Photoluminescent graphene quantum dots (GQDs) have fascinating optical and electronic properties with numerous promising applications in biomedical engineering. In this work, we first studied the vivo biodistribution potential toxicity of carboxylated photoluminescent GQDs. KB, MDA-MB231, A549 cancer cells, MDCK normal cell line were chosen as vitro culture models to examine possible adverse effects The GQDs are desirable for increased aqueous solubility. All cells efficiently took up No...

Abstract Surface modification is one of the most important techniques in modern science and engineering. The facile introduction a wide variety desired properties onto virtually any material surface an ultimate goal chemistry. To achieve this goal, incorporation structurally diverse molecules essential capability for ideal modification. Here, general strategy presented which many surfaces can be functionalized by immobilizing molecules. This functionalizes one‐step immersion substrates...

Abstract This study presents a method of simultaneous reduction and surface functionalization graphene oxide by one‐step poly(norepinephrine) functionalization. The pH‐induced aqueous poly(norepinephrine), catecholamine polymer inspired the robust adhesion marine mussels, chemically reduced functionalized oxide. Moreover, polymerized norepinephrine (pNor) layer provided multifunctionality on that includes surface‐initiated polymerization spontaneous metallic nanoparticle formation. facile...

Aims: Polydopamine coating is emerging as a useful method of surface functionalization due to the ability this compound form nanometer-scale organic thin film on virtually any material which proteins, peptides, oligonucleotides, metal ions or synthetic polymers are able be attached. The unique properties polydopamine make technique suitable for nanomedicine. To facilitate use polydopamine, evaluation toxicity great importance. In article, we investigated in vivo polydopamine. Results: We...

Biological functions depend on biomolecular assembly processes. Assemblies of lipid bilayers, actins, microtubules, or chromosomes are indispensable for cellular functions. These hierarchical processes reasonably predictable by understanding chemical structures the defined building blocks and their interactions. However, biopigment is rather fuzzy unpredictable because a series covalently coupled intermediates from catecholamine oxidation pathways progressively form higher-level hierarchy....

This work demonstrates the way to achieve efficient and target specific delivery of a graphene quantum dot (GQD) using hyaluronic acid (HA) (GQD-HA) as targeting agent. HA has been anchored GQD that accepts fascinating adhesive properties catechol moiety, dopamine hydrochloride, conjugated HA, which was confirmed by X-ray photoelectron spectroscopy. Transmission electron microscopy revealed particle size ∼20 nm, fluorescence spectra significant intensity even after anchoring HA. The prepared...

We report on catechol-grafted poly(ethylene) glycol (PEG-g-catechol) for the preparation of nonfouling surfaces versatile substrates including adhesion-resistant PTFE. PEG-g-catechol was prepared by step-growth polymerization PEO to which dopamine, a mussel-derived adhesive molecule, conjugated. The immersion into an aqueous solution resulted in robust PEGylation noble metals, oxides, and synthetic polymers. Surface unambiguously confirmed various surface analytical tools such as...

Although the electronic properties of conducting films have been widely explored in optoelectronic fields, optical absorption abilities surface-coated for photothermal conversion relatively less production antibacterial coatings. Here, we present catechol-conjugated poly(vinylpyrrolidone) sulfobetaine (PVPS) and polyaniline (PANI) tightly linked by ionic interaction (PVPS:PANI) as a novel agent surface coating, which can absorb broadband near-infrared (NIR) light. Taking advantage NIR light...

Abstract Light‐induced wireless soft electronic skin hydrogels with excellent mechanical and properties are important for several applications, such as robotics intelligent wearable devices. Precise control of reversible stretchability capacitive depending on intermolecular interaction surface characteristics remains a challenge. Here, thin‐film hydrogel is designed based titanium oxide (TiO 2 ) polydopamine–perfluorosilica carbon dot‐conjugated chitosan–polyvinyl alcohol‐loaded tannic acid...

Recently, a great deal of research has focused on the study self-healing hydrogels possessing electronic conductivity due to their wide applicability for use in biosensors, bioelectronics, and energy storage. The low solubility, poor biocompatibility, lack effective stimuli-responsive properties sp2 carbon-rich hybrid organic polymers, however, have proven challenging electroconductive hydrogel fabrication. In this study, we developed electrochemical wireless biosensors using...

