A5075719435- Schizophrenia research and treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Pancreatic function and diabetes
- Parkinson's Disease Mechanisms and Treatments
- Pluripotent Stem Cells Research
- RNA regulation and disease
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Nuclear Receptors and Signaling
- Apelin-related biomedical research
- Telomeres, Telomerase, and Senescence
- Nutrition, Genetics, and Disease
- CRISPR and Genetic Engineering
- Adipose Tissue and Metabolism
- Neurological diseases and metabolism
- IL-33, ST2, and ILC Pathways
- Neurofibromatosis and Schwannoma Cases
- Functional Brain Connectivity Studies
- Biochemical Analysis and Sensing Techniques
- Genetics, Aging, and Longevity in Model Organisms
The University of Melbourne
2012-2025
Murdoch Children's Research Institute
2017-2025
Royal Children's Hospital
2012-2024
Baker Heart and Diabetes Institute
2013-2022
Swinburne University of Technology
2015
Deakin University
2007-2011
Caulfield Hospital
2006
Soluble protein hormones are key regulators of a number metabolic processes, including food intake and insulin sensitivity. We have used signal sequence trap to identify genes that encode secreted or membrane-bound proteins in Psammomys obesus, an animal model obesity type 2 diabetes (T2D). Using this trap, we identified the chemokine chemerin as being novel adipokine. Gene expression its receptor, chemokine-like receptor 1 (CMKLR1), was significantly higher adipose tissue obese diabetic P....
Abstract Active breaks in prolonged sitting has beneficial impacts on cardiometabolic risk biomarkers. The molecular mechanisms include regulation of skeletal muscle gene and protein expression controlling metabolic, inflammatory cell development pathways. An active communication network exists between adipose tissue, but the effect tissue have not been investigated. This study characterized acute transcriptional events induced by regular during sitting. We studied 8 overweight/obese adults...
Chemerin is a novel adipokine previously associated with metabolic syndrome phenotypes in small sample of subjects from Mauritius.The aim the study was to determine whether plasma chemerin levels were larger second, unrelated human population.Plasma samples obtained San Antonio Family Heart Study (SAFHS), large family-based genetic epidemiological including 1431 Mexican-American individuals. Individuals randomly sampled without regard phenotype or disease status. This well-characterized for...
Context: Chemerin is a new adipokine associated with obesity and the metabolic syndrome. Gene expression levels of chemerin were elevated in adipose depots obese compared lean animals was markedly during differentiation fibroblasts into mature adipocytes. Objective: The objective study to identify factors that affect regulation potential function using genetics approach. Design, Setting, Patients, Intervention: Plasma measured subjects from San Antonio Family Heart Study, large family-based...
Raloxifene, a selective estrogen receptor modulator (SERM), may improve symptoms and cognition in schizophrenia spectrum disorders (SSD). Studies have shown inconsistent efficacy, especially men with SSD. We assessed whether single nucleotide polymorphisms (SNPs) on genes involved the pharmacodynamics (ESR1 COMT) pharmacokinetics (UGT1A8) of raloxifene can explain heterogeneous treatment response to augmentation patients used subsample participants previously published randomized controlled...
Abstract Background and Hypothesis Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia, yet a significant proportion of individuals on clozapine continue to experience disabling symptoms, despite being treated with an adequate dose. There need adjunct treatments augment clozapine, notably negative cognitive symptoms. One such potential agent glutathione precursor N-acetylcysteine (NAC). Study Design A randomized double-blind, multi-center, placebo-controlled...
Chemerin is a novel protein linked to adipocyte differentiation and the development of metabolic imbalances. We sought examine relationship chemerin with syndrome disturbances including body fat percentage, serum lipid, glucose, insulin levels percentage in lean obese volunteers. A cross-sectional study 90 randomly selected healthy males from Pakistan were divided into three groups as per Body Mass Index (BMI) criteria for South Asian Population. Anthropometric measurements taken BMI, waist...
Although part of the coenzyme A pathway, vanin 1 (also known as pantetheinase) sits on cell surface many types an ectoenzyme, catalyzing breakdown pantetheine to pantothenic acid (vitamin B 5 ) and cysteamine, a strong reducing agent. Vanin was initially discovered protein involved in homing leukocytes thymus. Numerous studies have shown that is inflammation, more recent key role metabolic disease. Here, X-ray crystal structure human at 2.25 Å resolution presented, which first reported from...
