A5066685517- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Gestational Diabetes Research and Management
- Diabetes Management and Education
- Global Public Health Policies and Epidemiology
- Chronic Disease Management Strategies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- SARS-CoV-2 detection and testing
- COVID-19 epidemiological studies
- Diabetes Management and Research
- Pancreatic function and diabetes
- Pregnancy and preeclampsia studies
- Mobile Health and mHealth Applications
- Diabetes Treatment and Management
- Diabetes and associated disorders
- Birth, Development, and Health
- Bariatric Surgery and Outcomes
- Cardiovascular Health and Risk Factors
- Nutritional Studies and Diet
- COVID-19 and healthcare impacts
- Viral Infections and Outbreaks Research
- Thyroid Disorders and Treatments
- Physical Activity and Health
- Epigenetics and DNA Methylation
- Long-Term Effects of COVID-19
Max Super Speciality Hospital
2014-2024
Devki Devi Foundation
2022-2024
Max Healthcare
2012-2023
Institute of Endocrinology
2017-2021
Vigyan Prasar
2018
Delhi Pharmaceutical Science and Research University
2015
An understanding of bone mineral density (BMD) pattern in a population is crucial for prevention and diagnosis osteoporosis management its complications later life. This study aimed to screen the health status factors associated with an apparently healthy Indian population.A retrospective review medical records was done tertiary-care hospital subjects who had undergone preventive health-check-ups that included BMD measurements at femur-neck, total-femur, lumbar-spine.We evaluated 524 (age,...
South Asia has become a major epicentre of the COVID-19 pandemic. Understanding Asians' awareness, attitudes and experiences early measures for prevention is key to improving effectiveness mitigating social economic impacts pandemic responses at critical time Region.
The receptor binding domain (RBD) of SARS-CoV-2 is the primary target neutralizing antibodies. We designed a trimeric, highly thermotolerant glycan engineered RBD by fusion to heterologous, poorly immunogenic disulfide linked trimerization derived from cartilage matrix protein. protein expressed at yield ∼80-100 mg/L in transiently transfected Expi293 cells, as well CHO and HEK293 stable cell lines formed homogeneous disulfide-linked trimers. When lyophilized, these possessed remarkable...
The variability of clinical course and prognosis COVID-19 highlights the necessity patient sub-group risk stratification based on data. In this study, data from a cohort Indian hospitalized patients is used to develop mortality prediction models. We analyzed set 70 parameters including physiological hematological for developing machine learning models identify biomarkers. also compared Wuhan cohort, role steroids. A bootstrap averaged ensemble Bayesian networks was learned construct an...
The modulators of severe COVID-19 have emerged as the most intriguing features SARS-CoV-2 pathogenesis. This is especially true we are encountering variants concern (VOC) with increased transmissibility and vaccination breakthroughs. Microbial co-infections being investigated one crucial factors for exacerbation disease severity complications COVID-19. A key question remains whether early transcriptionally active microbial signature/s in patients can provide a window future susceptibility...
The increasing prevalence of diet-related non-communicable diseases (NCDs) in South Asia is concerning, with type 2 diabetes projected to rise 68%, compared the global increase 44%. Encouraging healthy diets requires stronger policies for healthier food environments.
Co-infection with ancillary pathogens is a significant modulator of morbidity and mortality in infectious diseases. There have been limited reports co-infections accompanying SARS-CoV-2 infections, albeit lacking India specific study. The present study has made an effort toward elucidating the prevalence, diversity characterization co-infecting respiratory nasopharyngeal tract positive patients. Two complementary metagenomics based sequencing approaches, Respiratory Virus Oligo Panel (RVOP)...
In low-middle income countries (LMICs) the role of food environments on obesity has been understudied. We address this gap by 1) examining effect adults' body size (BMI, waist circumference) and obesity; 2) measuring heterogeneity such effects sex. This cross-sectional study analysed South Asia Biobank surveillance environment mapping data for 12,167 adults collected between 2018 2020 from 33 sites in Bangladesh Sri Lanka. Individual-level (demographic, socio-economic, health...
