A5084621356- Viral Infections and Vectors
- Fire effects on ecosystems
- Viral Infections and Outbreaks Research
- interferon and immune responses
- HIV Research and Treatment
- MicroRNA in disease regulation
- Herpesvirus Infections and Treatments
- Extracellular vesicles in disease
- Influenza Virus Research Studies
- Vector-Borne Animal Diseases
- Mosquito-borne diseases and control
- RNA modifications and cancer
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- Viral Infections and Immunology Research
- Toxin Mechanisms and Immunotoxins
- RNA Research and Splicing
- Immune cells in cancer
- Tea Polyphenols and Effects
- Cancer, Hypoxia, and Metabolism
- Psoriasis: Treatment and Pathogenesis
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- Long-Term Effects of COVID-19
Wuhan Institute of Virology
2016-2025
Wuhan University
2016-2025
Zunyi Medical University
2025
China National Offshore Oil Corporation (China)
2024
State Key Laboratory of Virology
2012-2023
Huazhong University of Science and Technology
2016-2023
Zhongnan Hospital of Wuhan University
2022-2023
Institute of Vegetables and Flowers
2022
Chinese Academy of Agricultural Sciences
2022
Ministry of Agriculture and Rural Affairs
2022
Abstract Hantaan virus (HTNV) infection causes severe hemorrhagic fever with renal syndrome (HFRS) in humans and the infectious process can be regulated by autophagy. The phosphatase tensin homolog (PTEN) protein has antiviral effects plays a critical role autophagy pathway. However, relationship between PTEN HTNV is not clear whether PTEN‐regulated involves replication unknown. Here, we identified that inhibits expression vitro vivo. glycoprotein Gc promotes ubiquitination degradation...
Metastatic dissemination of primary tumors is responsible for 90% colorectal cancer (CRC) deaths. The presence positive lymph nodes, which separates stage I/II from III CRC, a particularly key factor in patient management. Here, we describe results quantitative proteomic survey to identify molecular correlates node status. Laser capture microdissection and two-dimensional difference gel electrophoresis were used establish expression profiles 980 discrete protein features 24 human CRC...
Abstract NONO, SFPQ and PSPC1 make up a family of proteins with diverse roles in transcription, RNA processing DNA double-strand break (DSB) repair. To understand long-term effects loss we characterized murine embryonic fibroblasts (MEFs) from knockout mice. In the absence genotoxic stress, wild-type mutant MEFs showed similar growth rates cell cycle distributions, mutants were only mildly radiosensitive. Further investigation that NONO deficiency led to upregulation PSPC1, which replaced...
Cytokines secreted in the tumor microenvironment function cancer cachexia (CC), a common clinicopathological syndrome associated with adipocyte wasting and skeletal muscle atrophy. Extracellular vesicles (EVs) by cells actively engage inter-tissue communication; EVs enclosed cytokines are largely undefined CC adipocytes wasting.EVs derived from Lewis lung carcinoma (LLC) colorectal C26 were extracted characterized. Conditioned medium applied to 3 T3-L1 adipocytes. Recombinant IL-8, IL-8...
Background Hemorrhagic fever with renal syndrome (HFRS) is caused by different hantaviruses within the Bunyaviridae family. HFRS a fulminant, infectious disease that occurs worldwide and endemic in all 31 provinces of China. Since first case Hubei Province was reported 1957, has spread across province become one seriously affected areas China greatest number cases 1980's. However, epidemic characteristics are still not entirely clear long-term, systematic investigations this area have been...
Herpes simplex virus type 1 (HSV-1), an enveloped DNA virus, plays a key role in varieties of diseases including recurrent cold sores, keratoconjunctivitis, genital herpes and encephalitis humans. Great efforts have been made developing more effective less side-effects anti-herpes agents, traditional Chinese herbal medicines. In the present study, we evaluated antiviral efficacy Rheum tanguticum nanoparticles against HSV-1 vitro vivo. R. could inactivate virions block viral attachment entry...
Abstract Background The human myxovirus resistance 2 (Mx2/MxB) protein was originally found to regulate cytoplasmic-nuclear transport but recently reported restrict HIV-1 replication by binding capsid (CA), preventing uncoating, the nuclear import of pre-integration complex (PIC) and viral DNA integration. This work explores mechanisms MxB-mediated inhibition. Results We demonstrated that MxB represses NUP358-mediated PIC replication. Moreover, MxB’s effects on depend critically cofactor...
BACKGROUND:At present, whether human cytomegalovirus (HCMV) infection is associated with type 2 diabetes mellitus (T2DM) debatable. The effect of active HCMV on glucose regulation has been poorly studied. Although correlated atherosclerosis in cardiovascular disease, the role development diabetic T2DM unclear and usually neglected by endocrinologists. aim this study was to assess effects patients. MATERIAL AND METHODS:A total 222 hospitalized patients were enrolled. Nested polymerase chain...
Coxsackievirus B(3)(CVB(3)) infection is the major cause of viral myocarditis, as well dilated cardiomypathy. Rhubarb one oldest and best-known traditional Chinese medicines. We initiated this study to determine antiviral effect an ethanol extract from roots rhizoma Rheum palmatum (R. palmatum, Rhubarbs), against CVB(3) in tissue culture cells a mouse model. The R. showed significant inhibitory activity on HEp-2 when added after infection, with IC(50) 4 μg/ml, TI 10. medicated serum still...