A5003503263- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Gut microbiota and health
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Clostridium difficile and Clostridium perfringens research
- Neutropenia and Cancer Infections
- Acute Myeloid Leukemia Research
- Cytomegalovirus and herpesvirus research
- Acute Lymphoblastic Leukemia research
- Microscopic Colitis
- Mycobacterium research and diagnosis
- Cancer Immunotherapy and Biomarkers
- Genomics, phytochemicals, and oxidative stress
- Renal Transplantation Outcomes and Treatments
- Oral health in cancer treatment
- Polyomavirus and related diseases
- Lymphoma Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
- Chronic Lymphocytic Leukemia Research
- Clinical Nutrition and Gastroenterology
- Immunodeficiency and Autoimmune Disorders
- Virus-based gene therapy research
- Mesenchymal stem cell research
Memorial Sloan Kettering Cancer Center
2016-2025
Cornell University
2016-2025
City Of Hope National Medical Center
2024-2025
City of Hope
2024-2025
Helios Dr. Horst Schmidt Kliniken Wiesbaden
2025
Beckman Research Institute
2025
Kettering University
2014-2024
Parker Institute for Cancer Immunotherapy
2023-2024
Weill Cornell Medicine
2022-2024
Princess Máxima Center
2024
Acute myeloid leukemia (AML) is a heterogeneous disease with respect to presentation and clinical outcome. The prognostic value of recently identified somatic mutations has not been systematically evaluated in phase 3 trial treatment for AML.We performed mutational analysis 18 genes 398 patients younger than 60 years age who had AML were randomly assigned receive induction therapy high-dose or standard-dose daunorubicin. We validated our findings an independent set 104 patients.We at least...
Bacteremia is a frequent complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). It unclear whether changes in the intestinal microbiota during allo-HSCT contribute to development bacteremia. We examined patients undergoing allo-HSCT, and correlated microbial shifts with risk bacteremia.Fecal specimens were collected longitudinally from 94 before transplant until 35 days after transplant. The was characterized by 454 pyrosequencing V1-V3 region bacterial 16S ribosomal...
Bloodstream infection by highly antibiotic-resistant bacteria, such as vancomycin-resistant Enterococcus (VRE), is a growing clinical problem that increasingly defies medical intervention. Identifying patients at high risk for bacterial sepsis remains an important challenge. Recent studies have shown antibiotics can alter microbial diversity in the intestine. Here, we characterized these effects using 16s rDNA pyrosequencing and demonstrated antibiotic treatment of mice enabled exogenously...
The relationship between intestinal microbiota composition and acute graft-versus-host disease (GVHD) after allogeneic blood/marrow transplantation (allo-BMT) is not well understood. Intestinal bacteria have long been thought to contribute GVHD pathophysiology, but recent animal studies in nontransplant settings found that anti-inflammatory effects are mediated by certain subpopulations of commensals. Hypothesizing a more nuanced may exist the GVHD, we evaluated fecal bacterial 64 patients...
Despite a growing understanding of the link between intestinal inflammation and resident gut microbes, longitudinal studies human flora before initial onset have not been reported. Here, we demonstrate in murine recipients allogeneic bone marrow transplantation (BMT) that secondary to graft-versus-host disease (GVHD) is associated with major shifts composition microbiota. The microbiota, turn, can modulate severity inflammation. In mouse models GVHD, observed loss overall diversity expansion...
Relationships between microbiota composition and clinical outcomes after allogeneic hematopoietic-cell transplantation have been described in single-center studies. Geographic variations the of human microbial communities differences practices across institutions raise question whether these associations are generalizable.
Treating neutropenic fever with broad-spectrum antibiotics after allogeneic hematopoietic stem cell transplant is associated an increase in graft-versus-host disease mice and humans.
ABSTRACT Bacteria causing infections in hospitalized patients are increasingly antibiotic resistant. Classical infection control practices only partially effective at preventing spread of antibiotic-resistant bacteria within hospitals. Because the density intestinal colonization by highly bacterium vancomycin-resistant Enterococcus (VRE) can exceed 10 9 organisms per gram feces, even optimally implemented hygiene protocols often fail. Decreasing colonization, therefore, represents an...
Ionizing radiation causes acute syndrome, which leads to hematopoietic, gastrointestinal, and cerebrovascular injuries. We investigated a population of mice that recovered from high-dose live normal life spans. These "elite-survivors" harbored distinct gut microbiota developed after protected against radiation-induced damage death in both germ-free conventionally housed recipients. Elevated abundances members the bacterial taxa
Endogenous thymic regeneration is a crucial function that allows for renewal of immune competence after stress, infection, or immunodepletion. However, the mechanisms governing this remain poorly understood. We detail such mechanism, centered on interleukin-22 (IL-22) and triggered by depletion CD4(+)CD8(+) double-positive thymocytes. Intrathymic levels IL-22 were increased insult, recovery was impaired in IL-22-deficient mice. IL-22, which signaled through epithelial cells promoted their...
A randomized clinical trial demonstrates that autologous fecal microbiota transplant can reconstitute the gut of patients undergoing intensive antibiotic treatment.
Purpose The major causes of mortality after allogeneic hematopoietic-cell transplantation (allo-HCT) are relapse, graft-versus-host disease (GVHD), and infection. We have reported previously that alterations in the intestinal flora associated with GVHD, bacteremia, reduced overall survival allo-HCT. Because bacteria potent modulators systemic immune responses, including antitumor effects, we hypothesized components could be relapse Methods microbiota 541 patients admitted for allo-HCT was...