Since the use of magnetic nanocrystals as probes for biomedical system is attractive, it important to develop optimal synthetic protocols high-quality and have systematic understanding their nanoscale properties. Here we present development a synthetically controlled nanocrystal model that correlates tunabilities in terms size, magnetism, induced nuclear spin relaxation processes. This further led high-performance nanocrystal−antibody probe systems diagnosis breast cancer cells via resonance imaging.

The unique properties of magnetic nanocrystals provide them with high potential as key probes and vectors in the next generation biomedical applications. Although superparamagnetic iron oxide have been extensively studied excellent resonance imaging (MRI) for various cell trafficking, gene expression, cancer diagnosis, further development vivo MRI applications has very limited. Here, we describe diagnosis cancer, utilizing a well-defined nanocrystal probe system multiple capabilities, such...

Current biomedical imaging techniques including magnetic resonance (MRI), positron emission tomography (PET), and computed X-ray (CT) are vital in the diagnosis of various diseases. Each modality has its own merits disadvantages, a single technique does not possess all required capabilities for comprehensive imaging. Therefore, multimodal methods quickly becoming important tools state-of-the-art research clinical diagnostics therapeutics. In this Account, we will discuss synergistically...

Mesoporous silica nanoparticles are useful nanomaterials that have demonstrated the ability to contain and release cargos with mediation by gatekeepers. Magnetic nanocrystals exhibit hyperthermic effects when placed in an oscillating magnetic field. In a system combining these two materials thermally sensitive gatekeeper, unique drug delivery can be produced. A novel material incorporates zinc-doped iron oxide within mesoporous framework has been surface-modified pseudorotaxanes is...

Abstract The systematic shape control of colloidal nanocrystals including one‐dimensional (1D) nanorods remains a key issue in the “bottom–up” approach nanoscience. Here, we examine anisotropic structural evolution various semiconductor and systematically elucidate growth parameters for their control. crystalline phase nucleating seeds kinetic regimes controlled by changing are crucial determination 1D nanocrystal geometry.

Doped up: The incorporation of Zn(2+) dopants in tetrahedral sites leads to the successful magnetism tuning spinel metal ferrite nanoparticles (see picture). (Zn(0.4)Mn(0.6))Fe(2)O(4) exhibit highest magnetization value among nanoparticles. Such high results largest MRI contrast effects (r2=860 mm(-1) s(-1)) reported date and also huge hyperthermic effects.

The surfactant-mediated shape evolution of titanium dioxide anatase nanocrystals in nonaqueous media was studied. evolves from bullet and diamond structures to rods branched rods. modulation surface energies the different crystallographic faces through use a selective surfactant is key parameter for control.

The preparation of 2D layered SnS2 nanoplates with nanoscale lateral confinement (less than 150 nm) is described (see figure). Their unique characteristics, including finite morphology, make the discharge capacity Li ion batteries remarkably high-almost close to theoretical possible value.

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTControlled Synthesis of Multi-armed CdS Nanorod Architectures Using Monosurfactant SystemYoung-wook Jun, Sang-Min Lee, Nam-Jung Kang, and Jinwoo CheonView Author Information Department Chemistry School Molecular Science BK21, Korea Advanced Institute Technology (KAIST), Taejon 305-701, Cite this: J. Am. Chem. Soc. 2001, 123, 21, 5150–5151Publication Date (Web):May 8, 2001Publication History Received5 March 2001Revised16 April 2001Published...

We demonstrate a novel synthetic scheme that can be used to differentially guide the shape of PbS semiconductor nanocrystals. Our study first demonstrates discovery single-crystalline star-shaped nanocrystals as transient species. then carefully probe their evolution toward other nanostructures (e.g., tadpole-, L-, T-, cross-shapes, highly faceted star shapes, truncated octahedrons and cubes, etc.) systematically elucidate key parameters control these final structures. In principle, through...

With the aim of controlling nanoscale magnetism, we demonstrate an approach encompassing concepts surface and exchange anisotropy while reflecting size, shape, structural hybridization nanoparticles. We visualize that cube has higher magnetization value than sphere with highest coercivity at 60 nm. Its into core-shell (CS) structure brings about a 14-fold increase in exceptional energy conversion magnetic field thermal 10600 W/g, largest reported to date. Such capability CS-cube is highly...

Shape- and dopant-controlled magnetic semiconductor nanocrystals have been achieved by the thermolysis of nonpyrophoric less reactive single molecular precursors under a monosurfactant system. Reaction parameters governing both intrinsic crystalline phase growth regime (kinetic vs thermodynamic) are found to be important for synthesis various shapes MnS that include cubes, spheres, 1-dimensional (1-D) monowires, branched wires (bipods, tripods, tetrapods). Obtained nanowires exhibit enhanced...

Abstract Cancer‐cell‐targeted gene silencing was observed with a magnetic‐nanoparticle platform (MEIO, magnetism‐engineered iron oxide) on which fluorescent dye, siRNA, and RGD‐peptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance) microscopic (fluorescence) imaging of target cells. This system may be suitable for concurrent diagnostic therapeutic applications. magnified image

Working together: A "core–satellite" hybrid nanoparticle probe provides highly improved fluorescence and magnetic resonance (MR) imaging capabilities through synergistic enhancement of its respective components. These nanoprobes can be used for dual-modal MR neuroblastoma with expressed polysialic acids. Supporting information this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z603052_s.pdf or from author. Please note: The publisher not responsible...

Hybrid nanoparticles are of significant interest primarily because their innate multifunctional capabilities. These capabilities can be exploited when hybrid used for applications in the biomedical sciences particular, where they utilized as multimodal nanoplatforms sensing, imaging, and therapy biological targets. However, realization has been difficult, part a lack high quality which possess aqueous colloidal stability biocompatibility while retaining multifunctionalities. Here, we present...

Roll model: A new "shape-transformation" concept (see picture) that proceeds through a rolling out of 1D tungsten oxide nanorods for the fabrication laterally confined 2D WS2 nanosheet crystals has been developed. The resulting show significantly enhanced discharge capacity applications in lithium ion batteries owing to their nanoscale characteristics. Supporting information this article is available on WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z703175_s.pdf or from author....

Achieving high accuracy in the imaging of biological targets is a challenging issue. For MRI, to enhance accuracy, two different modes with specific contrast agents are used; one T1 type for "positive" MRI signal and other T2 "negative" signal. Conventional respond only single mode frequently encounter ambiguities MR images. Here, we propose "magnetically decoupled" core−shell design concept develop dual nanoparticle agent (DMCA). This DMCA not possesses superior effects but also has unique...