Clozapine is an effective treatment for a proportion of people with schizophrenia (SZ) who are resistant to the beneficial effects other antipsychotic drugs. However, anything from 40–60 % on clozapine experience residual symptoms even adequate doses medication, and thus could be considered 'clozapine resistant'. Agents that work alongside improve efficacy whilst not increasing adverse effect burden both desired necessary lives individuals clozapine-resistant SZ. N-Acetylcysteine (NAC) one...
Abstract: We describe the generation and characterization of 5 human induced pluripotent stem cell (iPSC) lines derived from peripheral blood mononuclear cells (PBMCs) healthy adult individuals. The PBMCs were reprogrammed using non-integrating Sendai viruses containing reprogramming factors POU5F1 (OCT4), SOX2, KLF4 MYC. iPSC exhibited a normal karyotype, expressed pluripotency markers differentiated into representative three embryonic germ layers. These can be used as controls in studying...
The aim of this study was to repurpose a drug for the treatment bipolar depression.
The personality characteristics and symptoms observed in schizophrenia are postulated to lie on a continuum, with non-clinical manifestations referred as schizotypy. High schizotypy behaviours argued correspond the three main clusters of schizophrenia: positive, negative cognitive/disorganised symptoms, yet there is limited empirical evidence support this. This study aimed investigate whether dimensions significantly correlate their respective symptomatology largest sample date.A total 361...
Natriuretic peptides are useful for diagnosis and prognostication of heart failure any cause. Now, research aims to discover novel biomarkers that will more specifically define the phenotype. DNA methylation plays a critical role in development cardiovascular disease with potential predict fundamental pathogenic processes. There is lack data relating focuses on patients severe multi-vessel coronary artery disease. To begin address this, we conducted pilot study uniquely exploring utility...
To produce an in vitro model of Bethlem myopathy, we reprogrammed the peripheral blood mononuclear cells (PBMCs) a patient with heterozygous COL6A1 c.1056 + 2T > A mutation at exon/intron 14 boundary gene to induced pluripotent stem (iPSCs). Using CRISPR/Cas9 editing, corrected generate isogenic control line. Both and iPSCs show normal karyotype, express pluripotency markers can differentiate into cell states that represent three embryonic germ layers (endoderm, mesoderm ectoderm). These...
The recent failures of HDL-raising therapies have underscored our incomplete understanding HDL biology. Therefore there is an urgent need to comprehensively investigate metabolism enable the development effective HDL-centric therapies. To identify novel regulators metabolism, we performed a joint analysis human genetic, transcriptomic, and plasma HDL-cholesterol (HDL-C) concentration data identified association between trafficking protein, kinesin binding 2 (TRAK2) HDL-C concentration. Here...
Assessing candidate gene sequence variations and expression helps to understand methamphetamine use disorder inform potential treatments. We investigated single nucleotide polymorphisms (SNPs) in four genes:
South Asians are 1/4 of the world's population and have increased susceptibility to central obesity related cardiometabolic disease. Knowledge genetic variants affecting risk is largely based on genome-wide association studies common SNPs in Europeans. To evaluate contribution DNA sequence variation higher levels (defined as waist hip ratio adjusted for body mass index, WHR) among compared Europeans we carried out: i) a analysis >6M 10,318 with focused population-specific SNPs; ii) an...
Adipokines actuate chronic, low-grade inflammation through a complex network of immune markers, but the current understanding these networks is incomplete. The soluble isoform IL-1 receptor accessory protein (sIL1RAP) occupies an important position in inflammatory pathways involved obesity. pathogenetic and clinical influences sIL1RAP are unknown.The objective study was to elucidate whether plasma levels reduced obesity, using affluent clinical, biochemical, genetic data from two diverse...
Dexamethasone is often administered to surgical patients for anti-emetic prophylaxis. This study examined the early (up 24 h) in-vivo effects of dexamethasone (8 mg) demonstrate magnitude and temporal nature changes on circulating peripheral blood mononuclear cell gene expression activation in 10 healthy male volunteers. Blood samples were drawn at baseline, 2 h, 4 h h. Gene was measured using quantitative real-time polymerase chain reaction. Cytokine multiplex immuno-assays. Innate immune...
Abstract Background Schizophrenia and bipolar disorder are complex mental illnesses that associated with cognitive deficits. There is considerable heterogeneity exists within both disorders. Studies cluster schizophrenia patients into subgroups based on their profile increasingly demonstrate that, relative to healthy controls, there a severely compromised subgroup relatively intact subgroup. emerging evidence telomere shortening, marker of cellular senescence, may be impairments. The aim...