A5073728973- Immune Cell Function and Interaction
- Gestational Diabetes Research and Management
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Cell death mechanisms and regulation
- Systemic Lupus Erythematosus Research
- Immune cells in cancer
- Diabetes and associated disorders
- RNA Interference and Gene Delivery
- Pregnancy and preeclampsia studies
- Cytomegalovirus and herpesvirus research
- Monoclonal and Polyclonal Antibodies Research
- Toxin Mechanisms and Immunotoxins
- Hematopoietic Stem Cell Transplantation
- Rheumatoid Arthritis Research and Therapies
- interferon and immune responses
- Pancreatic function and diabetes
- Bariatric Surgery and Outcomes
- Cancer Immunotherapy and Biomarkers
- Adipokines, Inflammation, and Metabolic Diseases
- Phagocytosis and Immune Regulation
- Birth, Development, and Health
- Glycogen Storage Diseases and Myoclonus
- IL-33, ST2, and ILC Pathways
- Circular RNAs in diseases
Amity University
2016-2024
National Institute of Technology Rourkela
2024
Centre For Human Genetics
2020
Institute of Human Genetics
2020
Rainbow Children's Hospital
2020
Vigyan Prasar
2018
University of California, Los Angeles
2006-2010
International Centre for Genetic Engineering and Biotechnology
2008
Immunovaccine (Canada)
2007
International Centre for Genetic Engineering and Biotechnology
2006
Abstract Systemic lupus erythematosus is a chronic autoimmune disease characterized by loss of tolerance to self-Ags and activation autoreactive T cells. Regulatory (Treg) cells play critical role in controlling the In this study, we investigated mechanisms potential Treg cell defects systemic using MRL-Faslpr/lpr (MRL/lpr) MRL-Fas+/+ mouse models. We found significant increase CD4+CD25+Foxp3+ cells, albeit with an altered phenotype (CD62L−CD69+) reduced suppressive capacity, lymphoid organs...
Background and Objective: Incidence of gestational diabetes mellitus (GDM) varies globally from 2% to 14%. These cases in India are also increasing emerging as a major public health problem. The prevalence GDM among urban population has been reported 16% 17.8%, respectively. We conducted this study at three different regions North estimate the GDM. Materials Methods: This pilot prospective cross-sectional was centres with base Max Super Speciality Hospital, Saket, New Delhi, over period 10...
Survivin has received attention as a potential target for cancer immunotherapy because of its crucial role in oncogenesis. We undertook this study to evaluate the immunotherapeutic combination recombinant survivin along with adjuvant alum and immune modulator Mycobacterium indicus pranii (MIP). In vivo efficacy was studied an invasive murine breast model. Recombinant protein purified from Escherichia coli based expression system characterized by western blotting. Purified combined MIP used...
Aim: Gestational diabetes mellitus (GDM) is a common clinical condition characterized by glucose intolerance of varying severity in the second or third trimester pregnancy. Inflammatory mediators like interleukin-6 (IL-6) and acute phase protein C-reactive (CRP) are supposed to contribute development GDM, however data supporting this hypothesis limited. This study was designed analyze association inflammatory IL-6 CRP with GDM Indian females. Methods: A case control design included pregnant...
To investigate the therapeutic potential of two recombinant proteins, Survivin and luteinizing hormone-releasing hormone (LHRH) fusion protein [LHRH(6leu)-LTB] for immunotherapy breast cancer.Murine 4T-1 cancer model was used to evaluate efficacy proteins in vivo. Twenty four Balb/c mice were divided into 4 groups 6 each. Recombinant LHRH protein, alone or combination, administered along with immunomodulator Mycobacterium indicus pranii (MIP) mice. Unimmunized control group phosphate buffer...
GCK gene variants have been reported to be associated with gestational diabetes mellitus (GDM) in the Caucasian population. There are no reports exploring this association Indian population.This cross-sectional study included subjects from Max Super Speciality Hospital, New Delhi, India, over a span of 6 months. Females diagnosed GDM as per International Association Diabetes and Pregnancy Study Groups (IADPSG) criteria were enrolled. Direct sequencing was performed screen all 10 exons...
The dynamic interplay between tumor cells and immune in the microenvironment plays a crucial role determining disease severity therapeutic outcome cancer. Myeloid are most abundantly available cell population microenvironment. have been shown to exist diverse phenotypes play both antitumoral protumoral roles Understanding biology of myeloid can lay foundation for development strategies aimed at enhancing cells. This article presents an overview various mechanisms by which aid progression....
Rheumatoid factor (RF), Anticyclic citrullinated peptides (Anti-CCP), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) are used as disease markers for RA. There only a few publications elucidating the correlation of DAS-28 with autoantibodies inflammatory markers. In present study, we have made an attempt to determine association among North Indian population. Further, investigated potential subsets in diagnosis Disease activity was calculated by DAS-28-ESR calculator...
Background: Rheumatoid Arthritis (RA) is the most common autoimmune disease. RA can cause permanent deformity and loss of productivity. The primary objective study was to evaluate relationship BMI with Disease Activity Score in patients. secondary presence comorbidities such as diabetes, thyroid, hypertension, periodontitis, pregnancy outcomes (in case females) patients population presented at tertiary healthcare centre. Method: a cross-sectional study. 100 Patients joint clinic were...
Cancer is a heterogeneous group of diseases where abnormal cell growth with potential to invade other body parts takes control normal homeostasis and becomes fatal if not timely rightly treated.There are more than 100 types cancers characterized so far many yet be identified.World Health Organization estimates, that worldwide in 2012 there were 4 million new cancer cases 8.2 related deaths.Amongst various treatment options available for cancer, immunotherapy offers an approach the focus on...