A5016589529- Blood Coagulation and Thrombosis Mechanisms
- Congenital Heart Disease Studies
- Venous Thromboembolism Diagnosis and Management
- Blood properties and coagulation
- Platelet Disorders and Treatments
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hemophilia Treatment and Research
- COVID-19 Clinical Research Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiac Arrest and Resuscitation
- Antiplatelet Therapy and Cardiovascular Diseases
- Dermatological and COVID-19 studies
- Inflammatory Biomarkers in Disease Prognosis
- Advanced Proteomics Techniques and Applications
- Infective Endocarditis Diagnosis and Management
- Cardiac and Coronary Surgery Techniques
- Cardiac Ischemia and Reperfusion
- Coronary Artery Anomalies
- Metabolism and Genetic Disorders
- Blood transfusion and management
- Infectious Aortic and Vascular Conditions
The University of Melbourne
2014-2025
Royal Children's Hospital
2012-2025
Murdoch Children's Research Institute
2015-2025
Pediatrics and Genetics
2024
Baker Heart and Diabetes Institute
2014
Background We sought to characterize body composition abnormalities in young patients living with a Fontan circulation and explore potential pathophysiologic associations. Methods Results Twenty-eight were prospectively recruited this cross-sectional study. Participants underwent cardiopulmonary exercise testing, dual-energy X-ray absorptiometry, echocardiography, biochemical assessment. Mean age was 26±7 years. Skeletal muscle mass, estimated by appendicular lean mass index Z score, reduced...
The most effective method of long-term thromboprophylaxis after the Fontan procedure is not clear. We compared rates thromboembolic events between patients receiving aspirin and warfarin an extracardiac conduit in a bi-national registry. All who underwent from 1997 to 2010 Australia New Zealand were identified. Medication status routine follow-up echocardiographic data obtained all patients. Survival analysis with propensity score matching adjustment was performed determine treatment effect...
Neurocognitive outcomes beyond childhood in people with a Fontan circulation are not well defined. This study aimed to investigate neurocognitive functioning adolescents and adults associations structural brain injury, volumetry, postnatal clinical factors.In binational study, participants without preexisting major neurological disability were prospectively recruited from the Australia New Zealand Registry. function was assessed by using Cogstate software 107 compared control groups...
Platelets are subcellular fragments which circulate in blood and have well established roles thrombosis haemostasis adults. Upon activation, platelets undergo granule exocytosis express P-Selectin on the cell membrane binds a ligand monocytes, leading to monocyte-platelet aggregation. Elevated circulating aggregates adults linked atherothrombosis, but not been investigated children where is less common. This study aimed measure aggregate formation using whole flow cytometry....
Abstract Only half of individuals with suspected rare diseases receive a definitive genetic diagnosis following genomic testing. A allows access to appropriate patient care and reduces the number potentially unnecessary interventions related healthcare costs. Here, we demonstrate that an untargeted quantitative mass-spectrometry approach quantifying >6,000 proteins in primary fibroblasts representing >80% known mitochondrial disease genes can provide functional evidence for 83% cohort...
Abstract Thromboses are potentially fatal complication in malignant tumor diseases. Today, oral anticoagulants considered equivalent alternatives to low molecular weight heparin (LMWH) guideline‐based treatments of cancer‐associated thromboses. Nevertheless, debates on potential antitumorigenic activities beyond anticoagulation still highly relevant. However, disclosure targeted is complicated by the heterogeneous structure this glycosaminoglycan natural origin. Therefore, synthetic polymers...
The use of anticoagulants in neonates is increasing because the medical advances improving long-term survival very sick infants who are at risk venous thromboembolism (VTE). Current anticoagulation therapy less than ideal, physiological differences compared to children and adults regarding pathophysiology thrombosis pharmacology drug. Limitations associated with conventional have prompted development novel drugs that specifically target key proteins coagulation system. Rivaroxaban first...
Summary Platelets are crucial subcellular elements of haemostasis at sites vascular injury and also known to be immune mediators in pathological thrombosis. Despite the integral role platelets many disease processes, there is very little information available on platelet function response agonists healthy children. We recently reported important differences interaction with monocytes circulation, including increased formation monocyte‐platelet aggregates ( MPA s) without concomitant increase...
Abstract COVID-19 has infected more than 275 million worldwide (at the beginning of 2022). Children appear less susceptible to and present with milder symptoms. Cases children developing clinical features Kawasaki-disease have been described. Here we utilise Mass Spectrometry proteomics determine plasma proteins expressed in healthy pre-pandemic, multisystem inflammatory syndrome (MIS-C) induced ARDS. Pathway analyses were performed affected pathways. 76 are differentially across groups, 85...
Adipokines actuate chronic, low-grade inflammation through a complex network of immune markers, but the current understanding these networks is incomplete. The soluble isoform IL-1 receptor accessory protein (sIL1RAP) occupies an important position in inflammatory pathways involved obesity. pathogenetic and clinical influences sIL1RAP are unknown.The objective study was to elucidate whether plasma levels reduced obesity, using affluent clinical, biochemical, genetic data from two diverse...
Background Remote ischemic preconditioning (RIPC) has been applied in paediatric cardiac surgery. We have demonstrated that RIPC induces a proteomic response plasma of healthy volunteers. tested the hypothesis modifies children undergoing Tetralogy Fallot (TOF) repair. Methods and Results Children (n=40) were randomized to control groups. Blood was sampled at baseline, after cardiopulmonary bypass (CPB) 6, 12 24h post-CPB. Plasma analysed by liquid chromatography mass spectrometry (LC-MS) an...
The Fontan circulation introduces an increased risk of thromboembolism which is associated with substantial mortality and morbidity. Adverse outcomes thromboembolic complications post-Fontan surgery vary in both nature severity, ranging from local tissue infarction pulmonary embolism to failure ischemic stroke. Furthermore, recent studies have identified that subclinical stroke common yet underdiagnosed patients. patients are commonly treated antiplatelet agents and/or anticoagulants as...
OBJECTIVE: To characterize surface-bound proteins and to measure the thickness of fibrin fibers bound extracorporeal membrane oxygenation (ECMO) circuits used in children. DESIGN: Single-center observational prospective study, April November 2021. SETTING: PICU, Royal Children’s Hospital, Melbourne, Australia. PATIENTS: Patients aged less than 18 years on venoarterial ECMO without preexisting disorder. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: were collected from six patients....