A5069318434- Polymer Surface Interaction Studies
- Hydrogels: synthesis, properties, applications
- Electrospun Nanofibers in Biomedical Applications
- Hemostasis and retained surgical items
- Surgical Sutures and Adhesives
- 3D Printing in Biomedical Research
- Osteoarthritis Treatment and Mechanisms
- Advanced biosensing and bioanalysis techniques
- Carbon and Quantum Dots Applications
- Silk-based biomaterials and applications
- Conducting polymers and applications
- RNA Interference and Gene Delivery
- Advanced Sensor and Energy Harvesting Materials
- biodegradable polymer synthesis and properties
- Knee injuries and reconstruction techniques
- Tissue Engineering and Regenerative Medicine
- Advanced Nanomaterials in Catalysis
- Salivary Gland Disorders and Functions
- Peroxisome Proliferator-Activated Receptors
- Periodontal Regeneration and Treatments
- Advanced Drug Delivery Systems
- Fire dynamics and safety research
- Gold and Silver Nanoparticles Synthesis and Applications
- Blood properties and coagulation
- Agriculture, Soil, Plant Science
Wonkwang University
2018-2025
Convergence
2024
Yeouido St. Mary's Hospital
2020-2022
Catholic University of Korea
2020-2022
Duke University
2018-2021
University of California, San Diego
2017
Gyeongsang National University
2016
Korea Advanced Institute of Science and Technology
2011-2015
Armed Forces Capital Hospital
2015
Daejeon University
2014
Polydopamine is one of the simplest and most versatile approaches to functionalizing material surfaces, having been inspired by adhesive nature catechols amines in mussel proteins. Since its first report 2007, a decade studies on polydopamine molecular structure, deposition conditions, physicochemical properties have ensued. During this time, potential uses coatings expanded many unforeseen directions, seemingly only limited creativity researchers seeking simple solutions manipulating...
Bioinspired from adhesion behaviors of mussels, injectable and thermosensitive chitosan/Pluronic composite hydrogels were synthesized for tissue adhesives hemostatic materials. Chitosan conjugated with multiple catechol groups in the backbone was cross-linked terminally thiolated Pluronic F-127 triblock copolymer to produce temperature-sensitive adhesive sol–gel transition hydrogels. A blend mixture catechol-conjugated chitosan a viscous solution state at room temperature but became gel...
Conjugation of mussel-inspired catechol groups to various polymer backbones results in materials suitable as silicon anode binders. The unique wetness-resistant adhesion provided by the allows nanoparticle electrodes maintain their structure throughout repeated volume expansion and shrinkage during lithiation cycling, thus facilitating substantially improved specific capacities cycle lives lithium-ion batteries.
Current hyaluronic acid (HA) hydrogel systems often cause cytotoxicity to encapsulated cells and lack the adhesive property required for effective localization of transplanted in vivo. In addition, injection into certain organs (e.g., liver, heart) induces tissue damage hemorrhage. this study, we describe a bioinspired, tissue‐adhesive that overcomes limitations current HA hydrogels through its improved biocompatibility potential minimally invasive cell transplantation. functionalized with...
DNA has emerged as a novel material in many areas of materials science due to its programmability. Especially, hydrogels have been studied incorporate new functions into gels. To date, only few methods developed for fabricating hydrogels, such the use complementary sequences or covalent bond. Herein, it is demonstrated that one most well‐known plant‐derived polyphenols, tannic acid (TA), can form hydrogel which named TNA ( T A + D NA ). TA plays role “molecular glue” by mode action...
Magnetic nanoparticles have gained significant attention as a therapeutic agent for cancer treatment. Herein, we developed chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes (Chito-FIONs) an effective heat nanomediator hyperthermia. Dynamic light scattering and transmission electron microscopic analyses revealed that Chito-FIONs were composed of multiple 30-nm-sized FIONs encapsulated by polymer shell. Multiple in interior increased the total magnetic moments, which leads...
Adhesives play an important role in industrial fields such as electronics, architectures, energy plantation, and others. However, adhesives used for medical purpose are rather under‐developed compared with those industry consumer products. One key property required is to maintain their adhesiveness the presence of body fluid. Here, entirely new class called TAPE reported; this produced by intermolecular hydrogen bonding between a well‐known polyphenol compound, tannic acid, poly(ethylene...
Alginate hydrogels are for various biomedical applications including tissue engineering, cell therapy, and drug delivery. However, it is not easy to control swelling or viscoelastic biophysical properties of alginate prepared by conventional cross-linking methods (ionic interaction using divalent cations). In this study, we describe a bioinspired approach preparing ion-free that exhibit tunable physical mechanical improved biocompatibility due the absence cations in gel matrices. We...
For the increasing demand of soft materials with wide ranges applications, hydrogels have been developed exhibiting variety functions (e.g., stretchable, self-healing, stimuli-responsive, and etc.). So far, add-in components such as inorganic nanoparticles, carbon materials, clays, many others to main polymers used achieve various unique hydrogels. The multicomponent hydrogel systems often exhibit batch-dependent inconsistent results problems in mixings, require labors during preparations,...
