A5027866102- Glioma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Prostate Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Testicular diseases and treatments
- Brain Metastases and Treatment
- Radiation Therapy and Dosimetry
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Lung Cancer Research Studies
- Meningioma and schwannoma management
- Bone Tumor Diagnosis and Treatments
- Chemokine receptors and signaling
- Neuroblastoma Research and Treatments
- Cardiac tumors and thrombi
- Hematopoietic Stem Cell Transplantation
- Teratomas and Epidermoid Cysts
- Management of metastatic bone disease
- Multiple and Secondary Primary Cancers
- Vascular Tumors and Angiosarcomas
- Effects of Radiation Exposure
- Ocular Oncology and Treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- Hematological disorders and diagnostics
National Cancer Centre Singapore
2015-2025
Florida College
2020-2023
University of Florida
2020-2023
National Cancer Centre Japan
2022
Duke-NUS Medical School
2019-2022
University of Florida Health
2022
Singapore General Hospital
2020
Purpose Retroperitoneal sarcomas (RPS) are rare tumors that present unique challenges, often due to late presentation, and the proximity of critical organs makes complete surgical resection challenging. This study aimed assess feasibility neoadjuvant short-course radiotherapy (SCRT) targeting margins-at-risk its potential impact on outcomes. Materials Methods is a single-center, prospective, non-randomized study. SCRT was administered via image-guided volumetric modulated arc therapy,...
Out-of-field neutron dissemination during double-scattered proton therapy has raised concerns of increased second malignancies, disproportionally affecting pediatric patients due to the proportion body exposed scatter dose and inherent radiosensitivity developing tissue. We sought provide empiric data on incidence early tumors.Between 2006 2019, 1713 consecutive children underwent therapy. Median age at treatment was 9.1 years; 371 were ≤3 years old. Thirty-seven (2.2%) had tumor...
Abstract Background This multinational study was conducted to report clinical presentations and treatment strategies in patients with intracranial germinomas across selected Asian centers, including failure patterns, risk factors, outcomes. Methods A retrospective data collection analysis of these patients, treated between 1995 2015 from eight healthcare institutions four countries undertaken. Results From the results, 418 were analyzed, a median follow-up 8.9 years; 79.9% M0, 87.6% had...
Abstract Background Metastatic medulloblastoma (MB) portends a poor prognosis. Amongst the 4 molecular subtypes, Group 3 and patients have higher incidence of metastatic disease, especially involving neuroaxis. At present, mechanisms underlying MB metastasis remain elusive. Separately, inflammation has been implicated as key player in tumour development metastasis. Cytokines their inflammation-related partners demonstrated to act on autocrine and, or paracrine pathways within...
(1) Background: Fluorescein sodium (Na-Fl) has been described as a safe and useful neurosurgical adjunct in adult neurooncology. However, its use yet to be fully established children. We designed study investigate the of intraoperative Na-Fl pediatric brain tumor surgery. (2) Methods: This is single-institution for patients managed by Neurosurgical Service, KK Women's Children's Hospital. Inclusion criteria consists undergoing surgery suspected tumors from 3 19 years old. A predefined...
Abstract Purpose Spinal myxopapillary ependymoma (MPE) often presents with a multifocal distribution, complicating attempts at resection. There remains no standard approach to irradiating these patients. We report disease control and toxicity in pediatric patients spinal MPE treated limited‐volume proton therapy. Materials/methods Twelve (≤21 years old) were between 2009 2018 brain‐sparing Median age was 13.5 (range, 7‐21). Radiotherapy given as adjuvant therapy after primary surgery five...
Androgen deprivation therapy (ADT) and radiotherapy (RT) are the mainstay treatment for localized prostate cancer recurrence after surgery. Cardiovascular (CV) toxicity of ADT is increasingly recognized, risk relates to pre-existing factors modalities. Despite ethnic differences in prevalence CV variations mortality, data on ADT-related cardiotoxicities Asian population remain inconclusive. Our registry-based study investigated major adverse cardiovascular events (MACE) primary or salvage...
To report the long-term clinical outcomes of low-risk (LR) and intermediate-risk (IR) prostate cancer patients treated with low-dose-rate brachytherapy (LDR-BT) external beam radiation therapy (EBRT).Men biopsy-proven low- received EBRT LDR-BT in an Asian academic center from 2000 to 2019 were reviewed. Kaplan-Meier survival analysis was performed compare biochemical failure-free (bFFS) overall (OS) between LDR cohorts.642 (521 121 LDR-BT) included for analysis. In group, 5- 10-year bFFS...
Radiation-associated angiosarcoma (RAAS) is a rare complication among patients treated with radiation therapy for breast cancer. Hyperfractionated-accelerated reirradiation (HART) improves local control after surgery. Proton may further improve the therapeutic ratio by mitigating potential toxicity.Six enrolled in prospective registry localized RAAS received HART proton between 2015 and 2021. was delivered twice or thrice daily fraction sizes of 1.5 1.0 Gy, respectively. All 45 Gy to large...
Background: Cutaneous angiosarcoma (AS) is an aggressive entity and commonly presents in the head neck region of elderly patients. We present our experience with various treatment modalities approaches herein. Methods: A retrospective chart review patients AS treated over a 20-year period single institution was undertaken. Results: total 88 mean age 74 years were included. Seventy-four had scalp primary. Thirty-one metastatic at diagnosis. The median overall survival (OS) for localized 6.9...
Purpose: Re-irradiation for bulky recurrent sarcoma carries significant risks. Pulsed low-dose rate radiotherapy (PLDR) is an attractive option re-irradiation due to inherent radiobiological advantages. Materials and Methods: We present two patients who underwent reirradiation using PLDR technique, followed by a literature review.Results: The first case that of 76-year-old male developed in-field recurrence pelvic bone high-grade chondrosarcoma after he was treated with definitive helical...
e293 Background: Second malignant neoplasms (SMNs) are a concern in survivors of childhood cancer. Chemotherapy forms the mainstay treatment for acute lymphoblastic leukaemia, but radiotherapy is used certain situations. As both chemotherapy and can be carcinogenic, patients treated with modalities may at higher risk SMNs. This study aims to investigate incidence SMNs radiotherapy. Methods: Children aged 16 years below diagnosed leukaemia from 1993 2014 were identified Childhood Cancer...
A 2-week-old girl with uncomplicated birth history presented 2 days of left eye swelling and 1 day fever. Physical examination showed ptosis, periorbital subtle proptosis (figure 1). Investigations revealed a raised blood leucocyte count 24.89×10(9)/L. Cerebrospinal fluid (CSF) analysis red cell 25/μL, white 3003/μL CSF:blood glucose ratio 0.48. Clinical impression was acute bacterial meningitis orbital cellulitis. She treated intravenous antibiotics …
The treatment of pediatric optic pathway gliomas (OPG) is challenging. At present, most centers provide individualized to maximize progression free survival (PFS) and minimize morbidity. We aim report our experience in the management OPG, investigate factors associated with an increased duration remission after treatment.This a single-institution study approved by hospital ethics board. A retrospective review consecutive OPGs managed from 2000 2020 was performed. Patients were divided into...