A5027882975- Graphene and Nanomaterials Applications
- Essential Oils and Antimicrobial Activity
- Proteoglycans and glycosaminoglycans research
- Ethnobotanical and Medicinal Plants Studies
- Hydrogels: synthesis, properties, applications
- Advanced Polymer Synthesis and Characterization
- Nanoparticle-Based Drug Delivery
- Heparin-Induced Thrombocytopenia and Thrombosis
- Carbon and Quantum Dots Applications
- Nanoplatforms for cancer theranostics
- Venous Thromboembolism Diagnosis and Management
- Polymer Surface Interaction Studies
- Medicinal Plants and Neuroprotection
- Photochromic and Fluorescence Chemistry
- Pharmacological Effects of Natural Compounds
- Natural Antidiabetic Agents Studies
- Dendrimers and Hyperbranched Polymers
- Psidium guajava Extracts and Applications
- Virology and Viral Diseases
- Phytochemistry and biological activity of medicinal plants
- Atrial Fibrillation Management and Outcomes
- Polymer Nanocomposite Synthesis and Irradiation
- Natural product bioactivities and synthesis
- Polydiacetylene-based materials and applications
- Ginger and Zingiberaceae research
The University of Queensland
2018-2025
University of Development Alternative
2014
Korea National University of Transportation
2011-2013
This work demonstrates the way to achieve efficient and target specific delivery of a graphene quantum dot (GQD) using hyaluronic acid (HA) (GQD-HA) as targeting agent. HA has been anchored GQD that accepts fascinating adhesive properties catechol moiety, dopamine hydrochloride, conjugated HA, which was confirmed by X-ray photoelectron spectroscopy. Transmission electron microscopy revealed particle size ∼20 nm, fluorescence spectra significant intensity even after anchoring HA. The prepared...
This present article demonstrates the strategy to prepare photoresponsive reduced graphene oxide with mussel inspired adhesive material dopamine (DN) and photochromic dye spiropyran (SP) conjugated backbone of targeting ligand hyaluronic acid (HA; HA-SP). Graphene (GO) was by prepared HA-SP accepting advantages catechol chemistry under mildly alkaline condition enabling achieve functionalized (rGO/HA-SP) as fluorescent nanoparticles. Due containing HA, rGO/HA-SP can bind CD44 cell receptors....
Abstract Thiolated Pluronic (Plu‐SH) nanoparticles are developed as potential articulate, target‐specific anticancer‐drug carriers for intracellular drug release triggered by the difference in redox tumor cells. The cores of micelles formed disulfide bonds functionalized F127, when dissolved an aqueous solution. 95.6 ± 18.6 nm size, and 235.6 63.7 after encapsulation hydrophobic molecules. drug‐loaded show effective stability blood‐plasma conditions kinetics micelle shown. Paclitaxel‐loaded...
Abstract Thromboses are potentially fatal complication in malignant tumor diseases. Today, oral anticoagulants considered equivalent alternatives to low molecular weight heparin (LMWH) guideline‐based treatments of cancer‐associated thromboses. Nevertheless, debates on potential antitumorigenic activities beyond anticoagulation still highly relevant. However, disclosure targeted is complicated by the heterogeneous structure this glycosaminoglycan natural origin. Therefore, synthetic polymers...
Sanfilippo syndrome (Mucopolysaccharidosis type III, or MPS III) is an inherited neurodegenerative disorder resulting from mutations in genes encoding lysosomal enzymes that sequentially degrade heparan sulfate. Currently, there are no approved treatments and life expectancy <20 years. The two most common subtypes IIIA IIIB, caused by N-sulfoglucosamine sulfohydrolase (SGSH) α-N-acetylglucosaminidase (NAGLU), respectively. Fluorogenic substrates based on a 4-methylumbelliferyl aglycone...
