A5091649949- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Neuroscience and Neural Engineering
- Meningioma and schwannoma management
- Advanced MRI Techniques and Applications
- Intracranial Aneurysms: Treatment and Complications
- Pain Mechanisms and Treatments
- Vascular Malformations Diagnosis and Treatment
- Obsessive-Compulsive Spectrum Disorders
- Brain Metastases and Treatment
- Trigeminal Neuralgia and Treatments
- Biochemical and Structural Characterization
- EEG and Brain-Computer Interfaces
- Transcranial Magnetic Stimulation Studies
- Neurosurgical Procedures and Complications
- Glioma Diagnosis and Treatment
- Ultrasound and Hyperthermia Applications
- Facial Nerve Paralysis Treatment and Research
- Parkinson's Disease Mechanisms and Treatments
- Neurofibromatosis and Schwannoma Cases
- Glaucoma and retinal disorders
- Cardiac Arrest and Resuscitation
- Toxin Mechanisms and Immunotoxins
- Traumatic Brain Injury and Neurovascular Disturbances
- Head and Neck Surgical Oncology
Yonsei University
2016-2025
Severance Hospital
2014-2024
Nune Eye Hospital
2023
Sun Moon University
1970-2022
University of Toronto
2022
Toronto Western Hospital
2022
University Health Network
2022
Uijeongbu St. Mary's Hospital
2018-2021
Catholic University of Korea
2018-2021
Chonnam National University Hospital
2013-2020
<h3>Background</h3> Several options exist for surgical management of essential tremor (ET), including radiofrequency lesioning, deep brain stimulation and γ knife radiosurgery the ventralis intermedius nucleus thalamus. Recently, magnetic resonance-guided focused ultrasound (MRgFUS) has been developed as a less-invasive tool aimed to precisely generate focal thermal lesions in brain. <h3>Methods</h3> Patients underwent evaluation neuroimaging study at baseline up 6 months after MRgFUS....
Current soft neural probes are still operated by bulky, rigid electronics mounted to a body, which deteriorate the integrity of device biological systems and restrict free behavior subject. We report soft, conformable interface system that can monitor single-unit activities neurons with long-term stability. The implements in brain, their subsidiary directly printed on cranial surface. high-resolution printing liquid metals forms cellular-scale diameter adaptable lengths. Also, metal-based...
Magnetic resonance-guided focused ultrasound surgery (MRgFUS) was recently introduced as treatment for movement disorders such essential tremor and advanced Parkinson's disease (PD). Although deep brain target lesions are successfully generated in most patients, the area temperature fails to increase some cases. The skull is one of greatest barriers ultrasonic energy transmission. authors analyzed skull-related factors that may have prevented an temperatures patients who underwent MRgFUS.The...
Recently, a new thermal lesioning approach using magnetic resonance-guided focused ultrasound (MRgFUS) was introduced for the treatment of neurologic disorders. However, only 2 studies have used this treatment-refractory obsessive-compulsive disorder (OCD), and follow-up short-term. We investigated efficacy safety bilateral anterior limb internal capsule MRgFUS in patients with OCD followed them years.Eleven were included study. Clinical outcomes evaluated Yale-Brown Obsessive Compulsive...
Abstract Obesity is a major health problem and known to be closely associated with metabolic diseases. Abnormal hepatic accumulation of fat causes fatty liver or steatosis, long-term consumption high-fat diet key obesity-causing factor. Recent studies have demonstrated that probiotics such as Lactobacillus strains , exert an anti-obesity effect by regulating adipogenesis. However, it still unknown how the can reduce abdominal volume expression lipogenic genes. Therefore, we evaluated...
<i>Objective:</i> To investigate the long-term efficacy and adverse cognitive effects of stereotactic bilateral anterior cingulotomy as a treatment for refractory obsessive-compulsive disorder (OCD) patients. <i>Materials Methods:</i> Seventeen patients suffering from OCD underwent cingulotomies were followed 24 months. The Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), Clinical Global Impression other neuropsychological tests used to assess changes cingulotomy....
Unilateral pallidotomy has been accepted as an efficacious treatment for Parkinson disease (PD) compared with medical therapies.1 Currently, magnetic resonance–guided focused ultrasound (MRgFUS) developed a minimally invasive surgical technique, generating precise thermal lesions in the brain.2,3 We report successful unilateral MRgFUS patient PD to control not only levodopa-induced dyskinesia but also cardinal motor symptoms. Acknowledgment: Itay Rachmilevitch and Eyal Zadicario, employees...
The authors report different MRI patterns in patients with essential tremor (ET) or obsessive-compulsive disorder (OCD) after transcranial MR-guided focused ultrasound (MRgFUS) and discuss possible causes of occasional MRgFUS failure.Between March 2012 August 2013, was used to perform unilateral thalamotomy 11 ET bilateral anterior limb capsulotomy 6 OCD patients; all symptoms were refractory drug therapy. Sequential MR images obtained across a 6-month follow-up period.For patients, lesion...
