A5100331630- Phytochemicals and Antioxidant Activities
- Protein Hydrolysis and Bioactive Peptides
- Lanthanide and Transition Metal Complexes
- Cancer Research and Treatments
- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Nanoparticle-Based Drug Delivery
- Electrochemical sensors and biosensors
- RNA modifications and cancer
- Porphyrin and Phthalocyanine Chemistry
- Natural product bioactivities and synthesis
- Free Radicals and Antioxidants
- Advanced Chemical Sensor Technologies
- Carbon dioxide utilization in catalysis
- RNA Interference and Gene Delivery
- Supercapacitor Materials and Fabrication
- Metal-Organic Frameworks: Synthesis and Applications
- Biochemical effects in animals
- Plant biochemistry and biosynthesis
- Advanced Cellulose Research Studies
- Chemical Synthesis and Reactions
- Nanoplatforms for cancer theranostics
- Electrospun Nanofibers in Biomedical Applications
- Proteins in Food Systems
Ministry of Education of the People's Republic of China
2016-2025
Northwest University
2016-2025
Ludong University
2024-2025
Central South University
2020-2025
Xiamen University of Technology
2025
Chinese Academy of Sciences
2006-2025
Second Xiangya Hospital of Central South University
2024-2025
Fudan University
2014-2025
Dongguan People’s Hospital
2025
Zhongshan Hospital
2025
Since the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, it has rapidly spread across many other countries. While majority patients were considered mild, critically ill involving respiratory failure and multiple organ dysfunction syndrome are not uncommon, which could result death. We hypothesized that cytokine storm is associated with severe outcome. enrolled 102 COVID-19 who admitted to Renmin Hospital (Wuhan, China). All classified into moderate, critical groups...
In this work, a new type of ultrasmall Pt nanoclusters (Pt NCs) was prepared via facile one-pot approach by using yeast extract as the reductant and stabilizer. Besides their excellent water solubility, these extract-stabilized NCs also possess attractive peroxidase mimicking property. They can efficiently catalyze oxidation 3,3,5,5-tetramethylbenzidine (TMB) in coexistence hydrogen peroxide (H2O2). Catalytic mechanism analysis suggested that activity might originate from characteristic...
The conformational stability and activity of Candida antarctica lipase B (CALB) in the polar nonpolar organic solvents were investigated by molecular dynamics quantum mechanics/molecular mechanics simulations. conformation change CALB was examined two aspects: overall active site. simulation results show that is stable solvents. In solvents, site keeps stable, whereas solvent molecules reach into interact intensively with This interaction destroys hydrogen bonding between Ser(105) His(224)....
Inducing cancer differentiation is a promising approach to treat cancer. Here, we identified chlorogenic acid (CA), potential inducer, for therapy, and elucidated the molecular mechanisms underlying its differentiation-inducing effects on cells.Cancer cell was investigated by measuring malignant behavior, including growth rate, invasion/migration, morphological change, maturation, ATP production. Gene expression analyzed microarray analysis, qRT-PCR, protein measurement, biology techniques...
Bruton's tyrosine kinase proteolysis-targeting chimeras (BTK-PROTACs) have emerged as a promising approach to address the limitations of BTK inhibitors. However, conducting rational discovery orally bioavailable BTK-PROTACs presents significant challenges. In this study, dimensionality reduction analysis and model molecule validation were utilized identify some key structural features for improving oral absorption BTK-PROTACs. The results applied optimize newly discovered B1 B2. Compound C13...
As the brain's resident immune cells, microglia perform crucial functions such as phagocytosis, neuronal network maintenance, and injury restoration by adopting various phenotypes. Dynamic imaging of these phenotypes is essential for accessing brain diseases therapeutic responses. Although numerous probes are available pro-inflammatory microglia, no PET tracers have been developed specifically to visualize anti-inflammatory microglia. In this study, we present an 18F-labeled tracer (QTFT)...
Theranostic imaging, where diagnosis is combined with therapy, particularly suitable for a disease that as complex cancer, especially now genomic and proteomic profiling can provide an extensive "fingerprint" of each tumor. With such information, theranostic agents be designed to personalize treatment minimize damage normal tissue. Here we have developed nanoplex platform imaging prostate cancer (PCa). In these proof-of-principle studies, therapeutic containing multimodal reporters was...
The surface and interface could be designed to enhance properties of electrocatalysts, they are regarded as the key characteristics. This report describes modification a bifunctional rht-type metal–organic framework (MOF, Cu-TDPAT) with nanosized electrochemically reduced graphene oxide (n-ERGO). hybrid strategy results in Cu-TDPAT–n-ERGO sensor sensitive selective response toward hydrogen peroxide (H2O2). Compared Cu-TDPAT, exhibits significantly enhanced electrocatalytic activities,...
Borondipyrromethene (Bodipy) dyes with strong solid-state photoluminescence are highly desirable for their applications in OLEDs. In this work, a series of meso-(4-R–C6H4)-substituted Bodipy (R = H B1; R (OCH2CH2)nOCH2CH3, n 0–3 B2–B5, respectively) were prepared through an acid-catalyzed reaction. The flexible ether groups attached to the periphery B2–B5 expected influence molecular arrangement and intermolecular interactions solid state. Crystallographic analysis B1–B4 reveals that...
We report two new near-infrared fluorescent probes based on Rhodol counterpart fluorophore platforms functionalized with dipicolylamine Zn(II)-binding groups. The combinations of the pendant amines and fluorophores provide an effective three-nitrogen-atom one-oxygen-atom binding motif. large Stokes shifts offer sensitive selective florescent responses to Zn(II) ions over other metal ions, allowing a reversible monitoring concentration changes in living cells, detecting intracellular released...
Abstract Confined water has been proven to be of great importance due its pervasiveness and contribution life many fields scientific research. However, the control characterization confined are a challenge. Herein, space is constructed by flexibly changing pH graphene oxide dispersion under self-assembly process hydrogel (GH), adjusted with variation from 10.04 3.52 nm. content in GH increases when pore diameter decreases; corresponding adsorption capacity 243.04 442.91 mg g −1 . Moreover,...
PdPt bimetallic alloy nanowires (Pd/Pt NWs) were found to exhibit excellent oxidase-like activity and can be applied sensitively detect the of acid phosphatase (ACP) in acidic media.