Heparin, a sulfated polysaccharide derived from animal sources, is the most commonly used parenteral anticoagulant drug, but it suffers significant safety and supply issues. Herein, we describe preparation of heparin mimetic homo- copolymers via reversible addition–fragmentation chain transfer (RAFT) polymerization in water commercially available (non-carbohydrate) sulfonated carboxylated monomers. The activities polymers were assessed by activated partial thromboplastin time (APTT),...
Abstract Novel spiropyran‐conjugated Pluronic [polyethylene oxide (PEO)‐b‐polypropylene (PPO)‐b‐polyethylene (PEO)] micelles are developed as a new colorimetric detector showing photo‐ or thermo‐switchable behavior. Facile conjugation of spiropyran to was confirmed by 1 H NMR, UV–Vis, and Fluorescence spectroscopy. A switchable photoluminescence is found depending on the irradiation with either UV visible light, temperature resulting from structural isomerization between (SP) merocyanine...
This paper reports the construction of a novel multi-sensitive chemically crosslinked injectable hydrogel with strong mechanical strength by modifying Pluronic F127 responsive against temperature, pH and redox potential. Crosslinked polymer between benzaldehyde grafted (P-A) amine end capped having disulfide linkage (P-B) have been synthesized characterized 1H NMR spectroscopy GPC. The under physiological conditions significantly altered sol-gel transition behaviors much lower critical...
Low-molecular-weight heparin (LMWH) is the guideline-based drug for antithrombotic treatment of cancer patients, while its direct antitumor effects are a matter ongoing debate. Although therapeutically established decades, LMWH has several drawbacks mainly associated with origin from animal sources. Aiming to overcome these limitations, library synthetic mimetic polymers consisting homo- and copolymers sulfonated carboxylated noncarbohydrate monomers recently been synthesized via reversible...
Mosquito-borne viruses are a major worldwide health problem associated with high morbidity and mortality rates significant impacts on national healthcare budgets. The development of antiviral drugs for both the treatment prophylaxis these diseases is thus considerable importance. To address need therapeutics activity, library heparan sulfate mimetic polymers was screened against dengue virus (DENV), Yellow fever (YFV), Zika (ZIKV), Ross River (RRV). were prepared by RAFT polymerization...
Abstract pH and thermo‐responsive graft copolymers are reported where poly( N ‐isopropylacrylamide) [poly(NIPAAm), poly A ], ‐isopropylacrylamide‐ co ‐2‐(diethylamino) ethyl methacrylate) [poly(NIPAAm‐ ‐DEA), B ‐methacrylic acid) ‐MAA), C ] have been installed to benzaldehyde grafted polyethylene glycol (PEG) back bone following introducing a responsive benzoic‐imine bond. All the prepared for PEG‐ g ‐poly(NIPAAm) [ P‐N1 ‐poly(NIPAAm‐ ‐DEA) P‐N2 ‐MAA) P‐N3 were characterized by 1 H‐NMR...
Abstract The glycosaminoglycan heparin is a clinically important anticoagulant drug, primarily used to reduce the risk of blood clots (thrombosis) during surgery. Despite its importance in medicine and continuous use over many decades, suffers from several limitations associated with heterogeneity extraction animal tissues. In order address these limitations, reversible addition‐fragmentation chain transfer polymerization utilized prepare library mimetic copolymers sulfonated monomers sodium...
ABSTRACT Soluble chemically reduced graphene oxide (RGO)/poly(4‐vinyl pyridine) (P4VP) assembly was attempted by totally noncovalent approach. Chemical reduction of P4VP/GO mixture hydrazine produced soluble RGO/P4VP with long term stability. Prepared showed pH‐dependent variation optical transmittance. Transmittance solution at pH 2.0 dramatically increased more than 200% transmittance 6. This change fully reversible. The detailed morphological features assemble evaluated dynamic light...
Rheumatoid arthritis (RA) is an autoimmune disease characterized with a chronic, systemic inflammation which primarily affects synovial joints. A significant percentage of the world population including notably aged groups suffers from such disabling and painful condition that can result in substantial loss normal functioning mobility, if not adequately treated. Natural products have always been potential source alternative therapy lead compounds for various diseases. good number...