A5022683685- Cardiac Arrest and Resuscitation
- Trauma and Emergency Care Studies
- Breast Implant and Reconstruction
- Cardiac, Anesthesia and Surgical Outcomes
- Breast Cancer Treatment Studies
- Emergency and Acute Care Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Healthcare cost, quality, practices
- Health Systems, Economic Evaluations, Quality of Life
- Appendicitis Diagnosis and Management
- Healthcare Policy and Management
- Protease and Inhibitor Mechanisms
- Patient Safety and Medication Errors
- Hospital Admissions and Outcomes
- Anesthesia and Pain Management
- Palliative Care and End-of-Life Issues
- Esophageal Cancer Research and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Asthma and respiratory diseases
- Esophageal and GI Pathology
- Intestinal Malrotation and Obstruction Disorders
- Family and Patient Care in Intensive Care Units
- Global Cancer Incidence and Screening
- Abdominal Trauma and Injuries
- Pain Management and Opioid Use
Cedars-Sinai Medical Center
2010-2024
University of California, Los Angeles
2019
Morehouse School of Medicine
2018
Orlando Regional Medical Center
2014-2016
American Association for the Surgery of Trauma
2015
Orlando Health
2013-2014
Brigham and Women's Hospital
2009
UCLA Medical Center
2002-2003
Harbor–UCLA Medical Center
2002-2003
National Polytechnic School
1970
Abstract Activin A, a homodimeric protein (βAβA) and member of the TGF-β superfamily, is involved in inflammatory repair process. Using cDNA microarray analysis, we discovered strong induction activin βA gene human mast cells (MC) on stimulation with PMA calcium ionophore (A23187). mRNA was also highly induced primary cultured murine bone marrow MC (BMMC) after by IgE receptor cross-linking. Secretion A evident cell-1 line 3 h progressively increased over time. present cytoplasm activated...
BACKGROUND β-Adrenergic receptor blockers (BBs) administered after trauma blunt the cascade of immune and inflammatory changes associated with injury. BBs are improved outcomes traumatic brain injury (TBI). Propranolol may be an ideal BB because its nonselective inhibition ability to cross blood-brain barrier. We determined if early administration propranolol TBI is lower mortality. METHODS All adults (age ≥ 18 years) moderate-to-severe (head Abbreviated Injury Scale [AIS] score, 3–5)...
Although obesity has been proposed as a risk factor for adverse outcomes after trauma, numerous studies report conflicting results. The objective of this study was to compare obese and nonobese patients trauma. population consisted all trauma admitted surgical intensive care unit in Level I center from January 1999 December 2002. Admission data, demographics, injury severity score (ISS), illness, hospital course, complications, were compared between (OB; body mass index [BMI] > or = 30),...
Increasing evidence indicates insurance status plays a role in the outcome of trauma patients; however its on outcomes after traumatic brain injury (TBI) remains unclear. A retrospective review was queried within National Trauma Data Bank. Moderate to severe TBI insured patients were compared with their uninsured counterparts respect demographics, Injury Severity Score, Glasgow Coma Scale score, and outcome. Multivariate logistic regression analysis used determine independent risk factors...
This study aims to determine whether severity-adjusted outcomes including mortality are adversely impacted by readmission a surgical intensive care unit (SICU) during the same hospital stay.The included all patients admitted 20-bed tertiary SICU in an urban teaching Level I trauma center and multiorgan transplant from January 1, 1996 December 31, 2001. was prospective observational with secondary data analysis. Acute Physiology Chronic Health Evaluation (APACHE II) Simplified (SAPS) severity...
Animal studies routinely demonstrate an alcohol (ETOH) -mediated increase in survival after experimental traumatic brain injury (TBI). Recent clinical also suggest ETOH plays a neuroprotective role moderate to severe TBI. We sought investigate the relationship between and outcomes patients with TBI using countywide database. The Los Angeles County Trauma System database was queried for all adult (older than 14 years) isolated trauma (head Abbreviated Injury Score [AIS] 3 or greater, other...
Pain associated with rib fractures impairs respiratory function and increases pulmonary morbidity. The purpose of this study was to determine how epidural catheters alter mortality complications in trauma patients. We performed a retrospective involving adult blunt patients moderate-to-severe injuries from January 1, 2004 December 31, 2013. During the 10-year period, 526 met inclusion criteria; 43/526 (8%) had catheter placed. Mean age (CATH) higher compared without (NOCATH) (54 vs 48 years,...
Ten patients conforming to a diagnosis of cretinism have been studied. These live in an area rural Ecuador where endemic goiter is severe. Diagnosis was based on severe mental retardation, shortness stature and constellation findings considered characteristics this disorder. The were not clinically hypothyroid. Serum hormone measurements low normal; radioiodine uptake values high. Major abnormalities encountered osseous development, hearing electroencephalographic activity. Most had...
The American College of Surgeons Oncology Group Z0011 (ACOSOG Z0011) trial demonstrated no survival advantage for women with clinical T1–T2 invasive breast cancer 1–2 positive sentinel lymph nodes (SLN) who received whole-breast radiation, and further axillary surgery when compared to did undergo node dissection (ALND). We used the National Cancer Database (NCDB) study changes in utilization ALND after publication this trial. NCDB was queried female patients from 2012 2015 met criteria....
Field intubation (FI) by emergency medical service personnel on severely injured trauma patients remains a contentious practice. Clinical studies suggest an association between FI and adverse outcomes in with traumatic brain injury. Military tactical casualty care recommends deferring providing supplemental oxygenation until reaching more equipped destination. In addition, animal models penetrating hemorrhagic shock demonstrate increased acidosis before resuscitation. The purpose of this...
Introduction: Small bowel obstruction (SBO) is a common cause of hospital admission leading to resource utilization. The majority these patients require non-operative management (NOM) which can lead increased length stay (LOS), readmissions, utilization, and throughput delays. Early surgical consultation (SC) for SBO may improve efficiency outcomes. Methods: We implemented an institution-wide intervention (INT) encourage early SC (<1 day diagnosis) in July 2022. A retrospective analysis...
The obese state has been linked to several immune-mediated conditions. Our objective was examine the association of body mass index (BMI) with diagnosis heparin-induced thrombocytopenia (HIT).Prospectively collected data on patients in surgical and cardiac intensive care unit suspected having HIT between January 2007 August 2014 were analyzed. Patients categorized into five discrete BMI (kg/m) groups compared. Data included Warkentin 4-T scores, antiplatelet factor 4 (anti-PF4OD) values,...
Surgical intervention for ischemic colitis is associated with significant postoperative morbidity and mortality. Predictive factors of adverse outcomes have been reported in the literature, but are based on small sample populations. We sought to identify risk mortality after emergent colectomy using a clinical database.The American College Surgeons National Quality Improvement Project database was queried from 2010 2015 colectomies performed Current Procedural Terminology International...