Mussel-inspired adhesion chemistry provides a useful alternative to the use of fibrin glues.
This report describes a simple method to prepare water-soluble chitosan derivative by conjugation of an enediol group, catechol. Chitosan functionalized with catechol-containing compound, 3,4-dihydroxyhydrocinnamic acid, carbodiimide coupling resulted in chitosan-catechol conjugates. one-step chemical modification high-molecular-weight (approximately 100 kDa) dramatically increased the water solubility 60 mg mL-1 at pH 7.0. The degree catechol was found critical determining solubility....
Recently, a great deal of research has focused on the study self-healing hydrogels possessing electronic conductivity due to their wide applicability for use in biosensors, bioelectronics, and energy storage. The low solubility, poor biocompatibility, lack effective stimuli-responsive properties sp2 carbon-rich hybrid organic polymers, however, have proven challenging electroconductive hydrogel fabrication. In this study, we developed electrochemical wireless biosensors using...
Abstract Catechol, a unique adhesive molecule found in mussel proteins, can reduce metal ions while it is oxidized and polymerized with amines to polydopamine (pD). Here, pD coatings are employed simultaneous reduction of prepare electrospun polymer nanofibers functionalized nanoparticles. The oxidative polymerization dopamines mediates the silver metallic nanoparticles their deposition on nanofibers. formation silver‐pD‐coated stabilizes porous structure aqueous solution. It expected that...
Abstract The development of bioadhesives has become an emerging research field for tissue sealants, wound dressings, and hemostatic agents. However, assembling hydrogels using bioadhesive‐mediated attachment remains a challenging task. Significantly high water content (>90%) in compared to that biological tissues is the main cause failure. Considering are primary testing scaffolds mimicking vivo environments, developing strategies assemble exhibit diverse properties important....
Abstract Here, in Ppara −/− mice, we found that an increased DNL stimulated the cartilage degradation and identified ACOT12 as a key regulatory factor. Suppressed level of was observed cartilages OA patient OA-induced animal. To determine role association pathogenesis, generated Acot12 knockout (KO) ( ) mice using RNA-guided endonuclease. displayed severe with stimulation matrix MMPs chondrocyte apoptosis through accumulation acetyl CoA. Delivery CoA-conjugated chitosan complex into...
We report an effective and versatile approach to control marine fouling on artificial surfaces based specific chemical interactions found in mussels. The consists of mussel-inspired polydopamine coating, spin-coating-assisted deposition poly(ethylene glycol) (PEG) catechols, their cross-linking via catechol-Fe3+-catechol interactions. Using this approach, multilayered PEG films that were highly resistant diatom adhesion successfully constructed various substrates, such as stainless steel,...
A new Ca2+-alginate hydrogel with improved physical stability is prepared by covalent tethering of catechols. Ionic to bond transition spontaneously occurs in physiological conditions. It found that the kinetics leaching out Ca2+ ions from chelated carboxylates and oxidative intercatechol cross-linking similar, successfully maintaining original shapes without conventionally performed treatment cationic polymers on surface hydrogels.
Abstract The intraperitoneal (IP) cavity is the largest fluid‐filled space in body and contains important organs. Although peritoneal fluid from abdominal lubricates allows organ motion, this also effectively prevents polymeric material implantation. Anastomotic leakage after surgery has been reported but few sealing methods have developed. Herein, a fluid‐resistant adhesive called IP patch that seals intestinal neo‐anastomosis sites, preventing anastomotic colorectal surgery. bursting...
Introduction: Cartilage regeneration is a challenging issue due to poor regenerative properties of tissues. Electrospun nanofibers hold enormous potentials for treatments cartilage defects. However, nanofibrous materials used the treatment defects often require physical and/or chemical modifications promote adhesion, proliferation, and differentiation cells. Thus, it highly desirable improve their surface with functionality. We aim design hydrophilic, adhesive, compound K-loaded Methods:...
Novel metal nanostructures immobilized within three-dimensional (3D) porous polymeric scaffolds have been utilized for catalysts and biosensors. However, efficient, robust immobilization of the both outside inside 3D is a challenging task. To address challenge, we synthesized redox-active polymer, catechol-grafted poly(vinyl alcohol), PVA-g-ct. The grafted catechol inspired by adhesion mechanism marine mussels, which facilitates binding reduction noble ions. Electrospinning PVA-g-ct polymer...
In general, mechanical properties and gelation kinetics exhibit a positive correlation with the amount of reagents used. Similarly, for catechol-containing hydrogels, which have attracted significant attention, because their unique dual cohesion adhesion, increased amounts cross-linking agents, such as organic oxidants and/or transition metals (Fe3+), result in enhanced strength more rapid kinetics. Here, we report new metal–ligand chemistry, inspired by mussels ascidians, that defies...