A5049705661- Glioma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Spinal Dysraphism and Malformations
- Vascular Malformations Diagnosis and Treatment
- Meningioma and schwannoma management
- Neuroblastoma Research and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Brain Metastases and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Chromatin Remodeling and Cancer
- Fetal and Pediatric Neurological Disorders
- Neurofibromatosis and Schwannoma Cases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Neurosurgical Procedures and Complications
- Migration, Health and Trauma
- Assisted Reproductive Technology and Twin Pregnancy
- Hedgehog Signaling Pathway Studies
- Childhood Cancer Survivors' Quality of Life
- Testicular diseases and treatments
- Bacterial Infections and Vaccines
- Pituitary Gland Disorders and Treatments
- Infectious Diseases and Tuberculosis
- Gestational Trophoblastic Disease Studies
- Restraint-Related Deaths
National Neuroscience Institute
2016-2025
KK Women's and Children's Hospital
2016-2025
SingHealth Duke-NUS Academic Medical Centre
2017-2024
University of Toronto
2024
Duke-NUS Medical School
2021
SingHealth
2020
Community Partners
2015-2019
Quality Research
2006
Abstract Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents children. They represent a morphologically heterogeneous class of some entities lack defining histopathological features. Therefore, the diagnosis sarcomas is burdened with high inter-observer variability misclassification rate. Here, we demonstrate classification using machine learning classifier algorithm based on array-generated DNA methylation data. This sarcoma trained dataset 1077 profiles from...
Myanmar/Burma has received increased development and humanitarian assistance since the election in November 2010. Monitoring impact of foreign economic on health human rights requires knowledge pre-election conditions.From October 2008-January 2009, community-based organizations conducted household surveys using three-stage cluster sampling Shan, Kayin, Bago, Kayah, Mon Tanintharyi areas Myanmar. Data was collected from 5,592 heads demographics, reproductive health, diarrhea, births, deaths,...
ABSTRACT The stationary-phase sigma factor (RpoS) regulates many cellular responses to environmental stress conditions such as heat, acid, and alkali shocks. On the other hand, mutations at rpoS locus have frequently been detected among pathogenic well commensal strains of Escherichia coli . objective this study was perform a functional analysis RpoS-mediated enterohemorrhagic E. from food-borne outbreaks. belonging serotypes O157:H7, O111:H11, O26:H11 exhibited polymorphisms for two...
OBJECTIVE The number of pediatric neurosurgeons worldwide remains inadequate. Opportunities for fellowship training and continuing medical education in neurosurgery are limited, particularly low- middle-income countries. This study aimed to describe the setup conduct a recurring online meeting discuss diagnostic treatment dilemmas neurosurgery, organized by group Southeast Asia. METHODS Available reports since inception 2022 registration data year 2024 were analyzed. Meeting recordings...
Introduction: Pediatric craniopharyngiomas (CPG) are histologically benign but clinically complex tumors. Traditional mainstays of treatment include surgical resection and radiotherapy. Molecular insights report that children tend to have the adamantinomatous subtype is driven by CTNNB1 pathway while papillary CPGs prevalent in adult population characterized BRAFV600E mutations. Mixed histological subtypes rare. We an unusual case a pediatric CPG with both subtypes; discuss management...
BackgroundBurma/Myanmar was controlled by a military regime for over 50 years. Many basic social and protection services have been neglected, specifically in the ethnic areas. Development these areas led non-state actors to ensure care availability of health communities living border ethnic-controlled Political changes Burma/Myanmar ongoing since end 2010. Given diversity Burma/Myanmar, many challenges ensuring service coverage among all groups lie ahead.MethodsA case study method used...
Abstract Background This multinational study was conducted to report clinical presentations and treatment strategies in patients with intracranial germinomas across selected Asian centers, including failure patterns, risk factors, outcomes. Methods A retrospective data collection analysis of these patients, treated between 1995 2015 from eight healthcare institutions four countries undertaken. Results From the results, 418 were analyzed, a median follow-up 8.9 years; 79.9% M0, 87.6% had...
OBJECTIVE The introduction of ventriculoperitoneal shunts changed the way hydrocephalus was treated. Whereas much is known about causes shunt failure in first few years, there a paucity data literature regarding cause late failures. authors conducted study to find out different failures their institution. METHODS A 10-year retrospective all patients who were treated authors' hospital between 2006 and 2015 conducted. Late included those had undergo revision more than 5 years after initial...
Myanmar transitioned to a nominally civilian government in March 2011. It is unclear how, if at all, this political change has impacted migration the household level.We present household-level in- and out-migration data gathered during Eastern Burma Retrospective Mortality Survey (EBRMS) conducted 2013. Household level in-and information within previous year was via cross-sectional, retrospective, multi-stage population-based cluster randomized survey eastern Myanmar. Univariate, bivariate...
Assessment of cancer predisposition syndromes (CPS) in childhood tumours is challenging to paediatric oncologists due inconsistent recognizable clinical phenotypes and family histories, especially cohorts with unknown prevalence germline mutations. Screening checklists were developed facilitate CPS detection patients; however, their value have yet been validated. Our study aims assess the utility screening validated by genetic sequencing an Asian cohort tumours. We evaluated 102 patients...
The role of prophylactic detethering a fibrofatty filum terminale (FFT) remains equivocal. Furthermore, long-term studies focusing on urological outcomes are sparse. aims this study were to present an institutional experience the perioperative and FFT surgery assess for factors that contribute postoperative clean intermittent catheterization (CIC).
Abstract Background Metastatic medulloblastoma (MB) portends a poor prognosis. Amongst the 4 molecular subtypes, Group 3 and patients have higher incidence of metastatic disease, especially involving neuroaxis. At present, mechanisms underlying MB metastasis remain elusive. Separately, inflammation has been implicated as key player in tumour development metastasis. Cytokines their inflammation-related partners demonstrated to act on autocrine and, or paracrine pathways within...