A5007975077- Electrospun Nanofibers in Biomedical Applications
- Tracheal and airway disorders
- Tissue Engineering and Regenerative Medicine
- Dysphagia Assessment and Management
- Voice and Speech Disorders
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Wound Healing and Treatments
- Polymer Surface Interaction Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Nerve injury and regeneration
- Silk-based biomaterials and applications
- Vascular Anomalies and Treatments
- Pregnancy-related medical research
- Cardiac Structural Anomalies and Repair
- Trauma Management and Diagnosis
- Mesenchymal stem cell research
- Mechanical Circulatory Support Devices
- Preterm Birth and Chorioamnionitis
- Advanced Sensor and Energy Harvesting Materials
- Glaucoma and retinal disorders
- Surface Modification and Superhydrophobicity
- Ocular and Laser Science Research
- Laser Applications in Dentistry and Medicine
- Healthcare Policy and Management
Chonnam National University Hospital
2015-2024
Seoul National University
1999-2023
Seoul National University Bundang Hospital
2023
Seoul National University Hospital
2018-2022
Government of the Republic of Korea
2020
Biomedical Research Institute
2020
Johns Hopkins University
2018-2019
Johns Hopkins Medicine
2018-2019
Chonnam National University
2019
Health Insurance Review and Assessment Service
2016
Soft tissue losses from tumor removal, trauma, aging, and congenital malformation affect millions of people each year. Existing options for soft restoration have several drawbacks: Surgical such as the use autologous flaps lead to donor site defects, prosthetic implants are prone foreign body response leading fibrosis, fat grafting dermal fillers limited small-volume defects only provide transient volume restoration. In addition, large-volume other tissue-engineering attempts hampered by...
Abstract Decellularized tissues composed of extracellular matrix (ECM) have been clinically used to support the regeneration various human and organs. Most decellularized so far derived from animals or cadavers. Therefore, despite many advantages tissue, there are concerns about potential for immunogenicity possible presence infectious agents. Herein, we present a biomaterial ECM adipose most prevalent, expendable, safely harvested tissue in body. The was extracted by successive physical,...
Two different growth factors were physically and chemically loaded into a single nanofibrous matrix to increase wound healing efficacy obtain bi-phasic release profiles of the factors. Amine-functionalized block copolymers composed PCL PEG synthesized subsequently co-electrospun with bFGF solution prepare coaxial meshes. The meshes modified an EGF by conjugating surface-exposed amine groups nanofibers carboxylate EGF. characterization core-encapsulated surface-immobilized X-ray photoelectron...
Abstract For successful tracheal reconstruction, tissue-engineered artificial trachea should meet several requirements, such as biocompatible constructs comparable to natural trachea, coverage with ciliated respiratory mucosa, and adequate cartilage remodeling support a cylindrical structure. Here, we designed an mechanical properties similar the native that can enhance regeneration of mucosa through optimal combination two-layered tubular scaffold human induced pluripotent stem cell...
Abstract Wound‐adhesive and thermo‐responsive hydrogels were prepared in an aim to develop a wound‐care device for diabetic ulcers. A mixture of glycidyl methacrylated chitooligosaccharide (COS), di‐acrylated Pluronic, recombinant human epidermal growth factor (rhEGF) formed physical hydrogel. Photo‐irradiation was subsequently applied chemically crosslink the Release profiles encapsulated rhEGF from hydrogel showed that release rates dependent on degradation hydrogels. Human primary...
We designed bilayer composites composed of an upper layer titanium dioxide (TiO2)-incorporated chitosan membrane and a sub-layer human adipose-derived extracellular matrix (ECM) sheet as wound dressing for full-thickness healing. The dense fibrous top layer, which aims to protect the from bacterial infection, was prepared by electrospinning solution followed immersion in TiO2 solution. sponge-like sub-layer, promote new tissue regeneration, with acellular ECM derived adipose tissue. Using...
Adipose tissue is found over the whole body and easily obtained in large quantities with minimal risk by a common surgical operation, liposuction. Although liposuction was originally intended for removal of undesired adipose tissue, it may provide an ideal material engineering scaffolds. Here we present novel, porous scaffolds prepared from human tissues. The were fabricated variety macroscopic shapes such as round dishes, squares, hollow tubes, beads. microscopic inner structure controlled...
