Gosia Golda
A5102824770- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Cancer-related gene regulation
- Genetic Associations and Epidemiology
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- Eosinophilic Esophagitis
- Immunotherapy and Immune Responses
- Health, Environment, Cognitive Aging
- Immune cells in cancer
University of Würzburg
2023
Wellcome Sanger Institute
2022
Jagiellonian University
2020-2021
Max Planck Institute of Immunobiology and Epigenetics
2021
University of Freiburg
2021
Identifying cellular functions dysregulated by disease-associated variants could implicate novel pathways for drug targeting or modulation in cell therapies. However, follow-up studies can be challenging if disease-relevant types are difficult to sample. Variants associated with immune diseases point toward the role of CD4+ regulatory T cells (Treg cells). We mapped genetic regulation (quantitative trait loci [QTL]) gene expression and chromatin activity Treg cells, we identified 133...
Unlike macrophage networks composed of long-lived tissue-resident cells within specific niches, conventional dendritic (cDCs) that generate a 3D network in lymph nodes (LNs) are short lived and continuously replaced by DC precursors (preDCs) from the bone marrow (BM). Here, we examined whether anatomical niches exist which preDCs differentiate toward immature cDCs. In situ photoconversion Prtn3-based fate-tracking revealed LN medullary cords preferential entry sites for preDCs, serving as...
Cytosine modifications in DNA such as 5-methylcytosine (5mC) underlie a broad range of developmental processes, maintain cellular lineage specification, and can define or stratify types cancer other diseases. However, the wide variety approaches available to interrogate these has created need for harmonized materials, methods, rigorous benchmarking improve genome-wide methylome sequencing applications clinical basic research. Here, we present multi-platform assessment cross-validated...
Abstract Cytosine modifications in DNA such as 5-methylcytosine (5mC) underlie a broad range of developmental processes, maintain cellular lineage specification, and can define or stratify cancer other diseases. However, the wide variety approaches available to interrogate these has created need for harmonized materials, methods, rigorous benchmarking improve genome-wide methylome sequencing applications clinical basic research. Here, we present multi-platform assessment global resource...