Anthony D. Sung
A5063907259- Hematopoietic Stem Cell Transplantation
- Neutropenia and Cancer Infections
- Gut microbiota and health
- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Polyomavirus and related diseases
- Clostridium difficile and Clostridium perfringens research
- Cancer survivorship and care
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Frailty in Older Adults
- Mycobacterium research and diagnosis
- Cancer-related cognitive impairment studies
- Oral health in cancer treatment
- Renal Transplantation Outcomes and Treatments
- Nutrition and Health in Aging
- Multiple Myeloma Research and Treatments
- Clinical Nutrition and Gastroenterology
- Palliative Care and End-of-Life Issues
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Diabetic Foot Ulcer Assessment and Management
- Economic and Financial Impacts of Cancer
- Respiratory viral infections research
Duke University
2016-2025
Duke University Hospital
2019-2025
Duke Medical Center
2016-2025
University of Kansas Medical Center
2024-2025
University Medical Center
2025
University of Kansas
2024
Duke Cancer Institute
2017-2022
Duke University Health System
2022
University of North Carolina Health Care
2022
World Health Organization - Pakistan
2021
Relationships between microbiota composition and clinical outcomes after allogeneic hematopoietic-cell transplantation have been described in single-center studies. Geographic variations the of human microbial communities differences practices across institutions raise question whether these associations are generalizable.
Ionizing radiation causes acute syndrome, which leads to hematopoietic, gastrointestinal, and cerebrovascular injuries. We investigated a population of mice that recovered from high-dose live normal life spans. These "elite-survivors" harbored distinct gut microbiota developed after protected against radiation-induced damage death in both germ-free conventionally housed recipients. Elevated abundances members the bacterial taxa
Purpose The major causes of mortality after allogeneic hematopoietic-cell transplantation (allo-HCT) are relapse, graft-versus-host disease (GVHD), and infection. We have reported previously that alterations in the intestinal flora associated with GVHD, bacteremia, reduced overall survival allo-HCT. Because bacteria potent modulators systemic immune responses, including antitumor effects, we hypothesized components could be relapse Methods microbiota 541 patients admitted for allo-HCT was...
Disruption of intestinal microbial communities appears to underlie many human illnesses, but the mechanisms that promote this dysbiosis and its adverse consequences are poorly understood. In patients who received allogeneic hematopoietic cell transplantation (allo-HCT), we describe a high incidence enterococcal expansion, which was associated with graft-versus-host disease (GVHD) mortality. We found
Acute myelogenous leukemia (AML) patients with FLT3/ITD mutations have an inferior survival compared to AML wild-type (WT) FLT3, primarily because of increased relapse rate. Allogeneic transplantation represents a postremission therapy that is effective at reducing the risk for many cases poor-risk AML. Whether or not allogeneic in first complete remission (CR) can improve outcomes remains controversial. Our institution has adopted policy pursuing transplantation, including use alternate...
Respiratory viral infections (RVIs) are frequent complications of hematopoietic stem cell transplant (HSCT). Surgical masks a simple and inexpensive intervention that may reduce nosocomial spread.In this prospective single-center study, we instituted universal surgical mask policy requiring all individuals with direct contact HSCT patients to wear mask, regardless symptoms or season. The primary endpoint was the incidence RVIs in period (2010-2014) compared premask (2003-2009).RVIs decreased...
Between 1979 and 2004, 167 patients younger than 20 years were treated surgically for humeral or femoral unicameral bone cysts with either injection of corticosteroids (steroids), curettage plus grafting (curettage), a combination steroids, demineralized matrix, marrow aspirate (SDB) at Children's Hospital Boston Massachusetts General (mean followup, 7.3 years; range, 1 month-27 years). Outcomes included treatment failure (defined clinically as subsequent pathologic fracture need retreatment...
Patients undergoing hematopoietic stem cell transplant (HSCT) are at risk for bloodstream infection (BSI) secondary to translocation of bacteria through the injured mucosa, termed mucosal barrier injury-laboratory confirmed (MBI-LCBI), in addition BSI indwelling catheters and other sites (BSI-other).To determine incidence, timing, factors, outcomes patients who develop MBI-LCBI first 100 days after HSCT.A case-cohort retrospective analysis was performed using data from Center International...
Microbial diversity is associated with improved outcomes in recipients of allogeneic hematopoietic cell transplantation (allo-HCT), but the mechanism underlying this observation unclear. In a cohort 174 patients who underwent allo-HCT, we demonstrate that diverse intestinal microbiome early after allo-HCT an increased number innate-like mucosal-associated invariant T (MAIT) cells, which are turn overall survival and less acute graft-versus-host disease (aGVHD). Immune profiling conventional...
Abstract Purpose: The gut microbiota is subject to multiple insults in allogeneic hematopoietic cell transplantation (allo-HCT) recipients. We hypothesized that preparative conditioning regimens contribute perturbation allo-HCT. Experimental Design: This was a retrospective study evaluated the relationship between exposure 1,188 allo-HCT recipients and microbiome. Stool samples collected from 20 days before up 30 after were profiled using 16S rRNA sequencing. Microbiota injury quantified by...
The COVID-19 pandemic continues to pose unprecedented challenges worldwide health. While vaccines are effective, additional strategies mitigate the spread/severity of continue be needed. Emerging evidence suggests susceptibility respiratory tract infections in healthy subjects can reduced by probiotic interventions; thus, probiotics may a low-risk, low-cost, and easily implementable modality reduce risk COVID-19.
Certain anaerobic bacteria are important for maintenance of gut barrier integrity and immune tolerance may influence the risk graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT). We conducted a single-center retrospective cohort study HSCT recipients to evaluate associations between receipt antibiotics with an spectrum activity GVHD outcomes. identified 1214 children adults who developed febrile neutropenia 7 days before 28 compared mortality...
Insured patients with cancer face high treatment-related, out-of-pocket (OOP) costs and often cannot access financial assistance. We conducted a randomized, controlled trial of Bridge, patient-facing app designed to identify eligible resources for patients. hypothesized that using Bridge would experience greater OOP cost reduction than controls.We enrolled who had expenses from January 2018 March 2019. randomly assigned 1:1 intervention (Bridge) versus control (financial assistance...