A5014960791- Radiomics and Machine Learning in Medical Imaging
- Neuroscience and Neuropharmacology Research
- Neurosurgical Procedures and Complications
- Pharmaceutical studies and practices
- Skin Diseases and Diabetes
- Intracranial Aneurysms: Treatment and Complications
- Receptor Mechanisms and Signaling
- Molecular Sensors and Ion Detection
- Drug-Induced Adverse Reactions
- Histiocytic Disorders and Treatments
- Autoimmune and Inflammatory Disorders
- Pharmacology and Obesity Treatment
- Autoimmune Bullous Skin Diseases
- Neurological Disorders and Treatments
- AI in cancer detection
- Inflammatory Myopathies and Dermatomyositis
- Artificial Intelligence in Healthcare and Education
- Traumatic Brain Injury and Neurovascular Disturbances
- Pharmacogenetics and Drug Metabolism
- Parvovirus B19 Infection Studies
- Nail Diseases and Treatments
- Phytochemistry and biological activities of Ficus species
- Retinal and Macular Surgery
- Single-cell and spatial transcriptomics
- Melanoma and MAPK Pathways
Yale University
1978-2025
Neurology, Inc
2025
Cedars-Sinai Medical Center
2024
Yale New Haven Hospital
2022
Health First
2022
American Academy of Dermatology
2022
Novartis (Switzerland)
1989-1993
Connecticut Mental Health Center
1978
University of California, Los Angeles
1975
Abstract —The kinetics of plasma choline (Ch) and the uptake Ch into brain were studied by means intravenous infusion [ 2 H 4 ]Ch at various rates anaesthetized conscious rats. levels in both arterial venous steady state linearly related to rate; however, unlabelled independent rate. higher than plasma, while plasma. It was concluded that is being generated released effluent. The supply not decreased if level increased. clearance turnover compartment its initial distribution are 75 ml kg ‐1...
Deep learning (DL) models have rapidly become a popular and cost-effective tool for image classification within oncology. A major limitation of DL is their vulnerability to adversarial images, manipulated input images designed cause misclassifications by models. The purpose the study investigate robustness trained on diagnostic using explore utility an iterative training approach improve against images.We examined impact accuracies classify cancerous lesions across three common oncologic...
Ab~tract-[~H,]Ch (2 pmol kg- 'min- I) was infused into both anaesthetized and conscious rats to study the kinetics of plasma brain choline (Ch) acetylcholine (ACh). A larger amount endogenous Ch found leave than enter, even in animals. ['H,]Ch taken up where a portion converted ['H4]ACh. Upon stopping infusion, however, more indicating source capable generating which is labelled by infusion for 32 min. There appears, be one since post mortem increase not following prolonged infusion. Thus,...
Introduction: Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening condition after which patients are at risk for vasospasm and delayed cerebral ischemia (DCI). Nimodipine, calcium channel blocker, used to reduce the of DCI. Despite its widespread application, specific effects on hemodynamics cortical activity poorly characterized. It remains unknown whether this potent therapy may have unintended harmful consequences in some patients, could potentially be mitigated or avoided....
To compare long-term oncologic outcomes and adjuvant therapies for patients treated with transoral robotic surgery (TORS), nonrobotic surgery, or laser microsurgery (TLM).A retrospective analysis of the National Cancer Database (2010-2014).Patients clinical tumor (T)1 T2 oropharyngeal squamous cell carcinomas (OPSCC) were classified into those receiving TORS versus TLM. Univariate multivariate survival analyses conducted chi-square tests; Kaplan-Meier log-rank test; Cox multivariate,...
Hemicholinium (HC-3) causes a behavioral reactivity in rats which is correlated with the depletion of brain acetylcholine (ACh). The decrease ACh levels and effects caused by HC-3 are dose-dependent manner, maximal being achieved at an intraventricular (i.vt.) dose 1 microgram. concentration 2 hr after i.vt. injection does not increase further doses greater than 10 affect uptake choline (Ch) into subcellular fractions prepared from treated animals. areas studied closely parallels...
—The kinetics of plasma choline (Ch) and the uptake Ch into brain were studied by means intravenous infusion [2H4]Ch at various rates anaesthetized conscious rats. levels in both arterial venous steady state linearly related to rate; however, unlabelled independent rate. higher than plasma, while plasma. It was concluded that is being generated released effluent. The supply not decreased if level increased. clearance turnover compartment its initial distribution are 75 ml kg-1 min-1 716 nmol...
Abstract Purpose Deep learning (DL) models have rapidly become a popular and cost-effective tool for image classification within oncology. A major limitation of DL is output instability, as small perturbations in input data can dramatically alter model output. The purpose the study to investigate robustness oncologic domain through application adversarial images : manipulated with pixel-level designed assess stability models. Experimental Design We examined impact on accuracies trained...
Characterize the effects of intrathecal nicardipine (ITN) on cerebrovascular function as measured by cerebral autoregulation and cortical activity quantitative electroencephalography (qEEG) in aneurysmal subarachnoid hemorrhage (aSAH).
Abstract The effect of food on the pharmacokinetic disposition fadrozole hydrochloride was evaluated in nine healthy male and female volunteers. Single 12 mg doses were orally administered to subjects immediately following a standardized meal or after fasting for h, randomized crossover design. No statistically significant treatment differences detected parameters AUC half‐life. C max significantly reduced by 15% fed relative fasted treatment, t delayed 39%. These findings indicate that...
CGS 16617, a direct‐acting angiotensin‐converting‐enzyme inhibitor, was administered as single dose of 20 mg in aqueous solution to 12 healthy male volunteers on two occasions randomized, cross‐over design study. On one occasion, the after an overnight fast; other it subjects ate standard breakfast. Administration 16617 food associated with statistically significant decreases peak plasma concentrations (58%) and areas under concentration‐time curves (23%) compared drug administration fasted...
Radiation therapy (RT) has traditionally been disregarded in the primary or adjuvant treatment of renal cell carcinoma (RCC), but recent advances have necessitated a re-examination role radiation may be able to play. The advent stereotactic ablative radiotherapy (SABR), which allows for targeting disease with higher doses shorter window time, open up new avenues RT’s RCC, cancer relatively low alpha/beta ratio. Thus, this review examines both history and future RT RCC an aim expand...
Abstract Although deep learning analysis of diagnostic imaging has shown increasing effectiveness in modeling non-small cell lung cancer (NSCLC) outcomes, a minority proposed algorithms have been externally validated. Given majority these models are built on single institutional datasets, their generalizability across the entire population remains understudied. Moreover, effect biases that exist among training dataset overall prognostic is unclear. We attempted to identify demographic and...