A5023835147- COVID-19 Clinical Research Studies
- HIV Research and Treatment
- Viral Infections and Vectors
- Hepatitis C virus research
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Viral Infections and Outbreaks Research
- Tuberculosis Research and Epidemiology
- Hepatitis B Virus Studies
- Cytomegalovirus and herpesvirus research
- Immunodeficiency and Autoimmune Disorders
- COVID-19 and healthcare impacts
- Mosquito-borne diseases and control
- Mycobacterium research and diagnosis
- HIV, Drug Use, Sexual Risk
- Liver Disease Diagnosis and Treatment
- Vitamin C and Antioxidants Research
- Diagnosis and treatment of tuberculosis
- Bacillus and Francisella bacterial research
- Rabies epidemiology and control
- COVID-19 Impact on Reproduction
- Renal function and acid-base balance
- Pneumocystis jirovecii pneumonia detection and treatment
- Potassium and Related Disorders
Zhongnan Hospital of Wuhan University
2012-2025
Wuhan University
2012-2025
Since December 2019, coronavirus disease 2019 (COVID-19), caused by severe adult respiratory syndrome 2, occurred in Wuhan, and rapidly spread throughout China. This study aimed to clarify the characteristics of patients with refractory COVID-19.In this retrospective single-center study, we included 155 consecutive confirmed COVID-19 Zhongnan Hospital Wuhan University from 1 January 5 February. The cases were divided into general groups according clinical efficacy treatment after...
Abstract Background In December 2019, the coronavirus disease 2019 (COVID-19) emerged in Wuhan city and spread rapidly throughout China world. this study, we aimed to describe clinical course outcomes of older patients with COVID-19. Methods This is a retrospective investigation hospitalized confirmed COVID-19 at Zhongnan Hospital University from January 1, 2020, February 10, 2020. Results total, 203 were diagnosed COVID-19, median age 54 years (interquartile range, 41–68; 20–91 years). Men...
Summary Background Viral clearance is one important indicator for the recovery of SARS-CoV-2 infected patients. Previous studies have pointed out that suboptimal T and B cell responses can delay viral in MERS-CoV SARS-CoV The role leukomonocytes COVID-19 patients not yet well defined. Methods From January 26 to February 28, 2020, an observational study was launched at Department Infectious Diseases, Zhongnan Hospital Wuhan University, Wuhan, China. We enrolled 25 laboratory-confirmed...
ABSTRACT. People living with HIV (PLWH) are known to exhibit more severe or prolonged symptoms of mpox (formerly monkeypox). However, the impact acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on PLWH has not been adequately described. We report a case in an AIDS patient who had recurrent due SARS-CoV-2 infection. The presented low CD4 + lymphocyte count (CD4 count) without antiretroviral therapy (ART) and suffered from mpox. ART was initiated 17 days after diagnosis mpox, patient’s...
<title>Abstract</title> Pneumonia is common in patients with severe fever thrombocytopenia syndrome (SFTS), and respiratory failure one of its most complications. The aim this study was to establish a nomogram for predicting development SFTS pneumonia. Data demographics, comorbidities, clinical manifestations, laboratory parameters, complications, outcomes pneumonia were collected. Independent predictors on multivariate logistic regression used construct the predictive model. Of 167 we...
Until recently, severe fever with thrombocytopenia syndrome (SFTS)-related disseminated intravascular coagulation (DIC) had not been elucidated. This study aimed to explore the clinical characteristics and outcomes of DIC in patients SFTS. Patients diagnosed SFTS who were admitted Zhongnan Hospital Wuhan University from August 2016 October 2023 included. Patients' demographics data collected. According presence DIC, they assigned into non-DIC groups. Independent risk factors for prognosis...
Abstract Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging zoonosis a high fatality rate in China. Previous studies have reported that dysregulated inflammatory response associated disease pathogenesis and mortality patients SFTS. This investigation aimed to evaluate the prevalence characteristics of systemic (SIRS), its impact on prognosis. Methods Data demographic characteristics, comorbid conditions, clinical manifestations, laboratory parameters, survival time...
CSF PCR is the standard diagnostic technique used in resource-rich settings to detect pathogens of CNS infection. However, it not currently for routine testing China. Knowledge opportunistic infections among people living with HIV China limited.Intensive cerebrospiral fluid (CSF) was performed evaluate bacterial, viral and fungal etiologies. Pathogen-specific primers were DNA from cytomegalovirus (CMV), herpes simplex virus (HSV), varicella-zoster (VZV), Epstein-Barr (EBV), human herpesvirus...
Tuberculosis (TB) is an important opportunistic infection in acquired immunodeficiency diseases (AIDS). Although the frequency of CD4+CD8+ double-positive (DP) T cells has been observed to increase pathological conditions, their role (phenotypic and functional) poorly described, especially human virus (HIV) with TB (HIV/TB (HT) coinfection).The percentage phenotypic functional properties peripheral blood DP patients HT coinfection comparison uninfected controls HIV or mono-infection were...
The increased pancreatic enzymes have recently been reported in patients with severe fever thrombocytopenia syndrome (SFTS). However, its significance has not elucidated clearly. aim of this study was to explore the prevalence, clinical characteristics elevated (amylase and lipase) association AP SFTS.Data demographics, comorbid conditions, symptoms, laboratory parameters survival time SFTS were collected. Patients assigned into non-AP groups according diagnostic criteria AP. group divided...
