A5103276307- Hepatitis B Virus Studies
- Hepatitis C virus research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Liver Disease Diagnosis and Treatment
- interferon and immune responses
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Long-Term Effects of COVID-19
- SARS-CoV-2 detection and testing
- Clostridium difficile and Clostridium perfringens research
- Influenza Virus Research Studies
- Viral Infections and Immunology Research
- RNA regulation and disease
- RNA Research and Splicing
- Pneumonia and Respiratory Infections
- Cancer-related molecular mechanisms research
- Psoriasis: Treatment and Pathogenesis
- COVID-19 and healthcare impacts
- Respiratory viral infections research
- Inflammatory Biomarkers in Disease Prognosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Bacteriophages and microbial interactions
Wuhan University
2016-2025
Renmin Hospital of Wuhan University
2016-2025
Chinese Academy of Fishery Sciences
2024
Jiaxing University
2023
Central Hospital of Zibo
2023
Northeastern University
2022
Shaoxing People's Hospital
2016
Huazhong Agricultural University
2016
Zhongnan Hospital of Wuhan University
2011-2013
Ningbo No. 2 Hospital
2013
Since the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, it has rapidly spread across many other countries. While majority patients were considered mild, critically ill involving respiratory failure and multiple organ dysfunction syndrome are not uncommon, which could result death. We hypothesized that cytokine storm is associated with severe outcome. enrolled 102 COVID-19 who admitted to Renmin Hospital (Wuhan, China). All classified into moderate, critical groups...
A recently emerging respiratory disease named coronavirus 2019 (COVID-19) has quickly spread across the world. This is initiated by severe acute syndrome coronavirus-2 (SARS-CoV-2) and uncontrolled cytokine storm, but it remains unknown as to whether a robust antibody response related clinical deterioration poor outcome in COVID-19 patients.
An outbreak of severe acute respiratory syndrome novel coronavirus (SARS-CoV-2) epidemic spreads rapidly worldwide. SARS-CoV-2 infection caused mildly to seriously and fatally respiratory, enteric, cardiovascular, neurological diseases. In this study, we detected analyzed the main laboratory indicators related heart injury, creatine kinase isoenzyme-MB (CK-MB), myohemoglobin (MYO), cardiac troponin I (ultra-TnI), N-terminal pro-brain natriuretic peptide (NT-proBNP), in 273 patients with...
Abstract Cytokine storm induced by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a major pathological feature of Disease 2019 (COVID-19) and crucial determinant in COVID-19 prognosis. Understanding the mechanism underlying SARS-CoV-2-induced cytokine critical for control. Here, we identify that SARS-CoV-2 ORF3a host hypoxia-inducible factor-1α (HIF-1α) play key roles virus infection pro-inflammatory responses. RNA sequencing shows HIF-1α signaling, immune response,...
Summary Background A recently emerging respiratory disease named coronavirus 2019 (COVID-19) has quickly spread across the world. This is initiated by severe acute syndrome coronavirus-2 (SARS-CoV-2) and uncontrolled cytokine storm, but it remains unknown as to whether a robust antibody response related clinical deterioration poor outcome in laboratory-confirmed COVID-19 patients. Methods Anti-SARS-CoV-2 IgG IgM antibodies were determined chemiluminescence analysis (CLIA) patients from...
The Systemic Immune-Inflammation Index (SII) is a quantitative measurement of the systemic immune-inflammatory response in human body. SII has been shown to have prognostic value various clinical settings, including critical illness, sepsis, and cancer. Its role chronic obstructive pulmonary disease (COPD) remains unclear requires further investigation.We analyzed demographic data from 16,636 participants National Health Nutrition Examination Survey. Logistic regression analysis was...
In December 2019, the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) broke out in Wuhan. Epidemiological and clinical characteristics of patients with COVID-19 have been reported, but relationships between laboratory features viral load has not comprehensively described.Adult inpatients (≥18 years old) who underwent multiple (≥5 times) nucleic acid tests nasal pharyngeal swabs were recruited from Renmin Hospital Wuhan University, including...
Abstract Background Among patients with coronavirus disease 2019 (COVID-19), the cases of a significant proportion are severe. A viral nucleic acid test is used for diagnosis COVID-19, and some hematological indicators have been in auxiliary identification severity COVID-19. Regarding body fluid samples, except being testing, relationship between COVID-19 routine parameters not known. Our aim was to investigate value urine biochemical prediction Methods total 119 were enrolled at Renmin...
