A5090012017- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Plant Gene Expression Analysis
- Plant biochemistry and biosynthesis
- Immunotherapy and Immune Responses
- Protein Degradation and Inhibitors
- RNA Interference and Gene Delivery
- Cytomegalovirus and herpesvirus research
- Mosquito-borne diseases and control
- Antioxidant Activity and Oxidative Stress
- Virus-based gene therapy research
- COVID-19 Clinical Research Studies
- interferon and immune responses
- Plant Molecular Biology Research
- Herpesvirus Infections and Treatments
- Neuropeptides and Animal Physiology
- Photosynthetic Processes and Mechanisms
- Phytoestrogen effects and research
- Lipoproteins and Cardiovascular Health
- Facial Nerve Paralysis Treatment and Research
- Viral Infections and Immunology Research
- Regulation of Appetite and Obesity
The University of Texas Medical Branch at Galveston
2016-2024
Sichuan University
2024
West China Hospital of Sichuan University
2024
Institute of High Energy Physics
2024
Chinese Academy of Sciences
2024
China Academy of Engineering Physics
2024
Fujian University of Technology
2024
Tea Research Institute
2024
Guangdong Academy of Agricultural Sciences
2024
China Spallation Neutron Source
2024
SARS-CoV-2 mRNA vaccination induces robust humoral and cellular immunity in the circulation; however, it is currently unknown whether elicits effective immune responses respiratory tract, particularly against variants of concern (VOCs), including Omicron. We compared S-specific total neutralizing antibody responses, B T cell immunity, bronchoalveolar lavage fluid (BAL) blood COVID-19-vaccinated individuals hospitalized patients. Vaccinated had significantly lower levels D614G, Delta...
Emergence of SARS-CoV-2 variants concern (VOCs), including the highly transmissible Omicron and Delta strains, has posed constant challenges to current COVID-19 vaccines that principally target viral spike protein (S). Here, we report a nucleoside-modified messenger RNA (mRNA) vaccine expresses more conserved nucleoprotein (mRNA-N) show mRNA-N vaccination alone can induce modest control SARS-CoV-2. Critically, combining with clinically proven S-expressing mRNA (mRNA-S+N) induced robust...
infection (CDI) is an urgent public health threat with limited preventative options. In this work, we developed a messenger RNA (mRNA)-lipid nanoparticle (LNP) vaccine targeting
Leucine-rich repeat receptor-like kinases (LRR-RLKs) represent a large class of proteins in regulating plant development and immunity. The LRR-RLK XA21 confers resistance to the bacterial disease caused by pathogen Xanthomonas oryzae pv. (Xoo). Several binding have been characterized, however early events governing signaling not fully elucidated.Here we report identification one gene (XIK1) whose expression is induced rapidly upon infection with Xoo. Expression pattern analysis reveals that...
HIV integrates its provirus into the host genome and establishes latent infection. Antiretroviral therapy (ART) can control viremia, but cannot eradicate or cure virus. Approaches targeting epigenetic machinery to repress HIV, leading an aviremic state free of ART, are needed. Bromodomain extraterminal (BET) family protein BRD4 is reader involved in transcriptional regulation. Using structure-guided drug design, we identified a small molecule (ZL0580) that induced suppression via BRD4. We...
Bromodomain-containing protein 4 (BRD4) is an emerging epigenetic drug target for intractable inflammatory disorders. The lack of highly selective inhibitors among BRD4 family members has stalled the collective understanding this critical system and progress toward clinical development effective therapeutics. Here we report discovery a potent bromodomain 1 (BD1)-selective inhibitor ZL0590 (52) targeting unique, previously unreported binding site, while exhibiting significant...
Abstract Salinity is one of the major abiotic stresses limiting rice production worldwide. Understanding genetic basis salinity tolerance key for breeding. In this study, a recombinant inbred line (RIL) population derived from super hybrid Liang–You–Pei–Jiu (LYP9) parents 93-11 and PA64s, exhibited variation in phenotypes including shoot length (SL), root (RL), fresh weight (SFW), (RFW), dry (SDW), (RDW) under 50 100 mM NaCl stress. QTL analysis identified total 38 QTLs these 6 traits two...
The COVID-19 pandemic has raised the standard regarding current vaccine development pace, as several messenger RNA (mRNA)-lipid nanoparticle (LNP) vaccines have proved their ability to induce strong immunogenicity and protective efficacy. We developed 1-methylpseudouridine-containing mRNA-LNP vaccines, expressing either more conserved SARS-CoV-2 nucleoprotein (mRNA-N) or spike protein (mRNA-S), both based on prototypic viral sequences. When combining mRNA-S mRNA-N together (mRNA-S+N), showed...
During the CoVID-19 pandemic, messenger ribonucleic acid (mRNA) vaccines were developed and approved to curb spread of coronavirus. After over 16 billion-dose-administration Pfizer-BioNTech-Fosun Moderna...
