A5000604839- Polymer Surface Interaction Studies
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Hydrogels: synthesis, properties, applications
- RNA Interference and Gene Delivery
- Molecular Junctions and Nanostructures
- Surface Modification and Superhydrophobicity
- Advanced Sensor and Energy Harvesting Materials
- Advanced biosensing and bioanalysis techniques
- Hemostasis and retained surgical items
- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- Conducting polymers and applications
- biodegradable polymer synthesis and properties
- Silk-based biomaterials and applications
- Nanoplatforms for cancer theranostics
- Surgical Sutures and Adhesives
- Virus-based gene therapy research
- Nanofabrication and Lithography Techniques
- Adhesion, Friction, and Surface Interactions
- Nanoparticle-Based Drug Delivery
- Marine Biology and Environmental Chemistry
- Advanced Drug Delivery Systems
- Dendrimers and Hyperbranched Polymers
- Force Microscopy Techniques and Applications
Korea Advanced Institute of Science and Technology
2016-2025
Daejeon University
2014-2020
Kootenay Association for Science & Technology
2017-2020
Government of the Republic of Korea
2015-2019
Yonsei University
2010-2015
Center for NanoScience
2010-2014
Korea National University of Transportation
2014
Pohang University of Science and Technology
2013
Institute for Basic Science
2013
Seoul National University
2013
We report a method to form multifunctional polymer coatings through simple dip-coating of objects in an aqueous solution dopamine. Inspired by the composition adhesive proteins mussels, we used dopamine self-polymerization thin, surface-adherent polydopamine films onto wide range inorganic and organic materials, including noble metals, oxides, polymers, semiconductors, ceramics. Secondary reactions can be create variety ad-layers, self-assembled monolayers deposition long-chain molecular...
The glue proteins secreted by marine mussels bind strongly to virtually all inorganic and organic surfaces in aqueous environments which most adhesives function poorly. Studies of these functionally unique have revealed the presence unusual amino acid 3,4-dihydroxy- l -phenylalanine (dopa), is formed posttranslational modification tyrosine. However, detailed binding mechanisms dopa remain unknown, chemical basis for mussels’ ability adhere both has never been fully explained. Herein, we...
Polydopamine is one of the simplest and most versatile approaches to functionalizing material surfaces, having been inspired by adhesive nature catechols amines in mussel proteins. Since its first report 2007, a decade studies on polydopamine molecular structure, deposition conditions, physicochemical properties have ensued. During this time, potential uses coatings expanded many unforeseen directions, seemingly only limited creativity researchers seeking simple solutions manipulating...
A new surface bioconjugation strategy is presented. polydopamine coating provides chemical activation on material surfaces, resistant to hydrolysis, and offers selectivity in coupling of biomolecules via nucleophilic groups through simple pH control. Control orientation immobilized may be possible using terminally modified DNA or His-containing proteins. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited...
Abstract Polydopamine is the first adhesive polymer that can functionalize surfaces made of virtually all material chemistries. The material‐independent surface modification properties polydopamine allow functionalization various types medical and energy devices. However, mechanism dopamine polymerization has not yet been clearly demonstrated. Covalent oxidative via 5,6‐dihydroxyindole (DHI), which similar to for synthetic melanin synthesis, clue. Here, it reported a physical, self‐assembled...
Abstract Bone tissue is a complex biocomposite material with variety of organic (e.g., proteins, cells) and inorganic hydroxyapatite crystals) components hierarchically organized nano/microscale precision. Based on the understanding such hierarchical organization bone its unique mechanical properties, efforts are being made to mimic these organic–inorganic hybrid biocomposites. A key factor for successful designing complex, biomaterials facilitation control adhesion at interfaces, as many...
Bioinspired from adhesion behaviors of mussels, injectable and thermosensitive chitosan/Pluronic composite hydrogels were synthesized for tissue adhesives hemostatic materials. Chitosan conjugated with multiple catechol groups in the backbone was cross-linked terminally thiolated Pluronic F-127 triblock copolymer to produce temperature-sensitive adhesive sol–gel transition hydrogels. A blend mixture catechol-conjugated chitosan a viscous solution state at room temperature but became gel...
Conjugation of mussel-inspired catechol groups to various polymer backbones results in materials suitable as silicon anode binders. The unique wetness-resistant adhesion provided by the allows nanoparticle electrodes maintain their structure throughout repeated volume expansion and shrinkage during lithiation cycling, thus facilitating substantially improved specific capacities cycle lives lithium-ion batteries.
