A5101624319- Hematopoietic Stem Cell Transplantation
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Orthopedic Infections and Treatments
- Neonatal Respiratory Health Research
- Nutrition and Health in Aging
- Postharvest Quality and Shelf Life Management
- Bacterial biofilms and quorum sensing
- Transplantation: Methods and Outcomes
- RNA modifications and cancer
- Chemical Synthesis and Analysis
- Ocular Surface and Contact Lens
- Greenhouse Technology and Climate Control
- Nerve injury and regeneration
- Liver physiology and pathology
- Bone Tissue Engineering Materials
- Organophosphorus compounds synthesis
- Surgical site infection prevention
- Hydrogels: synthesis, properties, applications
- CAR-T cell therapy research
- Physical Activity and Health
- Polymer Surface Interaction Studies
- Immunotherapy and Immune Responses
- Obesity, Physical Activity, Diet
Nanjing Forestry University
2024
Jiangsu Cancer Hospital
2022
Nanjing Medical University
2022
Johns Hopkins University
2011-2019
Johns Hopkins Medicine
2011-2019
University of Manitoba
2004
Wuhan University
1995
Soft tissue losses from tumor removal, trauma, aging, and congenital malformation affect millions of people each year. Existing options for soft restoration have several drawbacks: Surgical such as the use autologous flaps lead to donor site defects, prosthetic implants are prone foreign body response leading fibrosis, fat grafting dermal fillers limited small-volume defects only provide transient volume restoration. In addition, large-volume other tissue-engineering attempts hampered by...
Bacterial biofilm formation is a major complication of implantable medical devices that results in therapeutically challenging chronic infections, especially cases involving antibiotic-resistant bacteria. As an approach to prevent these electrospun composite coating comprised poly(lactic-coglycolic acid) (PLGA) nanofibers embedded poly(ε-caprolactone) (PCL) film was developed locally codeliver combinatorial antibiotics from the implant surface. The release each antibiotic could be adjusted...
Abstract An efficient and practical ex vivo expansion methodology for human hematopoietic stem/progenitor cells (HSPCs) is critical in realizing the potential of HSPC transplantation treating a variety hematologic disorders as supportive therapy malignant diseases. We report here an strategy using three‐dimensional (3D) scaffold conjugated with extracellular matrix molecule, fibronectin (FN), to partially mimic stem cell niche. FN‐immobilized 3D polyethylene terephthalate (PET) was...
Insufficient numbers of hematopoietic stem cells (HSCs) and progenitor (HPCs) sometimes limit allogenic transplantation umbilical cord blood (UCB). Ex vivo expansion may overcome this limitation. Mesenchymal (MSCs), as non-hematopoietic, well-characterized skeletaland connective-tissue within the bone marrow stroma, have been investigated support for culture HSCs/HPCs. MSCs are attractive rich environmental signals that they provide immunological compatibility in transplantation. Thus far,...
Severe damage to the ocular surface can result in limbal stem cell (LSC) deficiency, which contributes loss of corneal clarity, potential vision loss, chronic pain, photophobia, and keratoplasty failure. Human amniotic membrane (AM) is most effective substrate for LSC transplantation treat patients with deficiency. However, widespread use AM clinic remains a challenge because high cost preserving freshly prepared weak mechanical strength lyophilized AM. Here, we developed novel composite...
Previous studies have shown that substrate surface chemistry and topography exhibit significant impact on haematopoietic progenitor cell adhesion, proliferation differentiation. In the present study, effect of amine density structure grafted polymer chains adhesion expansion cells was investigated. Cryopreserved human umbilical cord blood CD133 + were expanded in cytokine-supplemented medium ethylenediamine (EDA)- or 2-aminoethyl methacrylate hydrochloride (AEMA)-grafted polyethersulphone...
In vivo bioluminescence imaging (BLI) provides noninvasive monitoring of bacterial burden in animal models orthopaedic implant-associated infection (OIAI). However, technical limitations have limited its use to mouse and rat OIAI. The goal this study was develop a larger, rabbit model OIAI using BLI evaluate the efficacy an antibiotic-releasing implant coating.A nanofiber coating loaded with or without linezolid-rifampin electrospun onto surgical-grade locking peg. To rabbits, medial...
Vascular endothelial growth factor (VEGF) is a potent regulator for liver regeneration following partial hepatectomy. However, intravenous delivery of VEGF has yielded limited success in promoting the remnant liver. Here we report new approach to locally deliver recombinant from an electrospun poly-ε-caprolactone nanofiber mesh and its effect on improving rat after 70% After applying VEGF-releasing lobes hepatectomy rats, fractions proliferating hepatocytes increased markedly at 48 h 72...
Gastric cancer is one of the most common malignancies with high mortality worldwide. It known that long noncoding RNAs (lncRNAs) play important roles in pathogenesis gastric cancer. This study investigates role lncRNA ZNF667-AS1 cells.We have applied real-time quantitative PCR (qPCR) to levels biopsies and cell lines. The effects on propagation, clonogenicity, metastasis, angiogenesis cells were evaluated by calorimetry, colony formation, migration, assays. Western blotting was used identify...
This study investigated whether a behaviour change program, based on Canada's Physical Activity Guide and Handbook to Healthy Active Living for Older Adults (Health Canada, 1999a), would elicit greater benefits than adoption of the guide handbook alone. Fifteen older adults received accompanying completed 8-week program (mean age 73.2 +/- 5.2 yrs), while 14 others only 76.8 10.0 yrs). Functional fitness (lower body strength/endurance, flexibility, agility/dynamic balance) (Rikli Jones,...
Abstract The phosphorylating polycondensation in solution catalyzed by 4‐dimethylaminopyridine (DMAP) was studied for the first time. polymerization rate and average molecular weight of polyphosphate are increased using DMAP as a catalyst. influence reaction conditions on catalytic activity were preliminarily investigated.