Abstract This review summarizes the mechanisms of hepatic glycolipid metabolism disorders caused by negative energy balance encountered in periparturient dairy cows and relevant research on nutritional additives as a therapeutic option. Factors such dietary management, hormonal regulation, overall metabolic stress body transition cow all contribute greatly to fatty liver formation. Nutritional strategies, using gluconeogenic precursors, growth factor, natural plant extracts, methyl donors...
Significance Efforts to develop an efficacious HIV vaccine have been unsuccessful date. Efficacy trials reported that recombinant Ad5 (rAd5)-HIV vaccines were not and unexpectedly associated with excess infection in recipients. Understanding the underlying mechanisms is urgent will further design. By comparing human CD4 T cells specific CMV, we report natural exposure- or vaccine-induced Ad5-specific are highly susceptible compared CMV-specific selectively manifest a Th17-like...
Glutaredoxins (GRXs) belong to the antioxidants involved in cellular stress responses. In spite of identification 48 GRX genes rice genomes, biological functions most them remain unknown. Especially, roles members family disease resistance are still lacking. Our proteomic analysis found that OsGRX20 increased by 2.7-fold after infection bacterial blight. this study, we isolated and characterized full-length nucleotide sequences gene, which encodes a protein with CPFC active site CPYC-type...
Endothelial cells (EC) are the main target for Orientia tsutsugamushi infection and EC dysfunction is a hallmark of severe scrub typhus in patients. However, molecular basis its impact on outcome poorly understood. We found that C57BL/6 mice received lethal dose O. Karp strain had significant increase expression IL-33 receptor ST2L kidneys liver, but rapid reduction lungs. also exacerbated stress activation infected mice, as evidenced by elevated angiopoietin (Ang) 2/Ang1 ratio, increased...
Abstract High‐sensitivity C‐reactive protein (hs‐ CRP ) and lipoprotein‐associated phospholipase A2 (Lp‐ PLA 2) have been reported to be independent predictors of atherosclerosis. However, whether the combination these two markers can improve prediction atherosclerosis is unknown. This study aimed evaluate association between combining hs‐ Lp‐ 2 predicting carotid A total 1982 participants aged ≥40 years were included in this study. Hs‐ measured by a high‐sensitivity nephelometry assay...
Abstract Viral vectors derived from different virus families, including poxvirus (canarypox vector ALVAC) and adenovirus (human Ad5 vector), have been widely used in vaccine development for a range of human diseases HIV/AIDS. Less is known about the mechanisms underlying host innate response to these vectors. Increasing evidence clinical trials testing viral has suggested importance understanding basic elements host–viral interactions. In this study, we investigated interactions APCs with...
The concerns raised from adenovirus 5 (Ad5)-based HIV vaccine clinical trials, where excess infections were observed in some recipients, have highlighted the importance of understanding host responses to vectors and susceptibility vector-specific CD4 T cells vaccination. Our recent study reported that human Ad5-specific induced by Ad5 vaccination (RV156A trial) are susceptible HIV. Here we further investigated ALVAC, a canarypox viral vector tested Thai trial RV144, as compared HVTN204...
Brain-resident microglia and perivascular macrophages are important HIV reservoirs in the CNS. Persistent viral replication latent reactivation CNS, even under ART, believed to occur, causing neuroinflammation neurological disorders HIV-infected patients. It is critical identify new approaches that can control residual and/or these reservoirs. We here report BRD4-selective small molecule modulator, ZL0580, induces potent durable suppression of human microglial monocytic cell lines. Using an...
The AP2/ERF transcription factors are widely involved in the regulation of plant growth, development and stress responses.
Chlorophyll, a green pigment in photosynthetic organisms, is generated by two distinct biochemical pathways, the tetrapyrrole biosynthetic pathway (TBP) and methylerythritol 4-phosphate (MEP) pathway. MEP one of pathways for isoprenoid synthesis plants, with 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (HDR) catalyzing its last step. In this study, we isolated green-revertible yellow leaf mutant gry3 rice cloned GRY3 gene, which encodes HDR participating geranylgeranyl (GGPP)...
Bacterial blight caused by Xanthomonas oryzae pv. (Xoo) is one of the most devastating diseases rice. However, molecular mechanism underpinning Xoo resistance rice still not fully understood. Here, we report that a class II small heat shock protein gene, OsHsp18.0, whose expression was differentially induced between resistant and susceptible variety in response to infection, plays positive roles both biotic abiotic resistance. The chaperone activity OsHsp18.0 confirmed bacterium-expressed...
Loss of immune control over opportunistic infections can occur at different stages HIV-1 (HIV) disease, among which mucosal candidiasis caused by the fungal pathogen Candida albicans (C. albicans) is one early and common manifestations in HIV-infected human subjects. The underlying immunological basis not well defined. We have previously shown that compared to cytomegalovirus (CMV)-specific CD4 cells, C. albicans-specific T cells are highly permissive HIV vitro. Here, based on an...