A5004675513- RNA modifications and cancer
- Cancer Research and Treatments
- Galectins and Cancer Biology
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Medical Imaging and Pathology Studies
- Hereditary Neurological Disorders
- Cancer-related gene regulation
- Cell Adhesion Molecules Research
- Pregnancy and preeclampsia studies
- Advanced biosensing and bioanalysis techniques
- Glycosylation and Glycoproteins Research
- Glioma Diagnosis and Treatment
- Retinal and Macular Surgery
- Reproductive System and Pregnancy
- Hippo pathway signaling and YAP/TAZ
- Caveolin-1 and cellular processes
- Birth, Development, and Health
- Retinal Diseases and Treatments
- RNA Research and Splicing
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Neonatal Respiratory Health Research
University of California, Los Angeles
2016-2025
UCLA Jonsson Comprehensive Cancer Center
2010-2025
UCLA Health
2002-2025
Charles R. Drew University of Medicine and Science
2011-2024
Ronald Reagan UCLA Medical Center
2011-2022
Oxford University Press (United Kingdom)
2020
VA Greater Los Angeles Healthcare System
2014
Memorial Sloan Kettering Cancer Center
2010-2014
University of Buenos Aires
2014
UCLA Medical Center
2011-2013
Angiotropism/pericytic mimicry and vascular co-option involve tumor cell interactions with the abluminal surface. These two phenomena may be closely related. However, investigations of processes have developed in an independent fashion different explanations offered as to their biological nature. Angiotropism describes propensity cells spread distantly via continuous migration along surfaces, or extravascular migratory metastasis (EVMM). Vascular has been proposed alternative mechanism by...
The sensitivity of current surveillance methods for detecting early-stage hepatocellular carcinoma (HCC) is suboptimal. Extracellular vesicles (EVs) are promising circulating biomarkers early cancer detection. In this study, we aim to develop an HCC EV-based surface protein assay detection HCC.Tissue microarray was used evaluate four potential HCC-associated markers. An EV assay, composed covalent chemistry-mediated purification and real-time immuno-polymerase chain reaction readouts,...
Although approximately 98% of the internal surface area lung is lined by alveolar type I cells, little known about functions this cell type. Using freshly isolated rat and II we created a subtraction library suppression subtractive hybridization to identify genes differentially expressed cells. We identified twelve function that are Differential expression all 12 was confirmed Northern blotting; differential immunocytochemistry for 3 which suitable antibodies were available. Most code...
Manuka honey (MH) exhibits potential antitumor activity in preclinical models of a number human cancers. Treatment vitro with MH at concentrations ranging from 0.3 to 5.0% (
Understanding tumor-induced angiogenesis is a challenging problem with important consequences for the diagnosis and treatment of cancer. In this study, we define novel function epithelial membrane protein-2 (EMP2) in control angiogenesis. EMP2 functions as an oncogene endometrial cancer, its expression has been linked to decreased survival. Using cancer xenografts, modulation resulted profound changes tumor microvasculature. Under hypoxic conditions, upregulation promoted vascular...
Despite significant advances in biology and medicine, the incidence mortality due to breast cancer worldwide is still unacceptably high. Thus, there an urgent need discover new molecular targets. In this article, we show evidence for a novel target human cancer, tetraspan protein epithelial membrane protein-2 (EMP2). Using tissue tumor arrays, expression of EMP2 was measured found be minimal normal mammary tissue, but it upregulated 63% invasive tumors 73% triple-negative tested. To test...
Glioblastoma is a highly aggressive neoplasm and the most common primary malignant brain tumor. Endothelial tissue plays critical role in glioblastoma growth progression, facilitating angiogenesis, cellular communication, tumorigenesis. In this review, we present an up-to-date comprehensive summary of endothelial cells glioblastomas, along with overview recent developments therapies tumor marker identification.
INTRODUCTION: The role of Epithelial Membrane Protein-2 (EMP2) in mediating resistance to current anti-angiogenic drugs the treatment glioblastoma (GBM) is an intriguing hypothesis that may provide insights into improving limited survival benefits observed therapies. Investigating interaction between EMP2 and such as bevacizumab or Aflibercept could lead a better understanding mechanisms underlying resistance, potentially opening up new avenues for more effective strategies. METHODS: Tumor...
