Francesca Rizzollo
A5060658897- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Immune cells in cancer
- Metabolism, Diabetes, and Cancer
- Immunotherapy and Immune Responses
- Calcium signaling and nucleotide metabolism
- Glycosylation and Glycoproteins Research
- Epigenetics and DNA Methylation
- interferon and immune responses
- Cancer, Lipids, and Metabolism
- RNA regulation and disease
- Mitochondrial Function and Pathology
- Erythrocyte Function and Pathophysiology
VIB-KU Leuven Center for Cancer Biology
2021-2025
KU Leuven
2021-2025
VIB-KU Leuven Center for Microbiology
2024
Vlaams Instituut voor Biotechnologie
2021
Tumor endothelial cells (TECs) actively repress inflammatory responses and maintain an immune-excluded tumor phenotype. However, the molecular mechanisms that sustain TEC-mediated immunosuppression remain largely elusive. Here, we show autophagy ablation in TECs boosts antitumor immunity by supporting infiltration effector function of T-cells, thereby restricting melanoma growth. In melanoma-bearing mice, loss TEC leads to transcriptional expression immunostimulatory/inflammatory phenotype...
A major therapeutic barrier in melanoma is the coexistence of diverse cellular states marked by distinct metabolic traits. Transitioning from a proliferative to an invasive phenotype coupled with increased ferroptosis vulnerability. However, regulatory circuits controlling susceptibility across cell are unknown. In this work, we identified Apolipoprotein E ( APOE ) as top lipid-metabolism gene segregating MITF high /AXL low proliferative/ferroptosis-resistant invasive/ferroptosis-sensitive...
<title>Abstract</title> Iron sustains cancer cell phenotypic and metabolic plasticity, yet it also sensitizes the mesenchymal/drug-tolerant persister phenotype to ferroptosis. This posits that iron compartmentalization must be tightly regulated. However, molecular machinery governing organelle Fe2+ remains elusive. Here, we identified Bdh2, mammalian homolog of bacterial EntA, as a key effector inter-organelle redistribution ferroptosis vulnerability during melanoma transition from...
ABSTRACT Tumor endothelial cells (TECs) actively repress inflammatory responses and maintain an immune-excluded tumor phenotype. However, the molecular mechanisms that sustain TEC-mediated immunosuppression remain largely elusive. Here, we show autophagy ablation in TECs boosts antitumor immunity by supporting infiltration effector function of T cells, thereby restricting melanoma growth. In melanoma-bearing mice, loss TEC leads to transcriptional expression immunostimulatory/inflammatory...
Abstract Cancer metastasis requires the transient activation of cellular programs enabling dissemination and seeding in distant organs. Genetic, transcriptional translational intra-tumor heterogeneity contributes to this dynamic process. Beyond this, metabolic has also been observed, yet its role for cancer progression remains largely elusive. Here, we discovered that phosphoglycerate dehydrogenase (PHGDH) protein expression drives breast cell formation. Specifically, observed heterogeneous...