A5075482161- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Child Nutrition and Feeding Issues
- Dysphagia Assessment and Management
- Nutrition and Health in Aging
- Virus-based gene therapy research
- RNA and protein synthesis mechanisms
- Immunotherapy and Immune Responses
- Advanced Nanomaterials in Catalysis
- Monoclonal and Polyclonal Antibodies Research
- Nutrition, Health and Food Behavior
- Toxin Mechanisms and Immunotoxins
- Graphene and Nanomaterials Applications
- Cultural Competency in Health Care
- Nanoplatforms for cancer theranostics
- Dementia and Cognitive Impairment Research
- Nanoparticles: synthesis and applications
- Advancements in Transdermal Drug Delivery
- Geriatric Care and Nursing Homes
- Healthcare Education and Workforce Issues
- Bacteriophages and microbial interactions
- Extracellular vesicles in disease
- Viral Infections and Immunology Research
- Characterization and Applications of Magnetic Nanoparticles
University of Iowa
2021-2025
Gyeongsang National University
2020-2024
Dongduk Women's University
2023
Sun Moon University
2022
Ewha Womans University
2016-2021
Ewha Womans University Medical Center
2019
Seoul Institute
2019
Government of the Republic of Korea
2019
Kumamoto University
2019
Sungkyunkwan University
2011-2018
Abstract Cancer‐cell‐targeted gene silencing was observed with a magnetic‐nanoparticle platform (MEIO, magnetism‐engineered iron oxide) on which fluorescent dye, siRNA, and RGD‐peptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance) microscopic (fluorescence) imaging of target cells. This system may be suitable for concurrent diagnostic therapeutic applications. magnified image
Abstract Lipid nanoparticles (LNPs) exhibit remarkable mRNA delivery efficiency, yet their majority accumulate in the liver or spleen after injection. Tissue‐specific can be achieved through modulating LNP properties, such as tuning PEGylation varying lipid components systematically. In this paper, a streamlined method is used for incorporating tumor‐targeting peptides into LNPs; programmed death ligand 1 (PD‐L1) binding are conjugated to PEGylated lipids via copper‐free click reaction, and...
Chemical conjugates of paclitaxel and hyaluronic acid (HA) were synthesized by utilizing a novel HA solubilization method in single organic phase. Hydrophilic was completely dissolved anhydrous DMSO with addition poly(ethylene glycol) (PEG) forming nanocomplexes. Paclitaxel then chemically conjugated to the phase via an ester linkage without modifying extremely hydrophilic HA. A series HA−paclitaxel different conjugation percentages characterized. self-assembled aqueous solution form...
Abstract Gold nanoprobes immobilized with fluorescein‐hyaluronic acid (HA) conjugates are fabricated and utilized for monitoring intracellular reactive oxygen species (ROS) generation in live cells via nanoparticle surface energy transfer. A bio‐inspired adhesive molecule, dopamine, is used to robustly end‐immobilize HA onto the of gold nanoparticles (AuNPs) securing stability against glutathione. ROS induces cleavage fragmentation chains on AuNPs allows rapid specific detection by emitting...
Starch-coated, PEGylated, and heparin-functionalized iron oxide magnetic nanoparticles (DNPH) were successfully synthesized characterized in detail. The PEGylation (20 kDa) process resulted an average coating of 430 PEG molecules per nanoparticle. After that, heparin conjugation was carried out to attain the final DNPH platform with 35.4 μg heparin/mg Fe. Commercially acquired heparin-coated also PEGylated (HP) for comparison. Protamine selected as a model protein demonstrate strong binding...
For mRNA mediated cancer immunotherapy, Pam3 was incorporated as an adjuvant within lipid nanoparticles (LNPs) with OVA mRNA.
Abstract Eine gezielte Genstummschaltung in Krebszellen gelang mit magnetischen Eisenoxid‐Nanopartikeln (MEIO), an denen ein Fluoreszenzfarbstoff, siRNA sowie RGD‐Peptid zur Erkennung von angebracht waren (siehe Bild). Die verschiedenen funktionellen Einheiten ermöglichen eine kombinierte makroskopische (Kernspin‐) und mikroskopische (Fluoreszenz‐)Tomographie der Zielzellen. Dieses System könnte sich für die parallele diagnostische therapeutische Anwendung eignen. magnified image
Pluronic/polyethylenimine shell crosslinked nanocapsules with embedded magnetite nanocrystals (PPMCs) were developed for magnetically triggered delivery of siRNA. The positively charged PPMCs formed stable nanosized polyelectrolyte complexes via electrostatic interactions negatively siRNA-polyethylene glycol conjugate (siRNA-s-s-PEG) that was linked a cleavable disulfide linkage. PPMC/siRNA-s-s-PEG efficiently taken up by cancer cells upon exposure to magnet, thereby enhancing intracellular...
Trail polymerization enables a significant enhancement of the DhITACT system. DhITACT-Trail (DNA hydrogel formation by isothermal amplification complementary targets trail polymerization) offers robust diagnosis target RNA strands in pseudo-serum specimen. This system requires minimum liquid handling as compared to conventional analysis. In addition, definitive diagnostic result can be achieved within 30 min an optical detection. As service our authors and readers, this journal provides...