A5077339573- Glycosylation and Glycoproteins Research
- Luminescence and Fluorescent Materials
- Nanoparticle-Based Drug Delivery
- Endoplasmic Reticulum Stress and Disease
- Advanced Drug Delivery Systems
- Polymer Surface Interaction Studies
- Biochemical effects in animals
- Sirtuins and Resveratrol in Medicine
- Gold and Silver Nanoparticles Synthesis and Applications
- Bioactive Compounds and Antitumor Agents
- Calcium signaling and nucleotide metabolism
- Quinazolinone synthesis and applications
- Natural Antidiabetic Agents Studies
- Flavonoids in Medical Research
- Anodic Oxide Films and Nanostructures
- Synthesis of heterocyclic compounds
- PARP inhibition in cancer therapy
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Nanoparticles: synthesis and applications
- GDF15 and Related Biomarkers
- Healthcare and Venom Research
- Bacterial Genetics and Biotechnology
- Peptidase Inhibition and Analysis
- Advanced Sensor and Energy Harvesting Materials
- Nanomaterials and Printing Technologies
Griffith University
2018-2024
Menzies School of Health Research
2019
Korea National University of Transportation
2013
Cyclic adenosine diphosphate (ADP)–ribose (cADPR) isomers are signaling molecules produced by bacterial and plant Toll/interleukin-1 receptor (TIR) domains via nicotinamide adenine dinucleotide (oxidized form) (NAD + ) hydrolysis. We show that v-cADPR (2′cADPR) v2-cADPR (3′cADPR) cyclized O-glycosidic bond formation between the ribose moieties in ADPR. Structures of 2′cADPR-producing TIR reveal conformational changes lead to an active assembly resembles those Toll-like adaptor domains....
The NADase SARM1 (sterile alpha and TIR motif containing 1) is a key executioner of axon degeneration therapeutic target for several neurodegenerative conditions. We show that potent inhibitor undergoes base exchange with the nicotinamide moiety adenine dinucleotide (NAD
Thoeris defense systems protect bacteria from infection by phages via abortive infection. In these systems, ThsB proteins serve as sensors of and generate signaling nucleotides that activate ThsA effectors. Silent information regulator SMF/DprA-LOG (SIR2-SLOG) containing effectors are activated cyclic ADP-ribose (ADPR) isomers 2'cADPR 3'cADPR, triggering nicotinamide adenine dinucleotide (NAD
This paper demonstrates the development of pH and thermo‐responsive fluorescent nanoparticles, which are composed graphene oxide (GO) with BODIPY conjugated PEG, to trigger detection cancer cells through imaging based on intracellular accommodation. Responsiveness is studied using atomic force microscopy apparent thickness differences seen changes in pH. Confocal images nanoparticles (NPs) exhibit remarkably bright fluorescence at lysosomal pH, while no observed under a physiological...
Abstract pH and thermo‐responsive graft copolymers are reported where poly( N ‐isopropylacrylamide) [poly(NIPAAm), poly A ], ‐isopropylacrylamide‐ co ‐2‐(diethylamino) ethyl methacrylate) [poly(NIPAAm‐ ‐DEA), B ‐methacrylic acid) ‐MAA), C ] have been installed to benzaldehyde grafted polyethylene glycol (PEG) back bone following introducing a responsive benzoic‐imine bond. All the prepared for PEG‐ g ‐poly(NIPAAm) [ P‐N1 ‐poly(NIPAAm‐ ‐DEA) P‐N2 ‐MAA) P‐N3 were characterized by 1 H‐NMR...
Zwitterionic fluorescent nanoparticles are developed by using polysulfobetaine methacrylate, NIPAAm and BODIPY fluorophores to identify the cancer cells in response intra extracellular stimuli. The exhibit minimal fluorescence intensity at physiological temperature pH, while strong emissions observed acidic basic environments enabling act as novel probes.
Abstract Cyclic ADP ribose (cADPR) isomers are important signaling molecules produced by bacterial and plant Toll/interleukin-1 receptor (TIR) domains via NAD + hydrolysis, yet their chemical structures unknown. We show that v-cADPR (2’cADPR) v2-cADPR (3’cADPR) cyclized O -glycosidic bond formation between the moieties in ADPR. Structures of (2’cADPR)-producing TIR reveal conformational changes required for active assembly resembles those Toll-like adaptor domains, mutagenesis data...
Due to the prevalence of thioamides in antibacterial compounds, we chose convert amide antitubercular compound 2-(decylsulfonyl)acetamide a thioamide using Lawesson’s reagent study its activity against range microorganisms. This derivative (8) had significantly diminished tuberculosis but slightly better than parent Gram positive species Staphylococcus aureus. second major pathogen is remarkable considering structural simplicity these compounds.
Abstract A thermosensitive membrane was prepared through mussel-inspired engineering of anodized aluminum oxide (AAO) membrane. Incorporation catechol-functionalized copolymer having both 2-(dimethylamino)ethyl methacrylate (DMAEMA) and N-isopropylacrylamide (NIPAM) on AAO provided stimuli-response to temperature pH. From the decrease water droplet contact angle buffer solution transport rate above lower critical (LCST) copolymer, a “wettability”-controlled regulation mechanism mass-transfer...
Abstract Glycolipids from Mycobacterium tuberculosis have a profound impact on the innate immune response of host. Macrophage‐inducible C‐type lectin (Mincle) is pattern‐recognition receptor that has been shown to bind trehalose dimycolate (TDM) mycobacterium and instigate intracellular signalling in cell. There are structural similarities between structures TDM phosphatidyl inositol mannoside (PIM). We thus hypothesized these latter might also modulate an similar manner. To test this, we...
Abstract Highly conductive silver (Ag) film on poly(ethylene terephthalate) (PET) substrate was prepared by using room-temperature sinterable nanoparticle (AgNP) ink having TiO2 nanoparticles as photodecomposition catalysts. AgNP-40T (1 wt %) successfully produced Ag with a conductivity up to 5.2% of that bulk silver, after ultraviolet (UV) irradiation for 1 h. The poly(N-vinylpyrrolidone) (PVP) ligands during UV might contribute facile sintering ink.
Abstract Zwitterionic fluorescent polymers (ZFPs) are developed by using poly(sulfobetaine methacrylate), NIPAAm, and BODIPY fluorophores to examine the patterning characteristics based on mussel-inspired surface modification. Water contact angle measurements of ZFP show changes in upon altering pH. The was PDMS stamps imprinted onto a glass substrate, which provided green micropattern under fluorescence microscope, making powerful tool for development useful patterned substrate various applications.