A5037738786- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Hematopoietic Stem Cell Transplantation
- IL-33, ST2, and ILC Pathways
- Adipokines, Inflammation, and Metabolic Diseases
- vaccines and immunoinformatics approaches
- Pancreatic and Hepatic Oncology Research
- Tuberculosis Research and Epidemiology
- Diet and metabolism studies
- Listeria monocytogenes in Food Safety
- Liver Diseases and Immunity
- Probiotics and Fermented Foods
- Genomics, phytochemicals, and oxidative stress
- CAR-T cell therapy research
- Clinical Nutrition and Gastroenterology
- Thermoregulation and physiological responses
- Pediatric health and respiratory diseases
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Liver physiology and pathology
- Immune responses and vaccinations
- Gut microbiota and health
- Cancer Cells and Metastasis
- Heat shock proteins research
University of Michigan–Ann Arbor
2015-2019
Leiden University Medical Center
2006-2013
Hamamatsu University School of Medicine
2002
Kyungpook National University
1999
Graft-versus-host disease (GVHD) in the gastrointestinal (GI) tract remains major cause of morbidity and nonrelapse mortality after BM transplantation (BMT). The Paneth cell protein regenerating islet-derived 3α (REG3α) is a biomarker specific for GI GVHD. REG3α serum levels rose systematic circulation as GVHD progressively destroyed cells reduced epithelial barrier function. Paradoxically, suppressed intestinal REG3γ (the mouse homolog human REG3α), absence BMT recipients intensified but...
Abstract Obesity is a major health problem and known to be closely associated with metabolic diseases. Abnormal hepatic accumulation of fat causes fatty liver or steatosis, long-term consumption high-fat diet key obesity-causing factor. Recent studies have demonstrated that probiotics such as Lactobacillus strains , exert an anti-obesity effect by regulating adipogenesis. However, it still unknown how the can reduce abdominal volume expression lipogenic genes. Therefore, we evaluated...
The effect of minor H antigen mismatching on the occurrence graft-versus-host disease (GvHD) and graft-versus-leukemia (GvL) after HLA-matched hematopoietic stem cell transplantation (HSCT) has mainly been demonstrated in single-center studies. Yet, International Histocompatibility Immunogenetics Workshops (IHIW) provide a collaborative platform to execute crucial large In collaboration with 20 laboratories IHIW, roles 10 autosomal Y chromosome-encoded antigens were investigated GvHD relapse...
We report here the induction of specific protective cellular immunity against Mycobacterium tuberculosis by employment vaccination with recombinant attenuated Listeria monocytogenes strains. constructed self-destructing L. Delta 2 strains carrying eukaryotic expression plasmids for antigen 85 complex (Ag85A and Ag85B) MPB/MPT51 (mycobacterial protein secreted M. bovis BCG/mycobacterial tuberculosis) molecules. Infection these bacteria allowed genes in J774A.1 murine macrophage cell line....
Abstract Reactive oxygen species (ROS) are byproducts of aerobic metabolism and contribute to both physiological pathological conditions as second messengers. ROS essential for activation T cells, but how influence NKT cells is unknown. In the present study, we investigated role in cell function. We found that not CD4 or CD8 have dramatically high spleen liver mice thymus adipose tissues. Accordingly, ROS-high exhibited increased susceptibility apoptotic death with oxidative stress. High...
The gut microbiota is the most important environmental factor that plays a role in inducing obesity. gram-negative bacteria, Enterobacter cloacae strains, recently identified obese mice are considered to be pathogenic bacteria gut. Probiotics members of and exert beneficial effects, including inhibiting growth potential bacteria. Therefore, we isolated total 230 lactic acid from traditional, Korean fermented foods fecal samples newborn infants, Lactobacillus plantarum LMT1-48, which...
Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) proteins work in concert to regulate the levels of reactive oxygen species (ROS). The Keap1-Nrf2 antioxidant system also participates T cell differentiation inflammation, but its role innate development functions remains unclear. We report that cell-specific deletion Keap1 results defective reduced numbers invariant natural killer (NKT) cells thymus peripheral organs a cell-intrinsic manner....
HY-specific T cells are presumed to play a role in acute graft-versus-host disease (aGVHD) after female-to-male stem cell transplantation (SCT). However, infiltrates of these aGVHD-affected tissues have not yet been reported. We evaluated the application HLA-A2/HY dextramers for situ detection cryopreserved skin biopsy specimens. applied on specimens from seven male HLA-A2(+) pediatric patients who underwent with confirmed aGVHD involving skin. The demonstrated presence cells. In three...
Invariant Natural Killer T (iNKT) cells have been implicated in lung inflammation humans and also shown to be a key cell type inducing allergic mouse models. iNKT differentiate acquire functional characteristics during development the thymus. However, correlation between of thymus role remains unknown. In addition, transcriptional control differentiation into effector subsets is unclear. this report we show that β-catenin dependent mechanisms direct iNKT2 iNKT17 but not iNKT1 cells. To study...
ABSTRACT Listeria epitope-specific helper T (Th) cells were able to be primed and induced in vivo by immunization with a plasmid carrying an invariant chain (Ii) gene whose class II-associated peptide (CLIP) region was replaced Th epitope. Immunization of C3H/He mice Ii-LLO 215-226 specific interferon-γ- interleukin 2-producing conferred significant protective immunity against listerial infection.
T cells specific for hematopoietic system restricted minor Histocompatibility (H) antigens target normal and malignant cells. Thus, cellular immune responses against the latter miHAS eradicate recipient's hematopoiesis including residual leukemic after HLA-matched H antigen-mismatched stem-cell transplantation (SCT). However, there are controversial reports on role of HA-1 in development graft-versus-host-disease (GVHD) as well. Here, we address behavior HA-1-specific cytotoxic (CTLs) an ex...
Abstract Reactive oxygen species (ROS) are byproducts of aerobic metabolism and contribute to both physiological pathological conditions as second messengers. ROS essential for antigen specific activation T cells, but little is known about what role play in NKT cells. In the current study, we investigated cell function. We found that levels similar among CD4, CD8 subsets thymus. However, neither CD4 nor showed dramatically increased spleen liver not adipose tissues. peripheral cells were...
Regenerating islet-derived 3 (Reg3γ), a Paneth cell antimicrobial peptide, is an important biomarker of GI GVHD (Ferrara, Blood, 2012) but its mechanistic role in not known. cells decrease during severe both clinical and experimental BMT, therefore we evaluated whether the loss Reg3γ would amplify severity. IL-22, principle inducer Reg3γ, decreased prior to (data shown) injections IL-22 reversed ongoing two models (Figure 1A,B). We next compared wild type (WT) Reg3γ−/− recipients observed...
Abstract Cellular metabolism controlled by the signaling pathways has a crucial role in dictating outcome of T cell activation and effector function. Reactive oxygen species (ROS) are byproducts aerobic contribute to both physiological pathological conditions as second messenger. In cells, ROS levels increase upon antigen specific responses cells compromised absence production mitochondria. However, it is not well understood how NKT cells’ functions metabolism. current study, we investigated...