A5100701202- Proteoglycans and glycosaminoglycans research
- Multi-Criteria Decision Making
- Ion Transport and Channel Regulation
- Cancer-related molecular mechanisms research
- Helicobacter pylori-related gastroenterology studies
- Cell Adhesion Molecules Research
- Gut microbiota and health
- Angiogenesis and VEGF in Cancer
- Glycosylation and Glycoproteins Research
- Rough Sets and Fuzzy Logic
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Wnt/β-catenin signaling in development and cancer
- RNA modifications and cancer
- Drug Transport and Resistance Mechanisms
- Fuzzy Systems and Optimization
- Genomics and Chromatin Dynamics
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
- Error Correcting Code Techniques
- Advanced Data Storage Technologies
- Evaluation Methods in Various Fields
- Optimization and Mathematical Programming
- Inflammatory Bowel Disease
- Hippo pathway signaling and YAP/TAZ
China Pharmaceutical University
2025
Huazhong University of Science and Technology
2016-2025
Tongji Hospital
2016-2025
Fourth Affiliated Hospital of China Medical University
2014-2023
China Medical University
2014-2023
Wuhan National Laboratory for Optoelectronics
2020-2022
Guangxi University
2009-2020
Dalian Medical University
2014-2020
First Affiliated Hospital of Dalian Medical University
2014-2020
Third Affiliated Hospital of Harbin Medical University
2013-2019
To confirm the relationship between sex and progression of Coronavirus Disease-19 (COVID-19), its potential mechanism, among severe patients. For this retrospective study, we included 168 consecutive patients with pathogen-confirmed COVID-19 who were hospitalized January 16th February 4th, 2020, at Tongji Hospital in Wuhan, China. Clinical characteristics, laboratory parameters, outcomes compared analyzed males females. In present COVID-19, including 86 82 females, 48 (28.6%) diagnosed as...
To understand how the hyaluronan receptor CD44 regulates tumor metastasis, murine mammary carcinoma TA3/St, which constitutively expresses cell surface CD44, was transfected with cDNAs encoding soluble isoforms of and transfectants (TA3sCD44) were compared parental cells (transfected expression vector only) for growth in vivo vitro. Local release by inhibited ability endogenous to bind internalize mediate TA3 invasion hyaluronan-producing monolayers. Mice intravenously injected TA3/St...
Glioblastoma multiforme (GBM) is the most aggressive brain tumor that, by virtue of its resistance to chemotherapy and radiotherapy, currently incurable. Identification molecules whose targeting may eliminate GBM cells and/or sensitize glioblastoma cytotoxic drugs therefore urgently needed. CD44 a major cell surface hyaluronan receptor cancer stem marker that has been implicated in progression variety types. However, downstream signaling pathways mediate protumor effects role chemoresponse...
Abstract Aim Downregulated in adenoma ( DRA , Slc26a3) is a member of the solute carrier family 26 SLC 26), anion transporters, which mutated familial chloride‐losing diarrhoea (CLD). Besides Cl − ‐rich diarrhoea, CLD patients also have higher‐than‐average incidence intestinal inflammation. In search for potential explanations this clinical finding, we investigated colonic electrolyte transport, mucus layer and susceptibility against dextran sodium sulphate DSS )‐induced colitis Slc26a3 −/−...
Angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) affect angiogenesis differently during embryogenesis tumorigenesis. In an attempt to understand the molecular basis underlying distinct roles of those two homologous molecules, we investigated association Ang-1 Ang-2 with extracellular matrix (ECM). TA3 murine mammary carcinoma (TA3) Lewis lung cells expressing v5 epitope-tagged were used in our studies. The results indicated that is secreted incorporated into ECM tumor cells, whereas not...
The mixing of gastric and pancreatic juice subjects the jejunum to unique ionic conditions with high luminal CO2 tension HCO3 − concentration. We investigated role small intestinal apical anion exchangers PAT-1 (Slc26a6) DRA (Slc26a3) in basal CO2/HCO3 −-stimulated jejunal fluid absorption. Single pass perfusion segments was performed anaesthetised wild type (WT) as well mice deficient DRA, PAT-1, Na+/H+ exchanger 3 (NHE3) or NHE2, carbonic anhydrase II (CAII). Unbuffered saline (pH 7.4) WT...
// Meng Dai 1, * , Jian-Jun Lu 3, Wei Guo 1 Wendan Yu Qimin Wang 4 Ranran Tang Zhipeng Yao Xiao Zhenglin Li Sun Xiuna Qin Wenlin Huang 2, 5 Wu-guo Deng Taihua Wu The First Affiliated Hospital & Institute of Cancer Stem Cell, Dalian Central Hospital, Medical University, Dalian, China 2 Yat-Sen University Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center Medicine, Guangzhou, 3 Department Thoracic Surgery, Yat-sen Second Targeted Drug for Tumors Guangdong...
As a strategy in the development of effective cancer therapeutics, synthetic lethality has been used clinical practice. Poly adenosine diphosphate (ADP)-ribose polymerase inhibitors are first approved drug utilized and achieved promising therapeutic efficacy cells with BRCA1/2 mutation. Nonetheless, most patients wild-type gene not qualified for PARPi therapy. To induce BRCAness phenotype normal status, we identified Pulsatilla Saponin D (SB365), which efficiently inhibited recruitment BRCA1...
Despite significant advances in biology and medicine, the incidence mortality due to breast cancer worldwide is still unacceptably high. Thus, there an urgent need discover new molecular targets. In this article, we show evidence for a novel target human cancer, tetraspan protein epithelial membrane protein-2 (EMP2). Using tissue tumor arrays, expression of EMP2 was measured found be minimal normal mammary tissue, but it upregulated 63% invasive tumors 73% triple-negative tested. To test...
Kallmann syndrome (KS) consists of idiopathic hypogonadotropic hypogonadism (IHH) and anosmia/hyposmia. Currently, the fibroblast growth factor receptor 1 (FGFR1) gene is only known autosomal dominant cause KS, which also associated with synkinesia, midfacial defects, dental agenesis.Mutations in FGFR1 typically demonstrate reduced penetrance, variable expressivity, until recently have been exclusively identified families anosmia. The purpose this study was to determine whether mutations...
MicroRNAs (miRNAs or miRs) are crucial for normal development and maintenance of homeostasis. Dysregulated miRNA expression contributes to numerous pathological conditions, including cancer tumorigenesis. However, a limited number studies have examined the regulatory effects miR-30a-3p in Therefore, present study investigated mechanistic process tumorigenesis liver cancer. The results revealed high DNA methyltransferase 3a (DNMT3a) low HepG2 cells compared with that L02 cell line. A...