Water soluble fluorescent carbon nanoparticles (FCP) obtained from a single natural source, mango fruit, were developed as unique materials for non-toxic bio-imaging with different colors and particle sizes. The prepared FCPs showed blue (FCP-B), green (FCP-G) yellow (FCP-Y) fluorescence, derived by the controlled carbonization method. demonstrated hydrodynamic diameters of 5–15 nm, holding great promise clinical applications. biocompatible potential in biological fields through results...

Growing microbial resistance that renders antibiotic treatment vulnerable has emerged, attracting a great deal of interest in the need to develop alternative antimicrobial treatments. To contribute this effort, we report magnetic iron oxide (Fe3O4) nanoparticles (NPs) coated with catechol-conjugated poly(vinylpyrrolidone) sulfobetaines (C-PVPS). This negatively charged Fe3O4@C-PVPS is subsequently encapsulated by poly(3,4-ethylenedioxythiophene) (PEDOT) following layer-by-layer (LBL)...

The research and development of fluorescent carbon nanoparticles, from their resources, synthesis method to applications in theranostic sensing application have been attractive due unique properties.

Limited light absorption beyond the UV region and rapid photocarrier recombination are critical impediments for improved photocatalytic performance of carbon quantum dots (CQDs) under visible-light irradiation. Herein, we demonstrate single-step microwave-assisted syntheses O-CQDs (typical CQDs terminated by carboxylic hydroxyl functional groups) from a sucrose precursor Cl-doped (Cl-CQDs) sucralose in short reaction times without using obligatory strong acids Cl doping. The doping into is...

The direct use of conventional photosensitizers in photodynamic therapy (PDT) cancer cells has been thwarted by their low solubility, poor photostability, and aggregation tendency. Hence, complex hectic synthetic procedures, such as developing nanomaterials subsequently loading them with photosensitizers, have become mandatory for the effective PDT. In this study, we avoided procedures produce hematoporphyrin (HP) photosensitizer-encapsulated carbon quantum dots (CQDs) (HP-CQDs) facilely...

Abstract A cancer‐selective self‐reporting sensor based on a redox‐responsive mineralized conductive hydrogel (M‐Hydrogel) is proposed with cancer‐specific viscosity, adhesive strength, stretchability, tunable conductivity, and fluorescence. The redox‐triggered release of carbonized polydopamine (cPDA) from the loaded disulfide‐crosslinked polymer dots (PD@cPDA) in matrix modulates macroporous structure responsible for self‐recognizable cancer sensing photothermal activity therapy. nature...

Abstract Cancer cell‐triggered sol–gel transformation of mineralized hydrogel (PAA‐MnO 2 ) is designed as a facile strategy for cancer detection by manipulating the mineralization process in presence cells. The polyacrylic acid (PAA) with calcium phosphate via carboxyl‐Ca 2+ complex initially inhibited incorporation reactive oxygen species (ROS)‐sensitive manganese oxide (MnO polymer dots (PDs). In this system, can be induced after cleaving MnO into Mn high ROS levels cells, forming PAA‐MnO...

Gold nanoparticles were employed to prepare shell cross-linked Pluronic micelles that exhibit a reversibly thermosensitive swelling/shrinking behavior. Two terminal hydroxyl groups of F127 thiol-functionalized form self-assembling in aqueous solution with exposed −SH an outer layer. The thiol present the by gold synthesized through NaBH4 reduction precursor anions. resultant gold−Pluronic exhibited temperature-dependent volume transition: their hydrodynamic diameter was changed from 157.1 ±...

Extracellular matrix protein patterns are fabricated and utilized to identify the optimal insoluble (physical) cues, investigate effect of physical cues combined with cell–cell interactions on neuronal glial differentiation neural stem cells.

This present article demonstrates the strategy to prepare photoresponsive reduced graphene oxide with mussel inspired adhesive material dopamine (DN) and photochromic dye spiropyran (SP) conjugated backbone of targeting ligand hyaluronic acid (HA; HA-SP). Graphene (GO) was by prepared HA-SP accepting advantages catechol chemistry under mildly alkaline condition enabling achieve functionalized (rGO/HA-SP) as fluorescent nanoparticles. Due containing HA, rGO/HA-SP can bind CD44 cell receptors....

Strongly fluorescent carbon quantum dots (CQDs) were simply prepared by microwave-assisted synthesis using succinic acid and tris(2-aminoethyl)amine as an “A₂ + B₃” monomer set with a high mass yield of 17.3%.