A5013585406- Immune Cell Function and Interaction
- Immune cells in cancer
- T-cell and B-cell Immunology
- Neuroinflammation and Neurodegeneration Mechanisms
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- IL-33, ST2, and ILC Pathways
- Neurogenesis and neuroplasticity mechanisms
- Dermatology and Skin Diseases
- Cancer, Hypoxia, and Metabolism
- Hair Growth and Disorders
- Neuroscience and Neuropharmacology Research
- Apelin-related biomedical research
- Aldose Reductase and Taurine
- Skin Protection and Aging
- Wound Healing and Treatments
- Eosinophilic Esophagitis
- Bacterial biofilms and quorum sensing
- Signaling Pathways in Disease
- Bacterial Infections and Vaccines
- Chemokine receptors and signaling
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Response and Inflammation
- Lipid Membrane Structure and Behavior
- Pharmacological Effects of Natural Compounds
University of Bonn
2018-2024
Howard Hughes Medical Institute
2023-2024
University of California, San Francisco
2023-2024
University of Würzburg
2020-2023
CD8+ T cells that respond to chronic viral infections or cancer are characterized by the expression of inhibitory receptors such as programmed cell death protein 1 (PD-1) and impaired production cytokines. This state restrained functionality-which is referred exhaustion1,2-is maintained precursors exhausted (TPEX) express transcription factor (TCF1), self-renew give rise TCF1- effector cells3-6. Here we show long-term proliferative potential, multipotency repopulation capacity during...
Neutrophils communicate with each other to form swarms in infected organs. Coordination of this population response is critical for the elimination bacteria and fungi. Using transgenic mice, we found that neutrophils have evolved an intrinsic mechanism self-limit swarming avoid uncontrolled aggregation during inflammation. G protein-coupled receptor (GPCR) desensitization acts as a negative feedback control stop migration when they sense high concentrations self-secreted attractants...
Abstract T cell exhaustion is a hallmark of cancer and persistent infections, marked by inhibitory receptor upregulation, diminished cytokine secretion, impaired cytolytic activity. Terminally exhausted cells are steadily replenished precursor population (Tpex), but the metabolic principles governing Tpex maintenance regulatory circuits that control their remain incompletely understood. Using combination gene-deficient mice, single-cell transcriptomics, metabolomic analyses, we show...
Unlike macrophage networks composed of long-lived tissue-resident cells within specific niches, conventional dendritic (cDCs) that generate a 3D network in lymph nodes (LNs) are short lived and continuously replaced by DC precursors (preDCs) from the bone marrow (BM). Here, we examined whether anatomical niches exist which preDCs differentiate toward immature cDCs. In situ photoconversion Prtn3-based fate-tracking revealed LN medullary cords preferential entry sites for preDCs, serving as...
Pain, detected by nociceptors, is an integral part of injury, yet whether and how it can impact tissue physiology recovery remain understudied. Here, we applied chemogenetics in mice to locally activate dermal TRPV1 innervations naive skin found that triggered new regenerative cycling dormant hair follicles (HFs). This was preceded rapid apoptosis macrophages, mediated the neuropeptide calcitonin gene-related peptide (CGRP). activation also a macrophage-dependent induction osteopontin...
Abstract Chemokines are important signaling molecules in the immune and nervous system. Using a fluorescence reporter mouse model, we demonstrate that chemokine CCL17, ligand of receptor CCR4, is produced murine brain, particularly subset hippocampal CA1 neurons. We found basal expression Ccl17 neurons was strongly enhanced by peripheral challenge with lipopolysaccharide (LPS). LPS‐mediated induction hippocampus dependent on local tumor necrosis factor (TNF) signaling, whereas upregulation...
Myelin defects lead to neurological dysfunction in various diseases and normal aging. Chronic neuroinflammation often contributes axon-myelin damage these conditions can be initiated and/or sustained by perturbed myelinating glia. We have previously shown that distinct
Abstract The capacity to develop immunological memory is a hallmark of the adaptive immune system. To investigate role Samd3 for cellular responses and development , we generated conditional knock‐out mouse including fluorescent reporter huDTR cassette depletion Samd3‐expressing cells. expression was observed in NK cells CD8 T cells, which are known their specific function against intracellular pathogens like viruses. After acute viral infections, enriched within precursor frequency...
Abstract Objective Neuronal cell death and neuroinflammation are characteristic features of epilepsy, but it remains unclear whether neuronal as such is causative for the development epileptic seizures. To test this hypothesis, we established a novel mouse line permitting inducible ablation pyramidal neurons by inserting simian diphtheria toxin (DT) receptor (DTR) cDNA into Ccl17 locus. The chemokine CCL17 expressed in CA1 adult mice controlling microglial quiescence. Methods Seizure...
Summary Myelin defects lead to neurological dysfunction in various diseases and normal aging. Chronic neuroinflammation often contributes axon-myelin damage these conditions can be initiated and/or sustained by perturbed myelinating glia. We have previously shown that distinct mutations the PLP1 gene result neurodegeneration is largely driven adaptive immune cells. Here we characterize CD8 + CNS-associated T cells myelin mutants using single-cell transcriptomics identify population...
In thymus, the ablation of T cell receptor (TCR)-activated transcription factor NFATc1 or its inducible isoforms during double-negative (DN) stages thymocyte development leads to a marked increase in γδ thymocytes whereas αβ remains mostly unaffected. These are characterized by upregulation promyelocytic leukemia zinc-finger (PLZF), "master regulator" natural killer (NKT) development, and acquisition an NKT phenotype with higher survival rates. The suppressive function formation critically...
ABSTRACT Functional exhaustion of T cells in cancer and persistent infections is characterized by the upregulation inhibitory receptors, progressive decline cytokine secretion impaired cytolytic activity. Terminally exhausted are steadily replenished a precursor population (Tpex) with phenotypic features memory stem-like capacity to self-renew. However, metabolic principles Tpex maintenance regulatory circuits that control their progeny remain incompletely understood. Using combination...