A5100450006- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- HIV Research and Treatment
- Proteins in Food Systems
- SARS-CoV-2 and COVID-19 Research
- Cytokine Signaling Pathways and Interactions
- Food Allergy and Anaphylaxis Research
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Cytomegalovirus and herpesvirus research
- PI3K/AKT/mTOR signaling in cancer
- Viral-associated cancers and disorders
- interferon and immune responses
- RNA Research and Splicing
- Hepatitis B Virus Studies
- Animal Virus Infections Studies
- CAR-T cell therapy research
- Cancer-related gene regulation
- Microbial Fuel Cells and Bioremediation
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Influenza Virus Research Studies
- Protein Hydrolysis and Bioactive Peptides
Sichuan University
2022-2024
West China Hospital of Sichuan University
2022-2024
Shanghai Veterinary Research Institute
2024
Hubei Academy of Agricultural Sciences
2023-2024
Ministry of Agriculture and Rural Affairs
2023-2024
Hainan Provincial Hospital of Traditional Chinese Medicine
2024
Chinese Academy of Agricultural Sciences
2024
Chongqing University
2020-2023
Wuhan University
2016-2023
National Institute of Allergy and Infectious Diseases
2023
An outbreak of severe acute respiratory syndrome novel coronavirus (SARS-CoV-2) epidemic spreads rapidly worldwide. SARS-CoV-2 infection caused mildly to seriously and fatally respiratory, enteric, cardiovascular, neurological diseases. In this study, we detected analyzed the main laboratory indicators related heart injury, creatine kinase isoenzyme-MB (CK-MB), myohemoglobin (MYO), cardiac troponin I (ultra-TnI), N-terminal pro-brain natriuretic peptide (NT-proBNP), in 273 patients with...
ABSTRACT How viruses evolve to select their receptor proteins for host cell entry is puzzling. We recently determined the crystal structures of NL63 coronavirus (NL63-CoV) and SARS (SARS-CoV) receptor-binding domains (RBDs), each complexed with common receptor, human angiotensin-converting enzyme 2 (hACE2), proposed existence a virus-binding hot spot on hACE2. Here we investigated function this hypothetical using structure-guided biochemical functional assays. The consists salt bridge...
Hepatitis B virus (HBV) is a major risk factor for the development and progression of hepatocellular carcinoma. It has been reported that viral infection can interfere with cellular microRNA (miRNA) expression participate in pathogenesis oncogenicity. Here, we report decreasing levels miRNA miR-192-3p associated rising HBV DNA serum patients. We revealed repressed through hepatitis x protein interaction c-myc. further showed was by transfection vitro mouse model, leading to autophagy. Using...
Hepatitis B viral infection is one of the leading causes hepatocellular carcinoma (HCC) worldwide. Although several factors have been identified that may increase risk for HCC development, molecular mechanisms to transformation normal hepatocytes into cancer cells remain elusive. In this study, we demonstrated intracellular hepatitis e antigen (HBeAg) and its precore precursors, but not their homologous core protein, could associate with NUMB thereby impair stability transcriptional activity...
Hepatitis B virus (HBV) is a major risk factor for the development and progression of hepatocellular carcinoma (HCC). It has been reported that viral infection can interfere with expression cellular microRNA (miRNA) to affect oncogenesis. In this study, we showed miR-520c-3p was upregulated in liver tumor specimens, revealed HBV enhanced through interaction protein X (HBx) transcription CREB1. We further induced by transfection/infection caused epithelial-mesenchymal transition (EMT). Using...
The M1 family of metalloproteases represents a large number exopeptidases that cleave single amino acid residues from the N-terminus peptide substrates. One member this has been well studied is aminopeptidase N (APN), multifunctional protease known to biologically active peptides and aide in coronavirus entry. proteolytic activity APN promotes cancer angiogenesis metastasis making it an important target for therapy. To understand substrate specificity development targeted inhibitors, we used...
Tumor cell surface aminopeptidase N (APN or CD13) has two puzzling functions unrelated to its enzymatic activity: mediating tumor motility and serving as a receptor for tumor-homing peptides (peptides that bring anti-cancer drugs cells). To investigate APN-based therapy, we determined the crystal structure of APN complexed with peptide containing representative Asn-Gly-Arg (NGR) motif. The binds active site, but it resists degradation due distorted scissile bond. explore motility, examined...
Abstract Background Psoriasis is a persistent inflammatory dermatological disorder. Tanshinone IIA (tan‐IIA) biologically active compound in the self‐made Xiao‐Yin decoction (SMXYD) and exhibits diverse biological properties, such as anti‐proliferative anti‐inflammatory effects. The objective of this investigation was to assess potential tan‐IIA therapeutic agent against psoriasis. Methods Network pharmacology employed ascertain constituents pathways associated with SMXYD We conducted CCK‐8,...
Abstract Background The human myxovirus resistance 2 (Mx2/MxB) protein was originally found to regulate cytoplasmic-nuclear transport but recently reported restrict HIV-1 replication by binding capsid (CA), preventing uncoating, the nuclear import of pre-integration complex (PIC) and viral DNA integration. This work explores mechanisms MxB-mediated inhibition. Results We demonstrated that MxB represses NUP358-mediated PIC replication. Moreover, MxB’s effects on depend critically cofactor...
HIV is the causative pathogen of AIDS, which has generated worldwide concern. Long noncoding RNAs (lncRNAs) are a rising star in virus-host cross-talk pathways; they differentially expressed during many viral infections and involved multiple biological processes. Currently, lncRNA growth arrest-specific transcript 5 (GAS5) known to be downregulated HIV-1 infection. However, functions mechanisms GAS5 infection remain largely unknown. In this report, it was found for first time that could...
Increasing evidence shows microRNAs (miRNAs) are engaged in hepatocelluar carcinoma (HCC). To identify novel feasible miRNA/mRNA pairs involved hepatocarcinogenesis, an in-depth analysis of miRNomes human non-tumor liver and HCC samples was carried out this study. Firstly, differentially expressed miRNAs were obtained from deep sequencing 15 samples, verified independent data The Cancer Genome Atlas (TCGA) database. Then, mRNA targets selected TCGA, the differential with negative...
Innate immunity is the first-line defense against antiviral or antimicrobial infection. RIG-I and MDA5, which mediate recognition of pathogen-derived nucleic acids, are essential for production type I interferons (IFN). Here we identified mitochondrion depolarization inducer carbonyl cyanide 3-chlorophenylhydrazone (CCCP) inhibited response activity IFN during viral Furthermore, found that PTEN-induced putative kinase 1 (PINK1) E3 ubiquitin-protein ligase Parkin mediated mitophagy, thus...