Abstract Hepatocellular carcinoma (HCC) is a highly lethal malignant tumor, and the current non‐invasive diagnosis method based on serum markers, such as α‐fetoprotein (AFP), des‐γ‐carboxy‐prothrombin (DCP), has limited efficacy in detecting it. Therefore, there critical need to develop novel biomarkers for HCC. Recent studies have highlighted potential of exosomes biomarkers. To enhance exosome enrichment, silicon dioxide (SiO 2 ) microsphere‐coated three‐dimensional (3D) hierarchical...
Recent observational studies revealed an association between gut microbiota and aging, but whether are causally associated with the aging process remains unknown. We used a two-sample Mendelian randomization approach to investigate causal biological age acceleration using largest available GWAS summary data from MiBioGen consortium on acceleration. further conducted sensitivity analysis MR-PRESSO, MR-Egger regression, Cochran Q test, reverse MR analysis. Streptococcus (IVW, β = 0.16, p...
During influenza A virus (IAV) infection, cytokine storms play a vital and critical role in clinical outcomes. We have previously reported that microRNA (miR)-302c regulates IAV-induced IFN expression by targeting the 3'-UTR of nuclear factor κB (NF-κB)-inducing kinase. In current study, we found miR-302a, another member miR-302 cluster, controls storm. According to results from cell-based knockout mouse models, IAV induces storm via interferon regulatory factor-5 (IRF-5). also infection...
Hepatitis B virus (HBV) infection may cause acute hepatitis B, chronic (CHB), liver cirrhosis, and hepatocellular carcinoma (HCC). However, the mechanisms by which HBV evades host immunity maintains are largely unknown. Here, we revealed that matrix metalloproteinase 9 (MMP-9) is activated in peripheral blood mononuclear cells (PBMCs) of HBV-infected patients, stimulates MMP-9 expression macrophages PBMCs isolated from healthy individuals. plays important roles breakdown extracellular...
Abstract Background & Aims The outbreak of coronavirus disease 2019 (COVID‐19) has been declared a pandemic. Although COVID‐19 is caused by infection in the respiratory tract, extrapulmonary manifestations including dysregulation immune system and hepatic injury have observed. Given high prevalence hepatitis B virus (HBV) China, we sought to study impact severe acute syndrome 2 (SARS‐CoV‐2) HBV coinfection patients. Methods Blood samples 50 SARS‐CoV‐2 coinfected patients, 56...
The galectin 3 binding protein (LGALS3BP, also known as 90K) is a ubiquitous multifunctional secreted glycoprotein originally identified in cancer progression. It remains unclear how 90K functions innate immunity during viral infections. In this study, we found that infections resulted elevated levels of 90K. Further studies demonstrated expression suppressed virus replication by inducing IFN and pro-inflammatory cytokine production. Upon investigating the mechanisms behind event,...
Coronavirus disease 2019 (COVID-19) has caused a global pandemic associated with substantial morbidity and mortality. Nasopharyngeal swabs sputum samples are generally collected for serial viral load screening of respiratory contagions, but temporal profiles these not completely clear in patients COVID-19. We performed an observational cohort study at Renmin Hospital Wuhan University, which involved 31 confirmed COVID-19 or without underlying diseases. obtained from each patient, was...
Chronic inflammation induced by hepatitis B virus (HBV) is a major causative factor associated with the development of cirrhosis and hepatocellular carcinoma. In this study, we investigated roles three inflammatory factors, IL-8, IL-29 (or IFN-λ1), cyclooxygenase-2 (COX-2), in HBV infection. We showed that expression IL-29, COX-2 genes was enhanced HBV-infected patients or HBV-expressing cells. HBV-transfected human lymphocytes hepatocytes, activates production which turn enhances COX-2....
Hepatitis C virus (HCV) infection is a leading cause of chronic liver diseases and hepatocellular carcinoma (HCC) Golgi protein 73 (GP73) serum biomarker for HCC. However, the mechanism underlying GP73 regulates HCV largely unknown. Here, we revealed that acts as novel negative regulator host innate immunity to facilitate infection. expression activated correlated with interferon-beta (IFN-β) production during in patients' serum, primary human hepatocytes (PHHs) hepatoma cells through...
Asymptomatic transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a potential problem for pandemic control through public health strategies. Our results demonstrate that asymptomatic COVID-19 patients have better outcomes than symptomatic patients. This may been due to more active cellular immune responses and normal liver function. Since no clinical symptoms which can easily prevent timely diagnosis treatment, they cause greater risk virus patients, poses major...