A5052412266- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Rheology and Fluid Dynamics Studies
- Polymer crystallization and properties
- Eosinophilic Esophagitis
- T-cell and B-cell Immunology
- Polymer Nanocomposites and Properties
- Material Dynamics and Properties
- Ionic liquids properties and applications
- Peroxisome Proliferator-Activated Receptors
- Clostridium difficile and Clostridium perfringens research
- Cardiovascular Issues in Pregnancy
- Macrophage Migration Inhibitory Factor
- Thermodynamic properties of mixtures
- Blood Coagulation and Thrombosis Mechanisms
- Reproductive System and Pregnancy
- Autoimmune and Inflammatory Disorders Research
- Neonatal Respiratory Health Research
- Composite Material Mechanics
- Mesenchymal stem cell research
- Hematopoietic Stem Cell Transplantation
- Immune Response and Inflammation
- Microscopic Colitis
- Growth Hormone and Insulin-like Growth Factors
- Escherichia coli research studies
University of Würzburg
2019-2025
Nuremberg Hospital
2017-2022
University of Freiburg
1998-2020
University Medical Center Freiburg
2017-2020
Institute of Medical Microbiology and Hygiene
2017-2020
Friedrich-Loeffler-Institut
2020
Helmholtz Centre for Infection Research
2014-2019
Center for Experimental and Clinical Infection Research
2013-2019
Johannes Gutenberg University Mainz
2017
Klinikum Frankfurt Höchst
2011
Abstract Establishing and maintaining tolerance to self-antigens or innocuous foreign antigens is vital for the preservation of organismal health. Within thymus, medullary thymic epithelial cells (mTECs) expressing autoimmune regulator (AIRE) have a critical role in self-tolerance through deletion autoreactive T promotion regulatory (T reg ) cell development 1–4 . weeks birth, separate wave differentiation occurs periphery upon exposure derived from diet commensal microbiota 5–8 , yet types...
Metallocene catalysis was employed to prepare model polypropylenes (PP) with very high molecular weights and narrow weight distributions (MWDs) of Mw/Mn ≈ 2, typical for "single site" metallocene catalysts. The viscoelastic properties PP melts were investigated by means oscillatory rheometry. Arrhenius WLF equations applied the influence temperature on rheology. With polypropylene samples it became possible determine onset plateau zone, reflecting rubber-like PP. For first time moduli...
Charge transport is more efficient in polymerized than molecular ionic liquids.
Natural killer (NK) cells are present in the circulation and can also be found residing tissues, these populations exhibit distinct developmental requirements thought to differ terms of ontogeny. Here, we investigate whether circulating conventional NK (cNK) develop into long-lived tissue-resident (trNK) following acute infections. We that viral bacterial infections skin triggered recruitment cNK their differentiation Tcf1
Group 1 innate lymphoid cells (ILCs), which comprise both natural killer (NK) and ILC1s, are important effectors that can also positively negatively influence adaptive immune responses. The latter function is generally ascribed to the ability of NK recognize kill activated T cells. Here, we used multiphoton intravital microscopy in mouse models hepatitis B study intrahepatic behavior group ILCs their cross-talk with virus (HBV)–specific CD8 + We found hepatocellular antigen recognition by...
Natural killer (NK) cells are innate lymphocytes with the capacity to elicit adaptive features, including clonal expansion and immunological memory. Because signal transducer activator of transcription 5 (STAT5) is essential for NK cell development, roles this factor its upstream cytokines interleukin-2 (IL-2) IL-15 during infection have not been carefully investigated. In study, we investigate how STAT5 regulates viral infection. We demonstrate that induced in by IL-12 STAT4 early after...
Broadband dielectric spectroscopy, differential scanning calorimetry, rheology, and pulsed field gradient-nuclear magnetic resonance (PFG NMR) are combined to study glassy dynamics charge transport in a homologous series of imidazole-based liquids with systematic variation the alkyl chain length. The spectra interpreted terms dipolar relaxation conductivity contribution. By applying Einstein, Einstein-Smoluchowski, Stokes-Einstein relations, translational diffusion coefficients--in...
Group 1 innate lymphoid cells (ILCs) comprising circulating natural killer (cNK) and tissue-resident ILC1s are critical for host defense against pathogens tumors. Despite a growing understanding of their role in homeostasis disease, the ontogeny group ILCs remains largely unknown. Here, we used fate mapping single-cell transcriptomics to comprehensively investigate origin turnover murine ILCs. Whereas cNK continuously replaced throughout life, uncovered tissue-dependent development ILC1s. A...
Abstract Hartstoffe werden im Verschleißschutz von Werkzeugen und Bauteilen wegen ihres hohen abrasiven Verschleißwiderstands eingesetzt, meist als Beschichtung Schichtdickenbereich nur einigen μm. Für eine Auswahl des Schichtmaterials sind die physikalischen, mechanischen technologischen Eigenschaften, in der jeweiligen Anwendung gefordert werden, ausschlaggebend. Dieser Beitrag stellt grundlegenden verfügbaren Daten ca. 130 Hartstoffen Ergebnisauswahl einer Literaturrecherche für Karbide,...
MyD88-mediated signaling downstream of Toll-like receptors and the IL-1 receptor family is critically involved in induction protective host responses upon infections. Although it known that MyD88-deficient mice are highly susceptible to a wide range bacterial infections, cell type-specific contribution MyD88 protecting against intestinal infection only poorly understood. In order investigate importance specific immune nonimmune types during infection, we employed novel murine knock-in model...
Abstract Macrophage activation syndrome (MAS) exemplifies a severe cytokine storm disorder with liver inflammation. In the liver, classical natural killer (cNK) cells and liver‐resident type 1 innate lymphoid (ILC1s) dominate ILC population. Thus far, research has primarily focused on corresponding role of cNK cells. Considering inflammation in MAS, ILC1s represent an interesting population to explore due their rapid production upon environmental triggers. By utilizing Toll‐like receptor...
Group 1 innate lymphoid cells (ILCs) encompass NK and ILC1s, which have non-redundant roles in host protection against pathogens cancer. Despite their circulating nature, can establish residency selected tissues during ontogeny, forming a distinct functional subset. The mechanisms that initiate, maintain, regulate the conversion of into tissue-resident (trNK) are currently not well understood. Here, we identify autocrine transforming growth factor-β (TGF-β) as cell-autonomous driver for cell...
Vasoinhibin is an antiangiogenic, profibrinolytic peptide generated by the proteolytic cleavage of pituitary hormone prolactin cathepsin D, matrix metalloproteinases, and bone morphogenetic protein-1. can also be when placental lactogen or growth are enzymatically cleaved. Here, it investigated whether plasmin cleaves human to generate vasoinhibin-like peptides. Co-incubation with was performed analyzed gel electrophoresis Western blotting. Mass spectrometric analyses were carried out for...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTESR and fluorescence polarization investigation of molecular motions in poly(vinylidene fluoride) some related copolymersC. Noel, F. Laupretre, C. Friedrich, Leonard, J. L. Halary, MonnerieCite this: Macromolecules 1986, 19, 1, 201–210Publication Date (Print):January 1986Publication History Published online1 May 2002Published inissue 1 January 1986https://pubs.acs.org/doi/10.1021/ma00155a032https://doi.org/10.1021/ma00155a032research-articleACS...