A5001152735- Milk Quality and Mastitis in Dairy Cows
- Microbial infections and disease research
- Genetic and phenotypic traits in livestock
- Animal Disease Management and Epidemiology
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Animal Genetics and Reproduction
- Probiotics and Fermented Foods
- Effects of Environmental Stressors on Livestock
- Agriculture and Rural Development Research
- Animal Behavior and Welfare Studies
- Vector-Borne Animal Diseases
- Immune Response and Inflammation
- Reproductive Physiology in Livestock
- Virus-based gene therapy research
- Mycobacterium research and diagnosis
- Prion Diseases and Protein Misfolding
- Cytokine Signaling Pathways and Interactions
- Viral Infections and Vectors
- IL-33, ST2, and ILC Pathways
- Herpesvirus Infections and Treatments
- Infant Nutrition and Health
- Animal Diversity and Health Studies
- Ruminant Nutrition and Digestive Physiology
Interaction Hôtes Agents Pathogènes
2016-2025
École Nationale Vétérinaire de Toulouse
2014-2025
Université de Toulouse
2014-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2004-2025
Institut National Polytechnique de Toulouse
2009-2023
The Ohio State University
2016
Institut National de la Recherche Agronomique
2009-2015
Université Toulouse III - Paul Sabatier
1998-2013
Hôpital Rangueil
2013
National Institutes of Health
2002-2011
Differentiation of naïve CD4 T cells into helper (Th) 2 requires signaling through the cell receptor and an appropriate cytokine environment. IL-4 is critical for such Th2 differentiation. We show that IL-2 plays a central role in this process. The effect on generation does not depend its growth or survival effects. Stat5a -/- diminished differentiation to production, forced expression constitutively active form replaces need IL-2. In vivo neutralization inhibits production two models....
It is widely accepted that females have superior immune responses than males, but the ways by which sex hormones may enhance T cell are still poorly understood. In present study, we analyzed effect of estrogens on CD4 activation and differentiation after immunization with exogenous antigens. We show administration low doses 17beta-estradiol (E2) to castrated female mice results in a striking increase antigen-specific selective development IFN-gamma-producing cells. Quantitative assessment...
Abstract Mastitis caused by Escherichia coli and Staphylococcus aureus is a major pathology of dairy cows. To better understand the differential response mammary gland to these two pathogens, we stimulated bovine epithelial cells (bMEC) with either E. crude lipopolysaccharide (LPS) or S. culture supernatant (SaS) compare transcriptomic profiles initial bMEC response. By using HEK 293 reporter for pattern recognition receptors, LPS preparation was found stimulate TLR2 TLR4 but not TLR5, Nod1...
Mastitis is an infectious disease mainly caused by bacteria invading the mammary gland. Genetic control of susceptibility to mastitis has been widely evidenced in dairy ruminants, but genetic basis and underlying mechanisms are still largely unknown. We describe discovery, fine mapping functional characterization a variant associated with elevated milk leukocytes count, or SCC, as proxy for mastitis. After implementing genome-wide association studies, we identified major QTL SCC on ovine...
The need to integrate more clearly societal expectations on livestock farming has led the authors of this article consider that systems must be redesigned position health and welfare at heart their objectives. This proposes a vision advances in knowledge required different scales contribute transformation. After defining animals, emphasizes broader perspective, deepen question positive emotional experiences regarding welfare, raises how assess these two elements farms. interactions between...
T cell numbers are maintained within narrow ranges in vivo . Introduction of naïve cells into lymphopenic environments results proliferation and differentiation driven by the recognition peptide/MHC complexes cytokine signaling. This process, often described as homeostatic proliferation, is here referred to spontaneous proliferation. We show that, although presence memory CD4 broad repertoire efficiently inhibits proliferation/differentiation cells, a population similar size comprised with...
Abstract Current vaccines to Escherichia coli mastitis have shown some albeit limited efficacy. Their mode of action has not been documented, and immune responses protecting the mammary gland against E. are completely understood. To improve our knowledge protection, cows immunized either intramuscularly or intramammarily with P4 were submitted a homologous challenge. A third group mock-immunized serve as challenge controls. Local immunization modified favorably course infection, by improving...
Mononuclear phagocytes are organized in a complex system of ontogenetically and functionally distinct subsets, that has been best described mouse to some extent human. Identification homologous mononuclear phagocyte subsets other vertebrate species biomedical, economic, environmental interest is needed improve our knowledge physiologic physio-pathologic processes, design intervention strategies against variety diseases, including zoonotic infections. We developed streamlined approach...
Impaired type I interferons (IFNs) production or signaling have been associated with severe COVID-19, further promoting the evaluation of recombinant IFNs as therapeutics against SARS-CoV-2 infection. In Syrian hamster model, we show that intranasal administration IFN-α starting one day pre-infection post-infection limited weight loss and decreased viral lung titers. By contrast, at onset symptoms three days had no impact on clinical course Our results provide evidence early IFN treatment is...
Abstract Background The existence of a genetic basis for host responses to bacterial intramammary infections has been widely documented, but the underlying mechanisms and genes are still largely unknown. Previously, two divergent lines sheep selected high/low milk somatic cell scores have shown be respectively susceptible resistant by Staphylococcus spp . Transcriptional profiling with an 15K ovine-specific microarray cells infected successively S. epidermidis aureus was performed in order...
β-Glucans (BGs) are glucose polymers present in the fungal cell wall (CW) and, as such, recognized by innate immune cells microbial-associated pattern through Dectin-1 receptor. Recent studies have highlighted ability of pathogenic yeast Candida albicans or its CW-derived β(1,3) (1,6)-glucans to increase human monocytes cytokine secretion upon secondary stimulation, a phenomenon now referred training. This programming confers BGs an undeniable immunotherapeutic potential. Our objective was...
β-glucans (BG) are abundant polysaccharides of the Saccharomyces cerevisiae cell wall (Sc CW), an industry byproduct. They have immuno-stimulatory properties upon engagement dectin-1 (Clec7a), their main receptor on particular immune cells, and they actually become great interest because preventive or therapeutic potentials. Zymosan, a crude extract Sc CW was studied as prototypic BG, despite its miscellaneous PAMPs content. Here, we examined response murine wild type Clec7a-/- bone...