A5100462223- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Hepatitis B Virus Studies
- Viral-associated cancers and disorders
- Viral Infections and Vectors
- Lymphoma Diagnosis and Treatment
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- SARS-CoV-2 detection and testing
- CNS Lymphoma Diagnosis and Treatment
- Influenza Virus Research Studies
- Cancer-related molecular mechanisms research
- Muscle and Compartmental Disorders
- Viral Infections and Outbreaks Research
- Cancer Immunotherapy and Biomarkers
- Precipitation Measurement and Analysis
- HIV Research and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- RNA modifications and cancer
- COVID-19 and healthcare impacts
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- COVID-19 epidemiological studies
Huazhong University of Science and Technology
2020-2025
Tongji Hospital
2020-2025
Zhongnan Hospital of Wuhan University
2016-2025
Wuhan University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
National Health and Family Planning Commission
2025
Ministry of Education of the People's Republic of China
2021
Xiangya Hospital Central South University
2020
Central South University
2020
Since December 2019, coronavirus disease 2019 (COVID-19), caused by severe adult respiratory syndrome 2, occurred in Wuhan, and rapidly spread throughout China. This study aimed to clarify the characteristics of patients with refractory COVID-19.In this retrospective single-center study, we included 155 consecutive confirmed COVID-19 Zhongnan Hospital Wuhan University from 1 January 5 February. The cases were divided into general groups according clinical efficacy treatment after...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel that causes disease 2019 (COVID-19) in human beings, has caused serious public health issue.1 Attention to pancreatic injury is lacking, which may impact patients' prognosis. In this study, we explored the expression and distribution of angiotensin-converting enzyme (ACE2), receptor SARS-CoV-2, pancreas. Combined with clinical data, showed can occur some COVID-19 patients.
Abstract Background In December 2019, the coronavirus disease 2019 (COVID-19) emerged in Wuhan city and spread rapidly throughout China world. this study, we aimed to describe clinical course outcomes of older patients with COVID-19. Methods This is a retrospective investigation hospitalized confirmed COVID-19 at Zhongnan Hospital University from January 1, 2020, February 10, 2020. Results total, 203 were diagnosed COVID-19, median age 54 years (interquartile range, 41–68; 20–91 years). Men...
Abstract Objectives Comorbidities have significant indications for the disease outcome of COVID-19, however which underlying diseases that contribute most to aggravate conditions COVID-19 patients is still largely unknown. SARS-CoV-2 viral clearance a golden standard defining recovery infections. To dissect could impact on clearance, we enrolled 106 who were hospitalized in Zhongnan Hospital Wuhan University, Wuhan, China between Jan 5 and Feb 25, 2020. Methodology We comprehensively...
Abstract The ongoing outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) started in the end China has triggered a global public health crisis. Previous studies have shown that SARS-CoV-2 infects cells binding angiotensin-converting enzyme (ACE2), which is same as SARS-CoV. expression and distribution ACE2 pancreas are unknown. At time, injury after infection not been concerned. Here, we collected datasets (bulk RNA-seq single-cell...
Coronavirus disease 2019 (COVID-19) is a global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).SARS-CoV-2 infection was first detected in Wuhan, China late December 2019.The virus spreading rapidly to other cities of and accumulating cases had been reported (Li et al. 2020).On March 11, 2020, WHO declared the outbreak SARS-CoV-2 as pandemic.As June 28, around 10 million COVID-19 have 216 countries or territories worldwide death toll has passed 490,000...
Summary Background Viral clearance is one important indicator for the recovery of SARS-CoV-2 infected patients. Previous studies have pointed out that suboptimal T and B cell responses can delay viral in MERS-CoV SARS-CoV The role leukomonocytes COVID-19 patients not yet well defined. Methods From January 26 to February 28, 2020, an observational study was launched at Department Infectious Diseases, Zhongnan Hospital Wuhan University, Wuhan, China. We enrolled 25 laboratory-confirmed...
