A5087681431- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Effects of Radiation Exposure
- Influenza Virus Research Studies
- Bacillus and Francisella bacterial research
- COVID-19 Clinical Research Studies
- Reproductive tract infections research
- Hematopoietic Stem Cell Transplantation
- Bacterial Infections and Vaccines
- Animal Virus Infections Studies
- SARS-CoV-2 detection and testing
- Adrenal Hormones and Disorders
- interferon and immune responses
- Viral gastroenteritis research and epidemiology
- HIV Research and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Respiratory viral infections research
- Viral Infections and Outbreaks Research
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- RNA Interference and Gene Delivery
- Myasthenia Gravis and Thymoma
RTI International
2023-2025
Duke University Hospital
2002-2024
Duke Medical Center
2014-2024
Duke University
2015-2024
Durham VA Medical Center
2024
International Vaccine Institute
2002-2024
Augsburg University
2022
Duke Institute for Health Innovation
2020
Durham University
2014-2015
Fred Hutch Cancer Center
2012
Ionizing radiation causes acute syndrome, which leads to hematopoietic, gastrointestinal, and cerebrovascular injuries. We investigated a population of mice that recovered from high-dose live normal life spans. These "elite-survivors" harbored distinct gut microbiota developed after protected against radiation-induced damage death in both germ-free conventionally housed recipients. Elevated abundances members the bacterial taxa
Applied BiosafetyVol. 25, No. 2 Letters to the EditorFree AccessDecontamination and Reuse of N95 Respirators with Hydrogen Peroxide Vapor Address Worldwide Personal Protective Equipment Shortages During SARS-CoV-2 (COVID-19) PandemicAntony Schwartz, Matthew Stiegel, Nicole Greeson, Andrea Vogel, Wayne Thomann, Monte Brown, Gregory D. Sempowski, Thomas Scott Alderman, James Patrick Condreay, Burch, Cameron Wolfe, Becky Smith, Sarah LewisAntony SchwartzCorresponding Author: Antony Duke...
Severe acute respiratory syndrome coronaviruses 1 (SARS-CoV) and 2 (SARS-CoV-2), including SARS-CoV-2 variants of concern, can cause deadly infections. The mortality associated with sarbecovirus infection underscores the importance developing broadly effective countermeasures against them, which could be key in prevention mitigation current future zoonotic events. Here, we demonstrate neutralization SARS-CoV; bat WIV-1 RsSHC014; D614G, B.1.1.7, B.1.351, P.1, B.1.429, B.1.526, B.1.617.1,...
The cytokine interferon (IFN)-γ regulates immune clearance of parasitic, bacterial, and viral infections; however, the underlying mechanisms are poorly understood. Recently, a family IFN-γ–induced genes has been identified that encode 48-kD GTP-binding proteins localize to endoplasmic reticulum cells. prototype this family, IGTP, shown be required for host defense against acute infections with protozoan parasite Toxoplasma gondii, but not normal bacterium Listeria monocytogenes murine...
Abstract The roles that thymus cytokines might play in regulating thymic atrophy are not known. Reversing is important for immune reconstitution adults. We have studied cytokine mRNA steady-state levels 45 normal human (aged 3 days to 78 years) and 34 myasthenia gravis thymuses 4 75 during aging, correlated with signal joint (sj) TCR δ excision circle (TREC) levels, a molecular marker active thymopoiesis. LIF, oncostatin M (OSM), IL-6, M-CSF, stem cell factor (SCF) were elevated gravis-aged...
The perivascular space (PVS) of human thymus increases in volume during aging as thymopoiesis declines. Understanding the composition PVS is therefore vital to understanding mechanisms thymic atrophy. We have analyzed 87 normal and 31 myasthenia gravis (MG) tissues from patients ranging age newborn 78 years, using immunohistologic molecular assays. confirmed that although epithelial (TES) decreases progressively with age, active T-cell receptor gene rearrangement continued normally within...