A5018160566- Medical Imaging Techniques and Applications
- Venous Thromboembolism Diagnosis and Management
- Ultrasound in Clinical Applications
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Imaging and Diagnostics
- Medical Imaging and Pathology Studies
- Liver Disease Diagnosis and Treatment
- Radiation Dose and Imaging
- Lymphoma Diagnosis and Treatment
- Mechanical Failure Analysis and Simulation
- Alzheimer's disease research and treatments
- Diet, Metabolism, and Disease
- Acute Kidney Injury Research
- Radiology practices and education
- Lung Cancer Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Lepidoptera: Biology and Taxonomy
- Electrochemical Analysis and Applications
- Orthopedic Infections and Treatments
- Cancer Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Management of metastatic bone disease
- COVID-19 epidemiological studies
- Metabolomics and Mass Spectrometry Studies
- Pancreatic function and diabetes
Saint Louis University
2024
Massachusetts General Hospital
2011-2023
Imperial College London
2010-2023
University of California, San Francisco
1978-2022
Harvard University
2000-2021
Vrije Universiteit Amsterdam
2018
NeuroRx Research (Canada)
2018
Imperial College Healthcare NHS Trust
2011-2018
National Institutes of Health
1993-2015
William James College
2013
Coronary artery disease (CAD) has a significant genetic contribution that is incompletely characterized. To complement genome-wide association (GWA) studies, we conducted large and systematic candidate gene study of CAD susceptibility, including analysis many uncommon functional variants. We examined 49,094 variants in ∼2,100 genes cardiovascular relevance, using customised array 15,596 cases 34,992 controls (11,202 30,733 European descent; 4,394 4,259 South Asian origin). attempted to...
Spheres coated with antibodies specific for myosin were used to detect myocardial cell membrane disruption by scanning electron microscopy. Injury in a population of cultured myocytes was then followed and measured fluorescence-activated sorting. This approach provides unique method quantitating the evolution injury potentially assessing efficacy interventions aimed at protection.
Abstract Aims Chronic noise exposure associates with increased cardiovascular disease (CVD) risk; however, the role of confounders and underlying mechanism remain incompletely defined. The amygdala, a limbic centre involved in stress perception, participates response to noise. Higher amygdalar metabolic activity (AmygA) CVD risk through involving heightened arterial inflammation (ArtI). Accordingly, this retrospective study, we tested whether greater higher: (i) AmygA, (ii) ArtI, (iii) for...
Abstract Aims Activity in the amygdala, a brain centre involved perception of and response to stressors, associates with: (i) heightened sympathetic nervous system inflammatory output (ii) risk cardiovascular disease. We hypothesized that amygdalar activity (AmygA) ratio is among individuals who develop Takotsubo syndrome (TTS), heart failure often triggered by acute stress. tested hypotheses AmygA precedes development TTS those with highest earliest. Methods results Individuals (N=104,...
Abstract The UK and Sweden have among the worst per-capita COVID-19 mortality in Europe. stands out for its greater reliance on voluntary, rather than mandatory, control measures. We explore how timing effectiveness of measures UK, Denmark shaped each country, using a counterfactual assessment: what would impact been, had country adopted others’ policies? Using Bayesian semi-mechanistic model without prior assumptions mechanism or interventions, we estimate time-varying reproduction number...
Rat atrial natriuretic factor (ANF) is translated as a 152-amino acid precursor preproANF. PreproANF converted to the 126-amino proANF, storage form of ANF in atria. isolated from blood approximately 25 amino acids long. It demonstrated here that rat cardiocytes culture store and secrete proANF. Incubation proANF with serum produced smaller peptide. seems be processed atria, appears released into blood, where it by protease
Increases in choline containing metabolites have been associated with a number of disorders, including malignant cell growth. In this study, high resolution magic angle spinning (1)H nuclear magnetic resonance spectroscopy was employed to monitor metabolite changes during transfection, and an increase phosphocholine detected. This appears be correlated membrane disruption the insertion plasmid DNA into cells, since level mock transfected cells comparable that control cells. These data...
Abstract Familial combined hyperlipidemia (FCHL) is a common cause of premature myocardial infarction, but its metabolic basis unknown. Insulin resistance has been suggested in some patients by the presence fasting hyperinsulinemia. We studied insulin action on carbohydrate and fatty acid metabolism FCHL healthy control subjects two-step euglycemic, hyperinsulinemic clamp. During low-dose infusion, steady-state nonesterified acids (NEFAs) were higher than (0.36 mmol/L [95% confidence limits,...
Department of Orthopaedic Surgery, James Whitcomb Riley Hospital for Children, Indiana University School Medicine, Indianapolis.
Neuronatin (Nnat) is an imprinted gene implicated in human obesity and widely expressed neuroendocrine metabolic tissues a hormone- nutrient-sensitive manner. However, its molecular cellular functions precise role organismal physiology remain only partly defined. Here we demonstrate that mice lacking Nnat globally or specifically β cells display impaired glucose-stimulated insulin secretion leading to defective glucose handling under conditions of nutrient excess. In contrast, report no...
Positron Emission Tomography: Basic Science and Clinical PracticeJames A. ScottAudio Available | Share