A5056479676- Cardiac Health and Mental Health
- Cardiac Valve Diseases and Treatments
- Air Quality and Health Impacts
- Cardiovascular Health and Risk Factors
- Noise Effects and Management
- Climate Change and Health Impacts
- Intensive Care Unit Cognitive Disorders
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Obstructive Sleep Apnea Research
- Firm Innovation and Growth
- Esophageal Cancer Research and Treatment
- Neurosurgical Procedures and Complications
- Cardiovascular Syncope and Autonomic Disorders
- Takotsubo Cardiomyopathy and Associated Phenomena
- COVID-19 impact on air quality
- Heart Failure Treatment and Management
- Gastroesophageal reflux and treatments
- Biomarkers in Disease Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Cardiomyopathy and Myosin Studies
- Stroke Rehabilitation and Recovery
- Resilience and Mental Health
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
University of Pittsburgh Medical Center
2025
UPMC Central Pa
2024
Lahey Medical Center
2022-2023
Massachusetts General Hospital
2020-2022
Harvard University
2020-2022
Cardiovascular Research Associates
2021
Alexandria University
2016
Abstract Aims Activity in the amygdala, a brain centre involved perception of and response to stressors, associates with: (i) heightened sympathetic nervous system inflammatory output (ii) risk cardiovascular disease. We hypothesized that amygdalar activity (AmygA) ratio is among individuals who develop Takotsubo syndrome (TTS), heart failure often triggered by acute stress. tested hypotheses AmygA precedes development TTS those with highest earliest. Methods results Individuals (N=104,...
Air pollution [i.e. particulate matter with diameter <2.5 μm (PM2.5)] is a risk factor for major adverse cardiovascular events (MACE). While PM2.5 promotes leucopoiesis and atherosclerotic inflammation in experimental models, it unknown whether this occurs humans. We tested humans (a) associates higher leucopoietic tissue activity arterial (ArtI), (ii) these associations persist after accounting the effects of potential confounders including socioeconomics, traffic noise, factors, (iii)...
<h3>Importance</h3> Long-term disability after stroke is associated with socioeconomic status (SES). However, the reasons for such disparities in outcomes remain unclear. <h3>Objective</h3> To assess whether lower SES larger admission infarct volume and initial accounts association between long-term disability. <h3>Design, Setting, Participants</h3> This cohort study was conducted a prospective, consecutive population (n = 1256) presenting acute ischemic who underwent magnetic resonance...
Background: Chronic exposure to socioeconomic or environmental stressors associates with greater stress-related neurobiological activity (ie, higher amygdalar [AmygA]) and risk of major adverse cardiovascular events (MACE). However, among individuals exposed such stressors, it is unknown whether resilience (NBResilience, defined as lower AmygA despite stress exposure) lowers MACE risk. We tested the hypotheses that NBResilience protects against MACE, does so through decreased bone marrow...
We present a case of transcatheter aortic valve replacement in 70-year-old woman with severe bicuspid stenosis complicated by incomplete recapture the Evolut and buckling delivery system. Our key steps included following: 1) unsuccessful withdrawal buckled system into inline sheath; 2) transradial snaring system, followed traction from both ends to reduce amount buckling; 3) once elongated as much possible, malfunctioning were removed unit over wire. Aortic, iliac, or femoral injury: Reliant...
Introduction and Hypothesis: Chronic psychological stress is strongly linked to cardiovascular disease (CVD) risk. Metabolic activity of the amygdala, a stress-associated brain center, robustly associates with high inflammation CVD We hypothesized that validated polygenic risk score for neuroticism (nPRS), broad trait measure vulnerability stress, independently 1) heightened amygdalar (AmygA) 2) increased myocardial infarction (MI) Methods: Individuals (N=14349; median age (IQR): 64 (52, 74)...
Introduction: A polygenic risk score for coronary artery disease (PRS CAD ) integrates information from many sites of DNA variation into a single metric inherited susceptibility. Heightened metabolic activity the amygdala (AmygA), stress-associated brain center, associates with increases in leukopoietic activity, atherosclerosis and CVD risk. We hypothesized that genes included PRS link to MI part by encoding heightened neurobiological activity. Accordingly, we tested whether CVPRS AmygA as...
Introduction: Obstructive and central sleep apnea (SA) induce fragmentation associates with HTN cardiovascular diseases (CVDs). Sleep is known to increase stress. Further, heightened stress-associated neurobiological metabolism (particularly amygdalar activity - AmygA), potentiates atherosclerosis. However, it unknown: 1) whether SA increases AmygA in humans, or 2) mediates the link between its CV consequences (HTN CVD). Hypothesis: higher which turn hypertension (HTN) myocardial infarction...