Thomas G. P. Grünewald
A5010237107- Sarcoma Diagnosis and Treatment
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- CAR-T cell therapy research
- Cancer, Lipids, and Metabolism
- Lymphoma Diagnosis and Treatment
- Protein Degradation and Inhibitors
- RNA Research and Splicing
- Virus-based gene therapy research
- Cancer-related molecular mechanisms research
- Cardiac tumors and thrombi
- Neuroblastoma Research and Treatments
- Cell Adhesion Molecules Research
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Congenital heart defects research
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Metabolism, Diabetes, and Cancer
- Combustion and Detonation Processes
- Risk and Safety Analysis
- PI3K/AKT/mTOR signaling in cancer
- Liver Disease Diagnosis and Treatment
- Ubiquitin and proteasome pathways
German Cancer Research Center
2016-2025
Heidelberg University
2016-2025
Hopp Children's Cancer Center Heidelberg
2020-2025
University Hospital Heidelberg
2020-2025
Deutschen Konsortium für Translationale Krebsforschung
2016-2025
National Center for Tumor Diseases
2022-2025
Children's Cancer Center
2022-2025
DKFZ-ZMBH Alliance
2025
LMU Klinikum
2017-2024
Ludwig-Maximilians-Universität München
2015-2024
Abstract Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents children. They represent a morphologically heterogeneous class of some entities lack defining histopathological features. Therefore, the diagnosis sarcomas is burdened with high inter-observer variability misclassification rate. Here, we demonstrate classification using machine learning classifier algorithm based on array-generated DNA methylation data. This sarcoma trained dataset 1077 profiles from...
Abstract Metastases are the leading cause of mortality in patients with cancer. Metastasis formation requires cancer cells to adapt their cellular phenotype. However, how metabolism supports this adaptation is poorly defined. We use 2D versus 3D cultivation induce a shift phenotype breast cells. discover that proline catabolism via dehydrogenase (Prodh) growth culture. Subsequently, we link vivo metastasis formation. In particular, find PRODH expression and increased metastases compared...
Under cell stress, global protein synthesis is inhibited to preserve energy. One mechanism sequester and silence mRNAs in ribonucleoprotein complexes known as stress granules (SGs), which contain translationally silent mRNAs, preinitiation factors, RNA-binding proteins. Y-box binding 1 (YB-1) localizes SGs, but its role SG biology unknown. We now report that YB-1 directly binds activates the 5′ untranslated region (UTR) of G3BP1 thereby controlling availability nucleator for assembly....
Abstract Establishing and maintaining tolerance to self-antigens or innocuous foreign antigens is vital for the preservation of organismal health. Within thymus, medullary thymic epithelial cells (mTECs) expressing autoimmune regulator (AIRE) have a critical role in self-tolerance through deletion autoreactive T promotion regulatory (T reg ) cell development 1–4 . weeks birth, separate wave differentiation occurs periphery upon exposure derived from diet commensal microbiota 5–8 , yet types...
EWSR1-FLI1, the chimeric oncogene specific for Ewing sarcoma (EwS), induces a cascade of signaling events leading to cell transformation. However, it remains elusive how genetically homogeneous EwS cells can drive heterogeneity transcriptional programs. Here, we combine independent component analysis single-cell RNA sequencing data from diverse types and model systems with time-resolved mapping EWSR1-FLI1 binding sites open chromatin regions characterize dynamic cellular processes associated...
Ewing tumors comprise the second most common type of bone-associated cancer in children and are characterized by oncogenic EWS/FLI1 fusion proteins early metastasis. Compelling evidence suggests that elevated levels intracellular oxidative stress contribute to enhanced aggressiveness numerous cancers, possibly including tumors. Using comprehensive microarray analyses RNA interference, we identified six-transmembrane epithelial antigen prostate 1 (STEAP1)-a membrane-bound mesenchymal stem...