Abstract The epidemic of coronavirus disease 2019 (COVID-19) began in China and had spread rapidly to many other countries. This study aimed identify risk factors associated with delayed negative conversion SARS-CoV-2 COVID-19 patients. In this retrospective single-centre study, we included 169 consecutive patients confirmed Zhongnan Hospital Wuhan University from 15th January 2nd March. cases were divided into two groups according the median time conversion. differences between compared....
MicroRNAs (miRNAs) are widely involved in immune regulation during virus infection. Several studies showed that the expression of miR-146a was increased human immunodeficiency type I (HIV-1)-infected cells, but definitive function HIV-1 infection remains obscure. The production chemokine (C-C motif) ligand 5 (CCL5) macrophages has been reported to play an important role HIV/AIDS-associated pathogenesis. In this study, we examined effects on CCL5 HIV-1-infected macrophages. Gain and loss...
Summary Background Coronavirus disease 2019 (COVID-19) is an emerging infectious disease.It was first reported in Wuhan, China, and then broke out on a large scale around the world.This study aimed to assess clinical significance of two different nutritional indices 245 patients with COVID-19. Methods In this retrospective single-center study, we finally included consecutive who confirmed COVID-19 Wuhan University Zhongnan Hospital from January 1 February 29. Cases were classified as either...
Abstract Functional exhaustion of immune cells is a defining characteristic HIV-1 chronic infections, exhibiting dysregulation cellular responses and expression co-inhibitory receptors. Although the molecular mechanisms controlling immune-cell retains largely unknown, checkpoint blockade strategy has shown inspiring potential to reinvigorate T cell functions in infections. In this study, we investigated peripheral blood mononuclear (PBMCs) markers from 109 HIV-1-infected patients found they...
Background Currently the responses of peripheral cytokine-secreting cells in natural course human immunodeficiency virus (HIV) and tuberculosis (TB) co-infection haven’t been fully elucidated. Methods The function proinflammatory, regulatory cytotoxic were investigated by direct intracellular cytokine staining (ICS) flow cytometry, additionally, absolute numbers different measured among patients with HIV/TB (HT group), compared them healthy controls (HC TB (TB group) HIV infection (HIV...
Background The burden of hepatitis B virus (HBV), C (HCV), and syphilis coinfections remains disproportionately high among people living with HIV/AIDS. Hubei province is located in central China, where there are distinct regional characteristics the distribution HIV/AIDS acquired via diverse transmission routes AIDS epidemic itself. Objective We aimed to estimate magnitude HBV, HCV, or blood-borne transmission, which includes former paid blood donors, contaminated recipients, intravenous...
Background Liver injury in coronavirus disease 2019 (COVID-19) patients was poorly understood. Methods The markers of liver injury, severity and prognosis among 495 COVID-19 Zhongnan Hospital Wuhan University from 1st January to 11th March were retrospectively analyzed. Results levels aspartate aminotransferase (AST) (50.1 ± 38.4 vs. 31.4 39.1, P < 0.001), gamma-glutamyl transpeptidase (GGT) (70.3 70.2 34.1 34.7, 0.001) fibrinogen-to-albumin-ratio (FAR) (13.4 4.0 10.4 3.4, greater than...
Electrolytes play a vital role in myocardial electrophysiological activities the human body. Electrolyte disturbances can affect depolarisation and repolarisation of cells thus result arrhythmia. The most common electrolyte disturbance among hospitalised patients is hyponatraemia. We report on case an acquired immune deficiency syndrome patient with decompensated cirrhosis, who developed sinus arrest from electrocardiogram manifestations at different sodium concentrations were also recorded...
HBV coinfection is frequent in people living with HIV (PLWH) and the leading cause of hepatocellular carcinoma (HCC). While risk prediction methods for HCC patients monoinfection have been proposed, suitable biomarkers early diagnosis PLWH remain uncommon. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to examine serum protein alterations non-HCC co-infection. Gene Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG), Disease (DO) enrichment analysis were performed on...
Increased frequency of circulating double negative T (DNT, CD4-CD8-CD3+) cells with protective immune function has been observed in human immunodeficiency virus (HIV) infection and tuberculosis (TB). Here the role TCRαβ+ DNT was further investigated HIV/TB co-infection.A cross-sectional study conducted to investigate functional profiles peripheral including apoptosis, chemokine cytokine expression among healthy individuals patients TB, HIV co-infection by cell surface staining intracellular...
<title>Abstract</title> Background Until recently, severe fever with thrombocytopenia syndrome (SFTS)-related disseminated intravascular coagulation (DIC) had not been elucidated. This study aimed to explore the clinical characteristics and outcomes of DIC in patients SFTS. Methods Patients diagnosed SFTS who were admitted Zhongnan Hospital Wuhan University from August 2016 October 2023 included. Patients’ demographics data collected. According presence DIC, they assigned into non-DIC...
ABSTRACT Severe fever with thrombocytopenia syndrome (SFTS) is an emerging zoonosis caused by a novel bunyavirus. Until recently, rhabdomyolysis in SFTS was not elucidated. The objective of this study to investigate the prevalence and clinical characteristics its association AKI prognosis patients SFTS. A total 231 consecutive diagnosed were enrolled, including 144 (62.3%) no group 87 (37.7%) group. Clinical laboratory parameters compared between groups. Patients had more frequency...