BACKGROUND:The aim of this study was to determine the effect C-reactive protein (CRP), lymphocytes (LYM), and ratio CRP LYM (CRP/LYM) on assessing prognosis COVID-19 severity at early stages disease. MATERIAL AND METHODS:A total 108 hospitalized patients diagnosed with in Zhongnan Hospital Wuhan University from January 17, 2020 March 12, were enrolled. Data demographic parameters, clinical characteristics, laboratory indicators, manifestation, outcome disease collected. The divided into a...
Respiratory viral diseases have posed a persistent threat to public health due their high transmissibility. Influenza virus and SARS-Cov-2 are both respiratory viruses that caused global pandemics. A zero-COVID-19 strategy is policy imposed stop community transmission of COVID-19 as soon it detected. In this study, we aim examine the epidemiological characteristics seasonal influenza in past five years before after emergence China observe possible impact on influenza.Data from two data...
<title>Abstract</title> Pneumonia is common in patients with severe fever thrombocytopenia syndrome (SFTS), and respiratory failure one of its most complications. The aim this study was to establish a nomogram for predicting development SFTS pneumonia. Data demographics, comorbidities, clinical manifestations, laboratory parameters, complications, outcomes pneumonia were collected. Independent predictors on multivariate logistic regression used construct the predictive model. Of 167 we...
Until recently, severe fever with thrombocytopenia syndrome (SFTS)-related disseminated intravascular coagulation (DIC) had not been elucidated. This study aimed to explore the clinical characteristics and outcomes of DIC in patients SFTS. Patients diagnosed SFTS who were admitted Zhongnan Hospital Wuhan University from August 2016 October 2023 included. Patients' demographics data collected. According presence DIC, they assigned into non-DIC groups. Independent risk factors for prognosis...
Colorectal cancer (CRC) frequently metastasizes to the liver, worsening patient outcomes. The formation of a pre-metastatic niche (PMN) is essential for this process, but how primary colon tumor orchestrates PMN remains unclear. This study investigated role CRC-derived exosomes using CT-26 murine carcinoma cells. effects these on immune cells, specifically M1 macrophage polarization and CD8 + T cell viability, were assessed. HSP90B1 expression in CT-26-derived was analyzed understand its...
Abstract Background & Aims The coronavirus disease 2019 (COIVD-19) caused by SARS-CoV-2 has been characterized as a pandemic, which causes serious public health challenge in the world. A very large group of patients infected HBV reported worldwide, especially China. In order to answer whether specific treatment strategy on coinfected with and SARS-CoV-2, it requires profound understanding clinical characteristics those patients. However, impacts infection remain largely unknown. Approach...
Previous studies have shown that the high mortality caused by viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus primarily results from complications of a cytokine storm. Therefore, it is critical to identify key factors participating in Here we demonstrate interferon-induced protein 35 (IFP35) plays an important role storm induced SARS-CoV-2 infection. We find levels serum IFP35 individuals with correlates severity syndrome. Using mouse model...
Abstract Long noncoding RNAs (lncRNAs) play important roles in regulating HIV-1 infection and virus-host interactions. However, it is unclear whether how ART alters lncRNAs HIV-infected patients. In the present study, we investigated changes of PBMCs from patients pre- post-ART. We identified a total 974 whose expression was restored to normal levels after ART. Cis-acting analysis showed that six have cis-regulated target genes, among which RP11-290F5.1 interferon regulatory factor 2 (IRF2)...
Abstract The epidemic of coronavirus disease 2019 (COVID-19) began in China and had spread rapidly to many other countries. This study aimed identify risk factors associated with delayed negative conversion SARS-CoV-2 COVID-19 patients. In this retrospective single-centre study, we included 169 consecutive patients confirmed Zhongnan Hospital Wuhan University from 15th January 2nd March. cases were divided into two groups according the median time conversion. differences between compared....
