A5088663166- Gut microbiota and health
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Inflammasome and immune disorders
- Clostridium difficile and Clostridium perfringens research
- Cancer-related molecular mechanisms research
- Gastrointestinal motility and disorders
- Extracellular vesicles in disease
- Horticultural and Viticultural Research
- Probiotics and Fermented Foods
- Animal Nutrition and Physiology
- Powdery Mildew Fungal Diseases
- Diet and metabolism studies
- Helicobacter pylori-related gastroenterology studies
- Fungal Plant Pathogen Control
- Nutritional Studies and Diet
- Ferroptosis and cancer prognosis
- interferon and immune responses
- Liver Disease Diagnosis and Treatment
- Effects of Radiation Exposure
- Angiogenesis and VEGF in Cancer
- Antimicrobial Peptides and Activities
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic function and diabetes
- Ginseng Biological Effects and Applications
Chinese Academy of Agricultural Sciences
2019-2025
Dali University
2024-2025
Zhejiang University
2024-2025
Zhejiang Lab
2024-2025
Second Affiliated Hospital of Zhejiang University
2024-2025
AbbVie (United States)
2021-2024
Fudan University
2015-2024
Nanjing Medical University
2015-2024
Jiangsu Province Hospital
2015-2024
First Affiliated Hospital of Kunming Medical University
2024
Ionizing radiation causes acute syndrome, which leads to hematopoietic, gastrointestinal, and cerebrovascular injuries. We investigated a population of mice that recovered from high-dose live normal life spans. These "elite-survivors" harbored distinct gut microbiota developed after protected against radiation-induced damage death in both germ-free conventionally housed recipients. Elevated abundances members the bacterial taxa
Caffeic acid (CA) is one of the major phenolic acids coffee with multiple biological activities. Our previous study found that 500 mg/kg chlorogenic (CGA) had potential capacity alleviating colonic inflammation. Moreover, CGA can be degraded into caffeic by gut microbiota in colon. Therefore, we hypothesize CA exert protective effects on To test hypothesis, 251 was supplemented to DSS-induced colitis mice. The results showed treatment recovered disease activity index (DAI), colon length, and...
Mesenchymal stem cells (MSCs) are non-hematopoietic with the capacity to differentiate into tissues of both mesenchymal and non-mesenchymal origin.MSCs can osteoblastic, chondrogenic, adipogenic lineages, although recent studies have demonstrated that MSCs also able other including neuronal cardiomyogenic lineages.Since their original isolation from bone marrow, been successfully harvested many tissues.Their ease ex vivo expansion combined immunoprivileged nature has made these popular...
Mesenchymal stem cells (MSCs) are bone marrow stromal that can differentiate into multiple lineages. We previously demonstrated BMP9 is one of the most potent BMPs to induce osteogenic differentiation MSCs. least studied BMPs. Whereas ALK1, ALK5, and/or endoglin have recently been reported as potential type I receptors in endothelial cells, little known about receptor involvement BMP9-induced Here, we conduct a comprehensive analysis functional role seven signaling found expressed However,...
Considerable attention and an enormous amount of resources have been dedicated to cancer biomarker discovery validation.However, there are still a limited number useful biomarkers available for clinical use.An ideal should be easily assayed with minimally invasive medical procedures but possess high sensitivity specificity.Commonly used circulating proteins in serum, most which require labor-intensive analysis hindered by low early tumor detection.Since the deregulation microRNA (miRNA) is...
Resident microbiota activate regulatory cells that modulate intestinal inflammation and promote maintain homeostasis. IL-10 is a key mediator of immune function. Our studies described the functional importance mechanisms by which gut specific microbial components influenced development IL-10-producing B cells. We used fecal transplant to germ-free (GF) Il10+/EGFP reporter Il10-/- mice demonstrate from pathogen-free primarily stimulated colon-specific T regulatory-1 in ex-GF mice. turn...
Breast cancer is considered as a heterogeneous disease comprising various types of neoplasms, which involves different profile changes in both mRNA and micro-RNA (miRNA) expression.Extensive studies on expression breast tumor have yielded some very interesting findings, been validated used clinic.Recent miRNA research advances showed great potential for the development novel biomarkers therapeutic targets.miRNAs are new class small non-coding regulatory RNAs that involved regulating gene at...
Background Idiopathic pulmonary arterial hypertension (IPAH) is a rare disease with high heritability. Although several predisposing genes have been linked to IPAH, the genetic aetiology remains unknown for large number of IPAH cases. Methods We conducted an exome-wide gene-based burden analysis on two independent case–control studies, including total 331 cases and 10 508 controls. Functional assessments were analyse effects mutations protein biosynthesis function. Results The gene encoding...
