A5011718692- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- RNA modifications and cancer
- Eosinophilic Esophagitis
- Cancer-related molecular mechanisms research
- Hepatitis B Virus Studies
- Virus-based gene therapy research
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Immune Response and Inflammation
- Prostate Cancer Treatment and Research
- Pediatric health and respiratory diseases
- Cancer, Hypoxia, and Metabolism
- Herpesvirus Infections and Treatments
- Poxvirus research and outbreaks
- Renal and related cancers
- Cytomegalovirus and herpesvirus research
- interferon and immune responses
- Reproductive System and Pregnancy
- Advanced Proteomics Techniques and Applications
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
University of Würzburg
2017-2025
Technical University of Munich
2009-2023
Institute of Medical Microbiology and Hygiene
2015-2020
University of Freiburg
2016-2020
University Medical Center Freiburg
2017-2020
Johannes Gutenberg University Mainz
2014-2019
Helmholtz Zentrum München
2008-2016
Memorial Sloan Kettering Cancer Center
2012-2016
Howard Hughes Medical Institute
2013-2016
Institute of Immunology
2014-2015
Innate lymphoid cells (ILCs) contribute to barrier immunity, tissue homeostasis, and immune regulation at various anatomical sites throughout the body. How ILCs maintain their presence in peripheral tissues thus far has been unclear. We found that nonlymphoid organs of adult mice, are tissue-resident were maintained expanded locally under physiologic conditions, upon systemic perturbation homeostasis during acute helminth infection. However, later time points after infection, from...
Trail+DX5−Eomes− natural killer (NK) cells arise in the mouse fetal liver and persist adult liver. Their relationships with Trail−DX5+ NK remain controversial. We generated a novel Eomes-GFP reporter murine model to address this question. found that Eomes− are not precursors of classical Eomes+ but rather constitute distinct lineage innate lymphoid cells. strictly dependent on both T-bet IL-15, similarly NKT observed that, liver, expression progenitors represses Eomes development...
The bZIP transcription factor Nfil3 (also known as E4BP4) is required for the development of natural killer (NK) cells and type 1 innate lymphoid (ILC1s). We find that plays a critical role in other mucosal tissue-associated lymphocytes. Type 3 ILCs (ILC3s), including tissue inducer (LTi)–like cells, are severely diminished both numbers function Nfil3-deficient mice. Using mixed bone marrow chimeric mice, we demonstrate normal gut-associated ILC3s cell-intrinsic manner. Furthermore,...
Background & AimsAntiviral agents suppress hepatitis B virus (HBV) replication but do not clear the infection. A strong effector T-cell response is required to eradicate HBV, this does occur in patients with chronic T cells might be directed toward virus-infected by expressing HBV-specific receptors and thereby HBV help prevent development of liver cancer. In mice, we studied whether redirected can engraft after adoptive transfer, without prior depletion, large amounts circulating viral...
Abstract Establishing and maintaining tolerance to self-antigens or innocuous foreign antigens is vital for the preservation of organismal health. Within thymus, medullary thymic epithelial cells (mTECs) expressing autoimmune regulator (AIRE) have a critical role in self-tolerance through deletion autoreactive T promotion regulatory (T reg ) cell development 1–4 . weeks birth, separate wave differentiation occurs periphery upon exposure derived from diet commensal microbiota 5–8 , yet types...
Abstract T cell exhaustion is a hallmark of cancer and persistent infections, marked by inhibitory receptor upregulation, diminished cytokine secretion, impaired cytolytic activity. Terminally exhausted cells are steadily replenished precursor population (Tpex), but the metabolic principles governing Tpex maintenance regulatory circuits that control their remain incompletely understood. Using combination gene-deficient mice, single-cell transcriptomics, metabolomic analyses, we show...
The emergence of the adaptive immune system took a toll in form pathologies mediated by self-reactive cells. Regulatory T cells (T reg cells) exert critical brake on responses and B lymphocytes to self- foreign antigens. Here, we asked whether are required restrain NK cells, third lymphocyte lineage, whose features combine innate cell properties. Although depletion led systemic fatal autoimmunity, tolerance reactivity strong activating non-self–ligands remained largely intact. In contrast,...
Development of the natural killer (NK) cell lineage is dependent on transcription factor Nfil3 (or E4BP4), which thought to act downstream IL-15 signaling. Nfil3-deficient mice lack NK cells, whereas other lymphocyte lineages (B, T, and NKT cells) remain largely intact. We report appearance Ly49H-expressing cells in Nfil3−/− infected with mouse cytomegalovirus (MCMV) or recombinant viruses expressing viral m157 glycoprotein. at peak antigen-driven expansion were functionally similar from...
Activation and expansion of T B lymphocytes myeloid cells are controlled by Foxp3+ regulatory (T reg cells), their deficiency results in a fatal lympho- myeloproliferative syndrome. A role for the homeostasis innate lymphocyte lineages remained unknown. Here, we report that restrained immature CD127+ NK cells, which had unique ability to up-regulate IL2Rα (CD25) response proinflammatory cytokine IL-12. In addition, observed preferential accumulation mice bearing progressing tumors or...
The strength of antiviral T cell responses correlates with clearance hepatitis B virus (HBV) infection, but the immunological mechanisms mitigating or suppressing HBV-specific cells are still poorly understood. In this study, we examined role CD4+ Foxp3+ regulatory (Tregs) in a mouse model acute HBV infection. We initiated infection via an adenoviral vector transferring 1.3-fold overlength genome (AdHBV) into transgenic DEREG mice, where Tregs can be transiently selectively depleted by...
Tissue-resident memory CD8+ T cells (TRM) constitute a major component of the immune-surveillance system in nonlymphoid organs. Local, noncognate factors are both necessary and sufficient to support programming TRM cell fate tissue-infiltrating cells. Recent evidence suggests that TCR signals received infected tissues additionally contribute formation. Here, we asked how antigen-dependent pathways influence generation skin-resident arise from polyclonal repertoire induced by infection with...
Upon viral infection, natural killer (NK) cells expressing certain germline-encoded receptors are selected, expanded, and maintained in an adaptive-like manner. Currently, these thought to differentiate along a common pathway. However, by fate mapping of single NK upon murine cytomegalovirus (MCMV) we identified two distinct cell lineages that contributed responses. One was equivalent conventional (cNK) while the other transcriptionally similar type 1 innate lymphoid (ILC1s). ILC1-like...