A5100319630- Nanoparticle-Based Drug Delivery
- Click Chemistry and Applications
- Advanced biosensing and bioanalysis techniques
- Advanced Polymer Synthesis and Characterization
- Electrochemical Analysis and Applications
- Quantum Dots Synthesis And Properties
- RNA Interference and Gene Delivery
- Polymer Surface Interaction Studies
- Gold and Silver Nanoparticles Synthesis and Applications
- Dendrimers and Hyperbranched Polymers
- Advancements in Solid Oxide Fuel Cells
- Surface Modification and Superhydrophobicity
- Monoclonal and Polyclonal Antibodies Research
- Chalcogenide Semiconductor Thin Films
- Catalytic Processes in Materials Science
- Adhesion, Friction, and Surface Interactions
- Electrochemical sensors and biosensors
- Nanomaterials for catalytic reactions
- Catalysis and Oxidation Reactions
- 3D Printing in Biomedical Research
- Additive Manufacturing and 3D Printing Technologies
- Virus-based gene therapy research
- Glycosylation and Glycoproteins Research
- Conducting polymers and applications
- Biosensors and Analytical Detection
Catholic University of Korea
2013-2025
Seoul National University of Science and Technology
2022-2024
Sungkyunkwan University
2024
Yeungnam University
2024
Hanyang University
2020-2023
Anyang University
2021
Seoul National University
2020
LG (South Korea)
2019
Wonkwang University
2009-2017
Konkuk University
2012-2017
We demonstrate a novel synthetic scheme that can be used to differentially guide the shape of PbS semiconductor nanocrystals. Our study first demonstrates discovery single-crystalline star-shaped nanocrystals as transient species. then carefully probe their evolution toward other nanostructures (e.g., tadpole-, L-, T-, cross-shapes, highly faceted star shapes, truncated octahedrons and cubes, etc.) systematically elucidate key parameters control these final structures. In principle, through...
Shape- and size-controlled synthesis of single-crystalline maghemite (gamma-Fe2O3) nanocrystals are performed by utilizing a solution-based one-step thermolysis method. Modulating the growth parameters, such as type amount capping ligands well time, is shown to have significant effect on overall shape size obtained ripening process itself. The resulting shapes novel structures diverse, including slightly faceted spheres, diamonds, prisms, hexagons, all which in fact truncated dodecahedron...
Polymer-incorporated liposomes were prepared from preformed and a cholesterol-functionalized poly(acrylic acid) additive via simple drop-in procedure. These modified possess surface-active carboxylate groups that can be cross-linked with telechelic 2,2'-(ethylenedioxy)bis(ethylamine) linkers, resulting in polymer-caged (PCLs) are highly stable have tunable pH-sensitive responses.
Multicomponent chemotherapy has increasingly become a strategy of great importance in clinical cancer treatments. However, this type not been demonstrated nanoscale delivery vehicles where two cytotoxic agents can be packaged together, potentially leading to synergistic drug activities. Herein, we present the codelivery doxorubicin and cisplatin via single polymer-caged nanobin (PCN) show that copackaging yield strong synergy efficacy these agents. Such PCN comprises doxorubicin-encapsulated...
Since the 1960s, stimuli-responsive polymers have been utilized as functional soft materials for biological applications such triggered-release delivery of biologically active cargos. Over same period, liposomes explored an alternative drug system with potentials to decrease toxic side effects often associated conventional small-molecule drugs. However, lack drug-release triggers and instability bare limit their practical applications, causing short circulation time low therapeutic efficacy....
Recently, metabolic glycoengineering with bioorthogonal click reactions has focused on improving the tumor targeting efficiency of nanoparticles as delivery vehicles for anticancer drugs or imaging agents. It is key technique developing tumor-specific precursors that can generate unnatural glycans tumor-cell surface. A cathepsin B-specific cleavable substrate (KGRR) conjugated triacetylated N-azidoacetyl-d-mannosamine (RR-S-Ac3 ManNAz) was developed to enable cells contain azide groups. The...
We demonstrate a novel synthetic scheme that can be used to control the crystalline phase and shape of GaP semiconductor nanocrystals. Our study shows steric effects surfactant ligands modulate phases shapes The nanocrystals obtained varies from zero-dimensional spheres one-dimensional rods via controlling ratio between primary tertiary alkylamines. III-V semiconductors (in our case: GaP) under 10 nm in width are first reported, unique optical properties due anisotropy also observed.
