Ann E. Slingerland
A5087098201- Gut microbiota and health
- Neutropenia and Cancer Infections
- Clostridium difficile and Clostridium perfringens research
- Hematopoietic Stem Cell Transplantation
- Mycobacterium research and diagnosis
- Salivary Gland Disorders and Functions
- Oral health in cancer treatment
- Ginseng Biological Effects and Applications
- Clinical Nutrition and Gastroenterology
- Microscopic Colitis
- Pancreatic and Hepatic Oncology Research
- Renal Transplantation Outcomes and Treatments
- Dermatology and Skin Diseases
- Palliative Care and End-of-Life Issues
- Silymarin and Mushroom Poisoning
- Nutritional Studies and Diet
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Systemic Sclerosis and Related Diseases
- Liver Diseases and Immunity
- Pancreatic function and diabetes
- Infant Nutrition and Health
- CAR-T cell therapy research
- Natural product bioactivities and synthesis
- Cytomegalovirus and herpesvirus research
- Cancer Immunotherapy and Biomarkers
Memorial Sloan Kettering Cancer Center
2016-2023
Kettering University
2019-2021
Cornell University
2018-2019
Relationships between microbiota composition and clinical outcomes after allogeneic hematopoietic-cell transplantation have been described in single-center studies. Geographic variations the of human microbial communities differences practices across institutions raise question whether these associations are generalizable.
Treating neutropenic fever with broad-spectrum antibiotics after allogeneic hematopoietic stem cell transplant is associated an increase in graft-versus-host disease mice and humans.
Purpose The major causes of mortality after allogeneic hematopoietic-cell transplantation (allo-HCT) are relapse, graft-versus-host disease (GVHD), and infection. We have reported previously that alterations in the intestinal flora associated with GVHD, bacteremia, reduced overall survival allo-HCT. Because bacteria potent modulators systemic immune responses, including antitumor effects, we hypothesized components could be relapse Methods microbiota 541 patients admitted for allo-HCT was...
Disruption of intestinal microbial communities appears to underlie many human illnesses, but the mechanisms that promote this dysbiosis and its adverse consequences are poorly understood. In patients who received allogeneic hematopoietic cell transplantation (allo-HCT), we describe a high incidence enterococcal expansion, which was associated with graft-versus-host disease (GVHD) mortality. We found
Graft-versus-host disease (GVHD) in the gastrointestinal (GI) tract remains major cause of morbidity and nonrelapse mortality after BM transplantation (BMT). The Paneth cell protein regenerating islet-derived 3α (REG3α) is a biomarker specific for GI GVHD. REG3α serum levels rose systematic circulation as GVHD progressively destroyed cells reduced epithelial barrier function. Paradoxically, suppressed intestinal REG3γ (the mouse homolog human REG3α), absence BMT recipients intensified but...
Abstract Patients with multiple myeloma (MM) who achieve minimal residual disease (MRD) negativity after upfront treatment have superior outcomes compared those remain MRD+. Recently, associations been shown between specific commensal microbes and development of plasma cell disorders. Here, we report the association intestinal microbiota composition outcome in MM. Microbiota fecal samples collected from 34 MM patients induction therapy at time flow cytometry–based bone marrow MRD testing was...
Background Dysgeusia is a common but understudied complication in patients undergoing autologous hematopoietic cell transplantation (auto‐HCT). We assessed the feasibility of using chemical gustometry (CG) to measure dysgeusia and explored its associations with symptom burden, nutrition, chemotherapy pharmacokinetics (PK), oral microbiome. Methods conducted single‐center, prospective study (NCT03276481) multiple myeloma auto‐HCT. CG was performed longitudinally testing five flavors (sweet,...
Cellular therapy with chimeric antigen receptor (CAR) T cells has fundamentally changed the treatment of many cancers. Unfortunately, not all patients who receive this have a favorable response. Additionally, may develop toxicity due to cytokine release syndrome (CRS) or neurotoxicity. We hypothesized that composition intestinal microbiota prior CAR cell infusion is correlated efficacy and toxicity.We collected fecal samples from recipients at Memorial Sloan Kettering Cancer Center (MSKCC)...
Bacground: Increasing evidence suggests that the patientsÕ gut microbiota plays an important role in development of acute GVHD. Enterococcus faecium dominates microflora a substantial portion allo-HCT patients after transplant, and this domination can precede blood stream infections. Its relevance for GVHD, however, is poorly defined. Methods & Results: Extending our previously published observation (Taur et al., Clin Infect Dis 2012), we observed posttransplant monodomination microbiome...
Bone-marrow transplantation (BMT) offers curative potential for patients with high-risk hematologic malignancies. However, the post-transplantation period is characterized by immunodeficiency and delayed immune reconstitution an important contributor to transplant-related morbidity mortality (Maury et al., Br J Haematol, 2001; Small Blood, 1999). Recent studies indicate that intestinal microbiota not only regulates mucosal immunity, but can also contribute systemic immunity hematopoiesis...
Intestinal microbiota composition is associated with important outcomes after allo-HCT including survival, relapse, GVHD, and infections. Loss of diversity domination by single organisms common. Low poor overall survival from transplant-related mortality, death GVHD. These observations were all made in single-center cohorts. Here we compare—for the first time—the kinetics allo-HSCT patients (pts) three independent international institutions. We also explore role nutrition as well antibiotics...