Background: Thyroid storm (TS) is a rare life-threatening condition that characterized by fever and altered mental status precipitated endogenous or exogenous critical events, illness/injury, acute iodine load, thyroid non surgery. A large number of extracts are available extensively used, even though they not recommended clinically in hypothyroid euthyroid patients. Consumption such products can be dangerous result TS. Here, we report case TS caused inadvertent intake very high dosages...
Abstract Background Clinical studies have suggested that depression is common among patients with type 2 diabetes (T2D). Depression an important factor which affects the management and complications of diabetes. However, available data regarding its prevalence in India are limited. Objectives To estimate T2D to compare it a non-diabetic group; determine association glycaemic control T2D. Methods This case–control study was carried out over 5 months from May September 2012 at tertiary care...
Saturation suppressor mutagenesis was used to generate thermostable mutants of the SARS-CoV-2 spike receptor-binding domain (RBD). A triple mutant with an increase in thermal melting temperature ~7°C respect wild-type B.1 RBD and expressed high yield both mammalian cells microbial host, Pichia pastoris , downselected for immunogenicity studies. An additional derivative three mutations from B.1.351 (beta) isolate also introduced into this background. Lyophilized proteins were resistant...
The global epidemic of type 2 diabetes mellitus (T2DM) renders its prevention a major public health priority. A key risk factor is obesity and poor diets. Food environments have been found to influence people's diets obesity, positing they may play role in the prevalence diabetes. Yet, there scant evidence on context low- middle-income countries (LMICs). We examined associations food T2DM among adults heterogeneity by income sex. linked individual outcome data 12,167 individuals from network...
ABSTRACT Objective To describe the clinical profile and factors leading to increased mortality in coronavirus disease (COVID-19) patients admitted a group of hospitals India. Design A records-based study first 1000 with positive result on real-time reverse transcriptase-polymerase-chain-reaction assay for SARS-CoV-2 our facilities. Various such as demographics, presenting symptoms, co-morbidities, ICU admission, oxygen requirement ventilator therapy were studied. Results Of patients, 24...
Oxidative stress has been implicated as a fundamental mechanism in the decline of bone mass. Reactive oxygen species are reported to suppress osteoblast generation and differentiation enhance osteoclast development activity. Increasing evidence suggests favorable effect serum uric acid (UA) on metabolism due its antioxidant properties. Therefore, we investigated association between UA levels mineral density (BMD) healthy adult Indian subjects.We reviewed medical records 524 subjects who had...
INTRODUCTION The International Diabetes Federation (IDF) Atlas estimates that the number of adults with diabetes will rise from 415 to 642 million people by 2040, indicating a substantial increase in living diabetes.[1] India is home second largest (nearly 69.2 people) and children type 1 (T1D) world (70,200), after USA.[2] In addition, millions have impaired glucose tolerance are at increased risk developing T2D future, largely consequence on-going urbanisation increasing life expectancy....
Background and Objective: Incidence of gestational diabetes mellitus (GDM) varies globally from 2% to 14%. These cases in India are also increasing emerging as a major public health problem. The prevalence GDM among urban population has been reported 16% 17.8%, respectively. We conducted this study at three different regions North estimate the GDM. Materials Methods: This pilot prospective cross-sectional was centres with base Max Super Speciality Hospital, Saket, New Delhi, over period 10...
ABSTRACT Background Long-COVID syndrome is now a real and pressing public health concern. We cannot reliably predict who will recover quickly or suffer with mild debilitating long COVID-19 symptoms battle life-threatening complications. In order to address some of these questions, we studied the presence various correlates in patients were discharged from hospital, 3 months up 12 after acute illness. Methods This an observational follow-up study RT-PCR confirmed admitted at hospitals north...