Deep brain stimulation is an established treatment for movement disorders such as Parkinson's disease, essential tremor, and dystonia. However, various complications that occur after deep are a major concern patients neurosurgeons.This study aimed to analyze stimulation.We reviewed the medical records of with disorder who underwent bilateral between 2000 2020. Among them, requiring revision surgery were analyzed.A total 426 disorder. The primary disease was in 315 patients, followed by...
Conventional power-integrated wireless neural recording devices suffer from bulky, rigid batteries in head-mounted configurations, hindering the precise interpretation of subject's natural behaviors. These power sources also pose risks material leakage and overheating. We present direct printing a system that seamlessly conforms to cranium. A quasi-solid-state Zn-ion microbattery was 3D-printed as built-in source geometrically synchronized shape mouse skull. Soft deep-brain probes,...
Two arms to hold: Inspired by the structure of basic leucine-zipper proteins, high-affinity peptides, named aptides, were designed that contain a stabilizing scaffold (tryptophan zipper) and two target-binding regions (orange blue in picture). A fluorescently labeled aptide binds tumor-specific protein was used for fluorescence imaging vivo. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset....
<b><i>Background:</i></b> Treatment options for patients with drug-resistant essential tremor (ET) are limited. Magnetic resonance-guided focused ultrasound surgery (MRgFUS) is an emerging technique to treat refractory ET. <b><i>Objectives:</i></b> To present MRgFUS as alternative radiofrequency (RF) thalamotomy or deep brain stimulation (DBS) ET treatment. <b><i>Methods:</i></b> We retrospectively analyzed 59 who...
Obsessive-compulsive disorder is a debilitating and often refractory psychiatric disorder. Magnetic resonance-guided focused ultrasound novel, minimally invasive neuromodulatory technique that has shown promise in treating this condition. We investigated the relationship between lesion location long-term outcome patients with obsessive-compulsive treated to discern optimal elucidate efficacious network underlying symptom alleviation. Postoperative images of 11 who underwent capsulotomy were...
Integrating tactile feedback through haptic interfaces enhances experiences in virtual and augmented reality. However, electrotactile systems, which stimulate mechanoreceptors directly, often yield inconsistent results due to variations pressure between the device finger. In this study, we present integration of a transparent screen with pressure-sensitive transistors, ensuring highly consistent quantitative sensations. These transistors effectively calibrate caused by touch pressure....
Cervical transforaminal epidural steroid injection (TFESI) is a common treatment for cervical radiculopathy but carries potential risks because of the presence crucial arteries in intervertebral foramina (IVF). This study analyzed precise anatomical location segmental spinal artery (SSA) within IVF using 3D micro-CT imaging to provide guidance safer TFESI procedures. Fourteen embalmed cadavers were used this study: three serial sectional dissection, two histological examination, and nine...
Stimulating large volumes of neural networks using macroelectrodes can modulate disorder-associated brain circuits effectively. However, conventional solid-metal electrodes often cause unwanted damage due to their high mechanical stiffness. In contrast, low-modulus liquid metals provide tissue-like stiffness while maintaining macroscale electrode dimensions. Here, we present implantable soft made from biocompatible for stimulation. These probes be easily fabricated by simply filling...
This retrospective study aims to analyze hemorrhage complications in patients undergoing deep brain stimulation (DBS) surgery, focusing on the impact of imaging modalities and trajectory planning. We conducted a review who underwent DBS at single institution from September 2018 February 2023. Surgical planning data were analyzed using combination 1.5 Tesla(T) 3.0 T Magnetic resonance image (MRI) for Trajectories classified into four types (Type 1-4) based proximity vascular structures within...
OBJECT Neuropathic pain is often severe. Motor cortex stimulation (MCS) used for alleviating neuropathic pain, but the mechanism of action still unclear. This study aimed to understand MCS by investigating pain-signaling pathways, with expectation that would regulate both descending and ascending pathways. METHODS was induced in Sprague-Dawley rats. Surface electrodes were implanted Tactile allodynia measured behavioral testing determine effect MCS. For pathway study, immunohistochemistry...
Deep brain stimulation (DBS) targeting the ventralis intermedius (VIM) nucleus of thalamus and posterior subthalamic area (PSA) has been shown to be an effective treatment for essential tremor (ET). The aim this study was compare stimulation-induced side effects DBS VIM PSA using a single electrode. Patients with medication-refractory ET who underwent electrode implantation between July 2011 October 2020 surgical technique that simultaneously targets were enrolled in study. A total 93...
Deep brain stimulation is a treatment option for patients with drug-resistant epilepsy. The precise mechanism of neuromodulation in epilepsy unknown, and biomarkers are needed optimizing treatment. aim this study was to describe the neural network associated deep targets explore its potential application as novel biomarker neuromodulation. Using seed-to-voxel functional connectivity maps, weighted by seizure outcomes, areas were identified normative resting state scans 1000 individuals. To...