Modularly clickable polymer-caged nanobins (PCNs) were prepared from liposome templates using a drop-in cholesterol-modified poly(acrylic acid) reagent followed by cross-linking with alkyne-functionalized diamine linker that allows for the conjugation of azide-modified targeting ligands via click ligation. These PCNs possess pH-responsive characteristics can be used to trigger release encapsulated doxorubicin (DXR) payload inside liposomal core under mild acidic conditions. After...
Imaging techniques including computed tomography, magnetic resonance imaging, and positron emission tomography (PET) offer many potential benefits to diagnosis treatment of cancers. Each method has its own strong weak points. Therefore, multimodal imaging have been highlighted as an alternative for overcoming the limitations each respective method. In this study, we fabricated PET/optical activatable probe based on glycol chitosan nanoparticles (CNPs) imaging. To prepare dual probes CNPs,...
Cell labeling and tracking are important processes in understanding biologic mechanisms the therapeutic effect of inoculated cells vivo.Numerous attempts have been made to label track vivo; however, these methods limitations as a result their biological effects, including secondary phagocytosis macrophages genetic modification.Here, we investigated new cell strategy based on metabolic glycoengineering bioorthogonal click chemistry.We first treated with tetra-acetylated...
Establishment of an appropriate cell labeling and tracking method is essential for the development cell-based therapeutic strategies. Here, we are introducing a new by combining metabolic gylcoengineering bioorthogonal copper-free Click chemistry. First, chondrocytes were treated with tetraacetylated N-azidoacetyl-d-mannosamine (Ac4ManNAz) to generate unnatural azide groups (-N3) on surface cells. Subsequently, specifically conjugated near-infrared fluorescent (NIRF) dye-tagged dibenzyl...
Collisions of electrocatalytic platinum (Pt) single nanoparticles (NPs) with a less nickel (Ni) ultramicroelectrode (UME) surface were detected by amplification the current electrocatalysis NPs. Two typical types responses, staircase or blip (or spike), in NP collision experiments observed at time new system consisting Pt NP/Ni UME/hydrazine oxidation. The response was obtained when collided NPs attached to electrode and continued produce current. On other hand, believed be but deactivated....
Nanoscale drug delivery platforms can provide an attractive therapeutic strategy for cancer treatments, as they substantially reduce the adverse side effects associated with toxic small-molecule anticancer agents. For enhanced efficacy to be achieved such platforms, a tumor-specific drug-release trigger is critical requirement. This article reports use of pH-sensitive polymer network that surrounds nanoscale liposome core release both encapsulated hydrophilic, membrane-impermeable NiII...
Abstract Controlling multiscale structural heterogeneities in halide perovskites (HPs) is a key bottleneck to achieving the reproducible high‐performances and longevity of perovskite solar cells (PSCs). A correlative understanding chemical features at HP/charge transport layer interface vital realizing homogeneous monolithic crystal matrices. Yet, this not fully resolved as it requires holistic investigations multilayer systems. Herein, intricate correlations interfacial are by utilizing...
Engineered nanomaterials, with their tunable size and surface characteristics, have played a pivotal role in biomedical delivery systems by modulating specific cellular processes such as autophagy apoptosis, thereby influencing homeostasis cytotoxicity. Recently, zwitterionic poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) has gained attention for its enhanced biocompatibility antifouling properties, presenting potential promising alternative to poly(ethylene glycol) (PEG) various...
Encapsulation of chemotherapeutic agents inside a nanoscale delivery platform can provide an attractive therapeutic strategy with many pharmaceutical benefits, such as increased plasma solubility, prolonged in vivo circulation, and reduced acute toxicity. Given that the biological activities polymeric nanoparticles are highly dependent on their colloidal structures, molecular geometry-regulated programming self-assembled architecture is great interest for chemical design ideal platform. In...
Superhydrophobic surfaces have been fabricated for many biological and engineering applications. However, due to the delamination of nanostructured layer from a handling during fabrication process, we could not obtained uniform in large areas. Here, first report tens centimeter-scale superhydrophobic nanostructures with flexibility, cost-effective, no aging degradation drag reduction by adopting curing processes, which on size 30 × 14 cm2. Such nanostructure be potential platform...