A5088862417- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Microscopic Colitis
- Eosinophilic Esophagitis
- Probiotics and Fermented Foods
- Helicobacter pylori-related gastroenterology studies
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Immune Response and Inflammation
- Nosocomial Infections in ICU
- Gastrointestinal motility and disorders
- Mycobacterium research and diagnosis
- T-cell and B-cell Immunology
- Immune responses and vaccinations
- Reproductive System and Pregnancy
- Pharmacological Effects of Natural Compounds
- Yersinia bacterium, plague, ectoparasites research
- Hematopoietic Stem Cell Transplantation
- Insect behavior and control techniques
- Bacterial Infections and Vaccines
- Asthma and respiratory diseases
- Bacteriophages and microbial interactions
- Insect symbiosis and bacterial influences
University of Pennsylvania
2012-2025
California University of Pennsylvania
2023
Memorial Sloan Kettering Cancer Center
2014-2016
Institute of Immunology
2014
Office of Infectious Diseases
2014
Loyola University Maryland
2006
Abstract Differentiation and maintenance of recirculating effector memory CD8 T cells (TEM) depends on prolonged cognate Ag stimulation. Whether similar pathways differentiation exist for recently identified tissue-resident (TRM), which contribute to rapid local protection upon pathogen re-exposure, is unknown. Memory CD8αβ+ within small intestine epithelium are well-characterized examples TRM, they maintain a long-lived effector-like phenotype that highly suggestive persistent This study...
The bZIP transcription factor Nfil3 (also known as E4BP4) is required for the development of natural killer (NK) cells and type 1 innate lymphoid (ILC1s). We find that plays a critical role in other mucosal tissue-associated lymphocytes. Type 3 ILCs (ILC3s), including tissue inducer (LTi)–like cells, are severely diminished both numbers function Nfil3-deficient mice. Using mixed bone marrow chimeric mice, we demonstrate normal gut-associated ILC3s cell-intrinsic manner. Furthermore,...
Seasonal epidemics of influenza virus result in ∼36,000 deaths annually the United States. Current vaccines against elicit an antibody response specific for envelope glycoproteins. However, high mutation rates emergence new viral serotypes, which elude neutralization by preexisting antibodies. T lymphocytes have been reported to be capable mediating heterosubtypic protection through recognition internal, more conserved, proteins. Here, we demonstrate using a recombinant expressing LCMV...
A synthetic TLR-7 agonist restores immune defenses to an antibiotic-resistant pathogen lost due antibiotic use.
Fecal microbiota transplantation (FMT) is a successful therapeutic strategy for treating recurrent Clostridioides difficile infection. Despite remarkable efficacy, implementation of FMT therapy limited and the mechanism action remains poorly understood. Here, we demonstrate critical role immune system in supporting using murine C. infection system. Following FMT, Rag1 heterozygote mice resolve while littermate Rag1-/- fail to clear Targeted ablation adaptive cell subsets reveal necessary...
infection (CDI) is an urgent public health threat with limited preventative options. In this work, we developed a messenger RNA (mRNA)-lipid nanoparticle (LNP) vaccine targeting
We have previously demonstrated that the circadian clock regulates host response to influenza A virus (IAV) infection, conferring a time-of-day-specific protection; infection at dawn resulted in threefold increase survival and reduced immunopathology compared dusk. While IL–10 is well-known for its immunoregulatory function, role IAV remains unclear, with studies reporting both protective detrimental effects. Given diurnal rhythmicity of receptor (Il10ra) expression lung, we investigated...
ABSTRACT Clostridioides difficile infects the large intestine and can result in debilitating potentially fatal colitis. The intestinal microbiota is a major factor influencing severity of disease following infection. Factors like diet that shape composition function may modulate C. Here, we report mice fed two distinct standard mouse chows (LabDiet 5010 LabDiet 5053) exhibited significantly different susceptibility to severe Both diets are grain-based with comparable profiles macro...
Clostridioides difficile infection causes pathology that ranges in severity from diarrhea to pseudomembranous colitis. Toxin A and B are the two primary virulence factors secreted by C. drive disease severity. The toxins damage intestinal epithelial cells leading a loss of barrier integrity induction proinflammatory host response. Monoclonal antibodies (mAbs) neutralize B, actoxumab bezlotoxumab, respectively, significantly reduce murine model infection. However, impact toxin neutralization...