// Rongrong Liu 1,2,* , Agnieszka D. Truax 2,* Liang Chen 2 Peizhen Hu 3 Zengshan Li Jun 4 Chaojun Song 1 Lihua and Jenny Pan-Yun Ting 2,5 Department of Immunology, School Basic Medicine, Fourth Military Medical University, Xi’an, China The Lineberger Comprehensive Cancer Center, University North Carolina at Chapel Hill, NC, USA Pathology, Xijing Hospital, Encephalopathy, Traditional Chinese Medicine Hospital Shan Xi Province, 5 Departments Genetics, Microbiology-Immunology, * These...
MicroRNAs (miRNAs) contribute to cancer initiation and progression by silencing the expression of their target genes, causing either mRNA molecule degradation or translational inhibition. Intraductal epithelial proliferations breast are histologically clinically classified into normal, atypical ductal hyperplasia (ADH), carcinoma in situ (DCIS) invasive (IDC). To better understand development, we attempt identify deregulated miRNAs this process using Formalin-Fixed, Paraffin-Embedded (FFPE)...
// Xiaohui Tan 1 , Yebo Fu Liang Chen Woojin Lee Yinglei Lai 2 Katayoon Rezaei 3 Sana Tabbara Patricia Latham Christine B. Teal 4 Yan-Gao Man 5 Robert S. Siegel 6 Rachel F. Brem 7 Sidney W. Department of Medicine (Division Genomic Medicine), The George Washington University School and Health Sciences, Washington, DC, USA Statistics, University, Pathology, Surgery, Research Lab International Collaboration, Bon Secours Cancer Institute, System, Richmond, VA, Hematology/Oncology), Radiology,...
Xylo-oligosaccharides (XOS) is a well-known kind of oligosaccharide and extensively applied as prebiotic. The objective this study was to investigate the effect XOS supplementation substituting chlortetracycline (CTC) on growth, gut morphology, microbiota, hindgut short chain fatty acid (SCFA) contents weaning piglets. A total 180 weaned piglets were randomly allocated three treatments for 28 days, follows: control group (basal diet, CON), basal diet with 500 mg/kg (XOS500) XOS, positive 100...
Pectin is a heteropolysaccharide that acts as an intestinal immunomodulator, promoting development and regulating flora in the gut. However, relevant mechanisms remain obscure. In this study, pigs were fed corn-soybean meal-based diet supplemented with either 5% microcrystalline cellulose (MCC) or pectin for 3 weeks, to investigate metabolites anti-inflammatory properties of jejunum.The results showed dietary supplementation improved integrity (Claudin-1, Occludin) inflammatory response...
The Wnt/β-catenin pathway is involved in diverse cell functions governing development and disease. β-Catenin, a central mediator of this pathway, binds to members the TCF/LEF family transcription factors modulate hundreds genes. Active Wnt/β-catenin/TCF-4 signaling plays significant role repression HIV-1 replication multiple targets, including astrocytes. To determine mechanism by which active β-catenin/TCF-4 leads inhibition HIV replication, we knocked down β-catenin or primary astrocytes...
One carbon (1C) metabolism nutrients influence epigenetic regulation and they are supplied by diet synthesized gut microbiota. We examined the association between dietary consumption of methyl donors (methionine, betaine choline) B vitamins (folate, B2, B6, B12) community composition structure colonic mucosa-associated microbiota determined 16S rRNA gene sequencing in 97 biopsies 35 men. used food frequency questionnaire to assess daily nutrients, UPARSE SILVA databases for operational...
Abstract Background Circular RNAs (circRNAs) have been associated with bladder cancer (BC), but the specific underlying molecular mechanism of their association BC development has not fully explored. Methods Levels Circ_0008532, MTGR1 and miR-155-5p/miR-330-5p in cell lines tissues were determined quantitative real-time PCR western blotting assays. In vitro vivo assays performed to investigate function circ_0008532 tumorigenesis cells. The relationships predicted using bioinformatic tools...
Tibetan pigs were thought to have good performances of rough feeding tolerance, which may be related the gut microbiota. This study was conducted investigate changes colonic microbiota contribute fiber utilization in fed alfalfa supplementation diet compared with basal diet, and verified whether microbial community beneficial utilize using vitro fermentation. A total 40 allocated into two groups a corn-soybean meal (CD) or 50% (AD) for 42d. Our results showed CD improved carcass weight AD (p...
As pectin is widely used as a food and feed additive due to its tremendous prebiotic potentials for gut health. Yet, the underlying mechanisms associated with protective effect remain unclear. Twenty-four piglets (Yorkshire × Landrace, 6.77 ± 0.92 kg) were randomly divided into three groups eight replicates per treatment: (1) Control group (CON), (2) Lipopolysaccharide-challenged (LPS), (3) Pectin-LPS (PECL). Piglets administrated LPS or saline on d14 21 of experiment. in each fed...