The human microbiota refers to collection microbes inhabiting body. Imbalance microbial communities, or dysbiosis, has been implicated various diseases including obesity, diabetes, colon cancer. Therefore, we investigated potential role by next-generation sequencing using tumor tissue paired normal adjacent...
In Brief Objective: B7 ligand family members have been shown to be important immunoregulatory factors in host tumor immune responses. We hypothesized that B7–H3, a coinhibitory factor, is expressed by primary breast cancer cells and associated with metastasis regional tumor-draining lymph nodes. Experimental Design: American Joint Committee on Cancer stage I III cancers (n = 82) normal specimens 17) were assessed for B7–H3 expression using paraffin-embedded archival tissues. was quantitative...
The aggressive triple-negative phenotype of breast cancer (negative for estrogen and progesterone receptors v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 [ERBB2] [formerly human epidermal growth factor receptor (HER2)]) is considered by some investigators to be a relative contraindication breast-conserving therapy.To compare outcomes therapy patients with (TNBC) those the luminal A, B, ERBB2 subtypes.Prospective database review at an academic tertiary medical center...
Background Radioactive seed localization (RSL) and the Savi scout® radar (SSR) are newer alternatives to wire-guided (WL) for nonpalpable breast lesions. Objective To compare three types of devices used in conserving surgery. Methods A total 293 patients had a partial mastectomy (n = 194) or biopsy 99) with preoperative image-guided single lesion between July 2017 2018. Lesions were localized by WL, RSL, SSR. Although all operations performed outpatient, due workflow differences at our...
Abstract Background National guidelines recommend omitting SNB in older patients with favorable invasive breast cancer. However, there is a lack of prospective data specifically addressing this issue. This study evaluates recurrence and survival estrogen receptor-positive/Her2− (ER+) cancer patients, aged ≥ 65 years who have breast-conserving surgery (BCS) without SNB. Methods prospective, observational at single institution where 125 clinical T1-2N0 ER+ undergoing BCS were enrolled....
CCN1 plays diverse roles in cellular proliferation, survival, migration and angiogenesis. We determined the relationship between protein expression clinical factors that are important for classification of breast cancer. contains four functional domains; contribution each structural domains to biological properties cancer was investigated. performed immunohistochemistry on a tissue array, conducted detailed statistical analysis The structure-function examined using mutant constructs which...
Abstract: Accurate determination of the size or extent ductal carcinoma in situ (DCIS) by imaging is uncertain, and incomplete resection tumor results involved margins up to 81% cases. This study examined accuracy magnetic resonance (MRI) for assessment DCIS size, evaluated effect preoperative breast MRI on achievement tumor-free surgical after breast-conserving surgery (BCS). One-hundred fifty-eight female patients with were identified from a prospective database: 60 (62 cases) had MRI, 98...
The American College of Surgeons Oncology Group Z0011 (ACOSOG Z0011) trial demonstrated no survival advantage for women with clinical T1–T2 invasive breast cancer 1–2 positive sentinel lymph nodes (SLN) who received whole-breast radiation, and further axillary surgery when compared to did undergo node dissection (ALND). We used the National Cancer Database (NCDB) study changes in utilization ALND after publication this trial. NCDB was queried female patients from 2012 2015 met criteria....
<h3>Hypothesis</h3> Fludeoxyglucose F 18 (FDG) positron emission tomography (PET) can be used to predict axillary node metastases. <h3>Design</h3> Case series. <h3>Setting</h3> Comprehensive breast care center. <h3>Patients</h3> Fifty-one women with 54 biopsy-proven invasive cancers. <h3>Intervention</h3> Whole-body FDG-PET performed before surgery and interpreted blindly. <h3>Main Outcome Measures</h3> Axillary FDG activity, quantified by standardized uptake value (SUV); metastases,...
Immune cell infiltrates (ICI) of tumors are scored by pathologists around tumor glands. To obtain a better understanding the immune infiltrate, individual types, their activation states and location relative to cells need be determined. This process requires precise identification area enumeration subtypes separately in stroma inside nests. Such measurements can accomplished multiplex format using immunohistochemistry (IHC). We developed pipeline that combines (IHC) digital image analysis....
Abstract Background We investigate whether optical imaging can reliably detect abnormalities in tissue, a range of specimens (live cells vitro; fixed, fresh ex‐vivo and vivo tissue), without the use added contrast agents, review our promising spectral methods for achieving quantitative, real‐time, high resolution intrasurgical diagnostics. Methods reflectance, fluorescence, two‐photon, Mie scattering imaging, performed with instrumentation we developed or modified, to intrinsic tissue...