A5102838679- Gut microbiota and health
- Liver Diseases and Immunity
- Inflammasome and immune disorders
- Effects of Radiation Exposure
- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- interferon and immune responses
- Pediatric Hepatobiliary Diseases and Treatments
- Viral Infections and Vectors
- IL-33, ST2, and ILC Pathways
- Viral gastroenteritis research and epidemiology
- Tryptophan and brain disorders
- RNA regulation and disease
- Ginseng Biological Effects and Applications
- Pancreatic and Hepatic Oncology Research
- Cancer survivorship and care
- Bacteriophages and microbial interactions
- Adipokines, Inflammation, and Metabolic Diseases
- Virus-based gene therapy research
University of North Carolina System
2022
University of North Carolina at Chapel Hill
2018-2021
AbbVie (Japan)
2021
AbbVie (United States)
2021
UNC Lineberger Comprehensive Cancer Center
2018
Stony Brook University
2012-2014
Ionizing radiation causes acute syndrome, which leads to hematopoietic, gastrointestinal, and cerebrovascular injuries. We investigated a population of mice that recovered from high-dose live normal life spans. These "elite-survivors" harbored distinct gut microbiota developed after protected against radiation-induced damage death in both germ-free conventionally housed recipients. Elevated abundances members the bacterial taxa
Objective Conflicting microbiota data exist for primary sclerosing cholangitis (PSC) and experimental models. Goal: define the function of complex resident microbes their association relevant to PSC patients by studying germ-free (GF) antibiotic-treated specific pathogen-free (SPF) multidrug-resistant 2 deficient ( mdr2 −/− ) mice microbial profiles in patient cohorts. Design We measured weights, liver enzymes, RNA expression, histological, immunohistochemical fibrotic biochemical...
Abstract Innate immunity to nucleic acids forms the backbone for anti-viral and several inflammatory diseases. Upon sensing cytosolic viral RNA, retinoic acid-inducible gene-I-like receptors (RLRs) interact with mitochondrial antiviral signaling protein (MAVS) activate TANK-binding kinase 1 (TBK1) induce type I interferon (IFN-I). TRAF3-interacting 3 (TRAF3IP3, T3JAM) is essential T B cell development. It also well-expressed by myeloid cells, where its role unknown. Here we report that...
Abstract Ionizing-radiation causes acute radiation syndrome leading to hematopoietic, gastrointestinal and cerebrovascular injuries. Substantial federal efforts have been made develop therapeutic radioprotectants for routine clinical use, however it remains a long-standing unresolved problem. We investigated population of mice that recovered from high-dose live normal lifespans. These elite-survivors harbored distinct gut microbiota developed post-radiation protected against...
Pancreatitis, a known risk factor for the development of pancreatic ductal adenocarcinoma, is serious, widespread medical condition usually caused by alcohol abuse or gallstone-mediated obstruction. However, many cases pancreatitis are an unknown etiology. Pancreatitis has been linked to bacterial infection, but causality yet be established. Here, we found that persistent infection mice with pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium) was sufficient induce reminiscent...
Abstract Objective Conflicting microbiota data exist for primary sclerosing cholangitis (PSC) and experimental models. Goal: Define complex interactions between resident microbes their association in PSC patients by studying antibiotic-treated specific pathogen-free (SPF) germ-free (GF) multi-drug-resistant 2 deficient ( mdr2 -/- ) mice. Design We measured weights, liver enzymes, RNA expression, histological, immunohistochemical fibrotic biochemical parameters, fecal 16s rRNA gene profiling,...
Abstract Platelet activating factor (PAF) is a biologically active phospholipid that promotes pathophysiological inflammation through binding to unique G-protein-coupled seven transmembrane receptor (PAFR). Increased PAF level has been correlated with number of inflammatory disorders, yet the molecular mechanism underlying pro-inflammatory function remains incompletely elucidated. Here we showed activates canonical NLRP3 inflammasome, resulting in ASC oligomerization, caspase-1 processing,...