Abstract Surface modification is one of the most important techniques in modern science and engineering. The facile introduction a wide variety desired properties onto virtually any material surface an ultimate goal chemistry. To achieve this goal, incorporation structurally diverse molecules essential capability for ideal modification. Here, general strategy presented which many surfaces can be functionalized by immobilizing molecules. This functionalizes one‐step immersion substrates...
A new method for creating layer-by-layer (LbL) assembled films on any substrate using polymers inspired by the high catechol content of mussel adhesive proteinsis presented. Catechol-derivatized permit LbL assembly challenging substrates without prior surface preparation. Catechol groups incorporated into film induce reduction silver ions to metallic when immersedin an aqueous metal salt solution, providing antibacterial properties.
Abstract This study presents a method of simultaneous reduction and surface functionalization graphene oxide by one‐step poly(norepinephrine) functionalization. The pH‐induced aqueous poly(norepinephrine), catecholamine polymer inspired the robust adhesion marine mussels, chemically reduced functionalized oxide. Moreover, polymerized norepinephrine (pNor) layer provided multifunctionality on that includes surface‐initiated polymerization spontaneous metallic nanoparticle formation. facile...
Science MIMIC-king nature: Hydrophilic conversion of superhydrophobic surfaces can be easily achieved through a bioinspired approach to produce an alternating superhydrophobic–hydrophilic surface by using established soft-lithographic techniques, such as micromolding in capillaries (MIMIC). The resulting patterned showed high water adhesion properties well properties. Detailed facts importance specialist readers are published ”Supporting Information”. Such documents peer-reviewed, but not...
The individual encapsulation of living cells has a great impact on the area cell-based sensors and devices as well fundamental studies in cell biology. In this work, yeast were individually encapsulated with functionalizable, artificial polydopamine shells, inspired by an adhesive protein mussels. Yeast maintained their viability within polydopamine, cycle was controlled thickness shells. addition, shells aided offering much stronger resistance against foreign aggression, such lyticase....
Current hyaluronic acid (HA) hydrogel systems often cause cytotoxicity to encapsulated cells and lack the adhesive property required for effective localization of transplanted in vivo. In addition, injection into certain organs (e.g., liver, heart) induces tissue damage hemorrhage. this study, we describe a bioinspired, tissue‐adhesive that overcomes limitations current HA hydrogels through its improved biocompatibility potential minimally invasive cell transplantation. functionalized with...
Hyaluronic acid (HA) hydrogels are widely pursued as tissue regenerative and drug delivery materials due to their excellent biocompatibility biodegradability. Inspired by mussel adhesion, we report here a novel class of thermo-sensitive injectable HA/Pluronic F127 composite tissue-adhesive applicable for various biomedical applications. HA conjugated with dopamine (HA-DN) was mixed thiol end-capped Pluronic copolymer (Plu-SH) produce lightly cross-linked gel structure based on Michael-type...
Various methods have been developed in surface chemistry to control interface properties of a solid material. A selection rule among chemistries is compatibility between functionalization tool and target For example, alkanethiol deposition on noble metal surfaces, widely known as the formation self-assembled monolayer (SAM), cannot be performed oxide material surfaces. One must choose organosilane molecules functionalize Thus, strictly depends surface. Polydopamine coating now generally...
A facile approach for material-independent surface modification using norepinephrine was investigated. pH-induced oxidative polymerization of forms adherent films on vastly different types material surfaces noble metals, metal oxides, semiconductors, ceramics, shape-memory alloys, and synthetic polymers. Secondary biochemical functionalizations such as immobilization proteins growth biodegradable polyester the poly(norepinephrine) were demonstrated.
Hyaluronic-acid immobilized monodisperse magnetic nanocrystals (HA-DN/MNCs) are synthesized. Dopamine, the analogue of 3,4-dihydroxy-L-phenylalanine responsible for adhesion properties in proteins excreted by mussels, plays a key role surface modification nanocrystals. HA-DN/MNCs exhibit great stability aqueous solution, applicable vivo targeted-cancer imaging.
Aims: Polydopamine coating is emerging as a useful method of surface functionalization due to the ability this compound form nanometer-scale organic thin film on virtually any material which proteins, peptides, oligonucleotides, metal ions or synthetic polymers are able be attached. The unique properties polydopamine make technique suitable for nanomedicine. To facilitate use polydopamine, evaluation toxicity great importance. In article, we investigated in vivo polydopamine. Results: We...
Abstract Nature has developed materials that are integrated and effective at controlling their properties of adhesiveness cohesiveness; the chemistry these been optimized during evolution. For example, a catechol moiety found in adhesive proteins marine mussels regulates its between adhesion cohesion, rapidly adapting to environmental conditions. However, synthetic chemistry, introduced chemical moieties usually monofunctional, either being or cohesive; typically, this is not compared...