Abstract Therapeutic agents targeting tumor cells have a cytotoxic effect that primarily results in an apoptotic insult through numerous mechanisms. Recently, immune activation mechanisms directed against been identified as secondary of targeted therapy. In this mechanism, release ATP and various intracellular proteins into the intratumoral space including HSP70, HMGB1 calreticulin. These damage-associated molecular patterns (DAMPs) then decorate nearby undamaged where infiltrating host...
Abstract Breast cancer (BC) is the most common among women in U.S. It disproportionately affects African American (AA) who have earlier disease onset, more aggressive subtypes, and lower survival rates compared to European (EA) women. AA tumors show distinct gene variants linked poor BC outcomes immune signatures with differential expression of cytokines/chemokines potentially driving a immunosuppressive tumor microenvironment (TME). Of note, cancer-related inflammation promotes aberrant...
The growth arrest-specific-3 (GAS3)/PMP22 proteins are members of the four-transmembrane (tetraspan) superfamily. Although function these is poorly understood, GAS3/PMP22 have been implicated in control and progression certain cancers. Epithelial membrane protein-2 (EMP2), a family member, was recently identified as putative tumor suppressor gene. Here, we addressed normal EMP2 by testing prediction that it influences integrin-related cell functions. We observed associates with β1 integrin...
Endometrial cancer is the most common gynecologic malignancy diagnosed among women in developed countries. One recent biomarker strongly associated with disease progression and survival epithelial membrane protein-2 (EMP2), a tetraspan protein known to associate modify surface expression of certain integrin isoforms. In this study, we show using xenograft model system that EMP2 necessary for efficient endometrial tumor formation, have started characterize mechanism by which contributes...
We hypothesize that the interaction between angiotropic melanoma cells and abluminal vascular surface can induce or sustain embryonic and/or stem cell migratory properties in these tumor cells. As a result, such may migrate along surface, demonstrating pericytic mimicry. Through cellular interactions, toward secondary sites.
Epithelial membrane protein-2 (EMP2) is upregulated in a number of tumors and therefore remains promising target for mAb-based therapy. In the current study, image-guided therapy an anti-EMP2 mAb was evaluated by PET both syngeneic immunodeficient cancer models expressing different levels EMP2 to enable better understanding its tumor uptake off accumulation clearance. The therapeutic efficacy initially high- low-expressing tumors, reduced load high EMP2-expressing 4T1 HEC-1-A tumors. To...
Air pollution (AP) is detrimental to pregnancies including increasing risk factors of gestational diabetes mellitus. We hypothesized that exposure AP causes cardiovascular and metabolic disruption thereby altering placental gene expression, which in turn affects the phenotype embryonic/fetal development. To test this hypothesis, we investigated impact intra-nasal instilled upon day 16-19 maternal mouse status, nutrient transporters, placental-fetal size morphology. further unravel...
Abstract BACKGROUND Epithelial membrane protein 2 (EMP2) is an estrus‐regulated tetraspan that required for endometrial competence in blastocyst implantation. EMP2 controls surface levels of several classes integrin and other cell‐interaction molecules, their trafficking to glycolipid‐enriched lipid raft domains important receptor signaling. These features suggest may contribute neoplastic traits cancer. The objective this study was determine the prevalence expression neoplasms its clinical...
purpose. Proliferative vitreoretinopathy (PVR) occurs in approximately 10% of patients after retinal detachment. PVR results from a multiphase process that leads to an aberrant wound-healing strategy with contractile cellular forces and tractional detachment (TRD). Epithelial membrane protein (EMP) 2 controls cell surface expression function integrin isoforms associated contraction many types. Since EMP2 is highly expressed pigment epithelium, this study investigates the role collagen gel...
Abstract Purpose: The tetraspan protein epithelial membrane protein-2 (EMP2) has been shown to regulate the surface display and signaling from select integrin pairs, it was recently identified as a prognostic biomarker in human endometrial cancer. In this study, we assessed role of EMP2 ovarian Experimental Design: We examined expression within population women with cancer using tissue microarray assay technology. evaluated efficacy EMP2-directed antibody therapy fully recombinant bivalent...