Abstract Comorbidities are important for the disease outcome of COVID‐19, however, which underlying diseases that contribute most to aggravate conditions COVID‐19 patients still unclear. Viral clearance is laboratory test defining recovery infections. To better understand risk factors delaying viral clearance, we retrospectively analyzed 161 clinical cases in Zhongnan Hospital Wuhan University, Wuhan, China between January 5 and March 13, 2020. The demographic, data, as well patient...
Purpose-Immunotherapy has revolutionized cancer therapy, becoming the standard of care for various malignancy treatments. Human immunodeficiency virus (HIV) patients, however, are an underserved group with limited access to clinical trials and therapy. This study was evaluate safety efficacy programmed cell death 1 (PD - 1) inhibitors in patients advanced HIV/acquired syndrome (AIDS). Methods Materials-We performed a prospective, open-label, nonrandomized, phase single center study. Patients...
Coronavirus Disease 2019 (COVID-19) emerges as a global pandemic and there is lack of evidence about the clinical course outcome patients on maintenance hemodialysis (MHD).Here we conducted retrospective longitudinal study aimed to analyze features MHD hospitalized with COVID-19.Of 3126 inpatients COVID-19 at 3 Branches Wuhan Tongji Hospital from Jan 18th Mar 9th, 2020, 19 were undergoing hemodialysis.Among COVID-19, 6 (31.6%) died, 13 (68.4%) able be discharged.Baseline characteristics,...
Abstract Background AIDS-related KS generally involves cutaneous lesions, that slowly progress over months to years. Neither rapidly progressing of nor complicated with hemophagocytic syndrome (HPS) has rarely been reported. Case presentation We report a rare case rapid progression Kaposi’s sarcoma in severely immunosuppressed patient HIV-infection. The symptoms this were atypical, showing only persistent high fever and progressed syndrome. This was successfully treated antiretroviral...
Abstract To evaluate clinical value of metagenomic next-generation sequencing (mNGS) in people living with HIV/AIDS (PLWHA) who had CNS disorders. Cerebrospinal fluid (CSF) samples from 48 PLWHA presenting disorders were sequenced using mNGS and compared conventional diagnostic methods. In total, 36/48 ss(75%) patients diagnosed pathogen(s) infection by mNGS, the positive detection proportion was higher than that methods (75% vs 52.1%, X 2 = 5.441, P 0.020). Thirteen out (27.1%) detected 3–7...
<title>Abstract</title> Combination antiretroviral therapy (cART) has improved outcomes for human immunodeficiency virus (HIV) associated non-Hodgkin lymphoma. This is an analysis of 127 patients with HIV Burkitt lymphoma (HIV-BL) and diffuse large B-cell (HIV-DLBCL) treated in China over a 17-year period during the cART rituximab era. The median CD4 count cohorts was 0.141×10<sup>9</sup>/L (range, 0.001–0.861×10<sup>9</sup>/L). DA-EPOCH ± R (54%) were most commonly used HIV-BL. CHOP (42%)...
ABSTRACT Severe fever with thrombocytopenia syndrome (SFTS) is an emerging zoonosis caused by a novel bunyavirus. Until recently, rhabdomyolysis in SFTS was not elucidated. The objective of this study to investigate the prevalence and clinical characteristics its association AKI prognosis patients SFTS. A total 231 consecutive diagnosed were enrolled, including 144 (62.3%) no group 87 (37.7%) group. Clinical laboratory parameters compared between groups. Patients had more frequency...
Combination antiretroviral therapy (ART) has improved outcomes for human immunodeficiency virus (HIV) associated non-Hodgkin lymphoma. This is an analysis of 127 patients with HIV Burkitt lymphoma (HIV-BL) and diffuse large B-cell (HIV-DLBCL) treated at the Zhongnan Hospital Wuhan University over a 17-year period during ART rituximab era. The median CD4 count cohorts was 0.141 × 109/L (range, 0.001-0.861 109/L). DA-EPOCH ± R (54%) were most commonly used in HIV-BL. CHOP± (42%) to treat...