Abstract Due to a lack of proper drug carriers deliver treatments for mucositis, many cancer patients suffer from oral mucositis caused by chemotherapy and radiotherapy. We prepared double‐layered electrospun nanofibrous sheets composed Eudragit chitosan accelerate the healing rate mucous ulcer. Human growth hormone (hGH) in mixture dimethylacetamide ethanol were co‐electrospun sheets. The fibrous mat was subsequently layered with dip‐coating method. Chitosan‐layered showed attenuated mass...
Severe damage to the ocular surface can result in limbal stem cell (LSC) deficiency, which contributes loss of corneal clarity, potential vision loss, chronic pain, photophobia, and keratoplasty failure. Human amniotic membrane (AM) is most effective substrate for LSC transplantation treat patients with deficiency. However, widespread use AM clinic remains a challenge because high cost preserving freshly prepared weak mechanical strength lyophilized AM. Here, we developed novel composite...
Despite recent developments in the tracheal tissue engineering field, creation of a patient specific substitute possessing both appropriate mechanical and biointerfacial properties remains challenging.
Electrospun nanofiber surfaces are modified with proteins to control protein release. A mixture of poly(ε-caprolactone) (PCL) and PCL—PEG block copolymers is electrospun prepare amine-terminated copolymers. The amount surface exposed amine groups increases as the blend ratio copolymer increases. Cell attachments on nanofibers change according in blend; this indicates that PEG moiety plays a significant role enhancing decreasing biocompatibility nanofibers. Fluorescent immobilized by...
Monomeric catechols are displayed on the surface of polymeric nanofibers by robust catechol–thiol interactions to enhance cell adhesion and migration. Dihydroxyphenyl propionic acid is chemically conjugated primary amine groups poly(ϵ‐caprolactone)‐poly(ethylene glycol)‐amine (PCL‐PEG) display catechol moieties surface. At basic pH, catecholized incorporate thiol at a five‐fold higher rate than acidic while catechol‐coated surfaces do not show any pH‐dependent binding. Live/dead staining...
To investigate the efficacy of topical 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) in a mouse model experimental dry eye (EDE).Eye drops consisting 0.001% or 0.01% AICAR, 0.05% cyclosporine A (CsA), balanced salt solution (BSS) were applied for treatment EDE. Tear volume, tear film break-up time (BUT), and corneal fluorescein staining scores measured 10 days after treatment. Levels interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, gamma-induced...
Loss of voice after vocal fold resection due to laryngeal cancer is a significant problem resulting in low quality life. Although there were many attempts achieve functional restoration voice, challenges regenerate still remain its unique tissue mechanical characteristics such as pliability that produces phonation via vibration. In this study, we developed mechanically compliant interpenetrating polymer network (IPN) hydrogel based on polyacrylamide (PAAM) and gelatin matches physical...
While demand for cardiovascular surgery is expected to increase gradually along with the rapid in diseases respect aging population, supply of thoracic and surgeons has been continuously decreasing over past 10 years. Consequently, this study aims achieve guidance establishing health care policy by analyzing surgeries medical service area Korea.After investigating actual number performed using National Health Insurance claim data Review Assessment Service, as well drawing from national...
Purpose: To investigate the wound healing effect of adiponectin eye drops following corneal alkali burn.Materials and Methods: A chemical burn was induced using 0.1 M NaOH in both adenovirus 12-SV40 hybrid-transformed human epithelial (HCE-2) cells C57BL/6 mice. The injured HCE-2 mice were then treated either 0.1% hyaluronic acid (HA) or at 0.0001%, 0.001%, 0.01% concentration. viability measured 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. rate evaluated a migration...
Nanofibrous matrix was fabricated for the purpose of obtaining bi-phasic protein releases from a single delivery system. A block copolymer composed poly(ethylene glycol) and poly(epsilon-caprolactone) co-electrospun with solutions through dual nozzle electrospinning Surface-exposed amine groups protein-encapsulating nanofiber at an aqueous phase were chemically conjugated to carboxyl another surface-immobilization. The surface-immobilized proteins core-encapsulated in nanofibers...