A5055383364- Neuroscience and Neural Engineering
- Advanced Sensor and Energy Harvesting Materials
- Advanced Memory and Neural Computing
- Conducting polymers and applications
- Photoreceptor and optogenetics research
- Muscle activation and electromyography studies
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Wireless Power Transfer Systems
- Modular Robots and Swarm Intelligence
- Retinal Development and Disorders
- Tactile and Sensory Interactions
- Energy Harvesting in Wireless Networks
- Synthesis and properties of polymers
- Ocular Surface and Contact Lens
- Spectroscopy Techniques in Biomedical and Chemical Research
- Non-Invasive Vital Sign Monitoring
- Spacecraft Design and Technology
- 3D Printing in Biomedical Research
- Neurological disorders and treatments
Yonsei University
2021-2025
Institute for Basic Science
2022-2025
Samsung (South Korea)
2000
Abstract Electronic retinal prostheses for stimulating neurons are promising vision restoration. However, the rigid electrodes of conventional implants can inflict damage on soft retina tissue. They also have limited selectivity due to their poor proximity target cells in degenerative retina. Here we present a artificial (thickness, 10 μm) where flexible ultrathin photosensitive transistors integrated with three-dimensional stimulation eutectic gallium–indium alloy. Platinum nanoclusters...
Abstract Tears have emerged as a promising alternative to blood for diagnosing diabetes. Despite increasing attempts measure tear glucose using smart contact lenses, the controversy surrounding correlation between and still limits clinical usage of tears. Herein, we present an in-depth investigation wireless soft lens continuous monitoring glucose. This is capable quantitatively levels in basal tears excluding effect reflex which might weaken relationship with Furthermore, this can provide...
Current soft neural probes are still operated by bulky, rigid electronics mounted to a body, which deteriorate the integrity of device biological systems and restrict free behavior subject. We report soft, conformable interface system that can monitor single-unit activities neurons with long-term stability. The implements in brain, their subsidiary directly printed on cranial surface. high-resolution printing liquid metals forms cellular-scale diameter adaptable lengths. Also, metal-based...
Abstract Electrical stimulation as a therapeutic approach is widely applicable in terms of target tissues or effects. This method can be an alternative to conventional therapies for patients who are resistant drugs ineligible surgical operations. In addition, researchers have actively studied how adjust the parameters electrical order improve effectiveness, many already received treatments with stimulation. With respect devices stimulation, recent studies focused on developing reliability...
Herein, we present an unconventional method for multimodal characterization of three-dimensional cardiac organoids. This can monitor and control the mechanophysiological parameters organoids within a single device. In this method, local pressure distributions human-induced pluripotent stem-cell-derived are visualized spatiotemporally by active-matrix array pressure-sensitive transistors. is integrated with electrodes formed high-resolution printing liquid metal. These liquid-metal inserted...
Conventional power-integrated wireless neural recording devices suffer from bulky, rigid batteries in head-mounted configurations, hindering the precise interpretation of subject's natural behaviors. These power sources also pose risks material leakage and overheating. We present direct printing a system that seamlessly conforms to cranium. A quasi-solid-state Zn-ion microbattery was 3D-printed as built-in source geometrically synchronized shape mouse skull. Soft deep-brain probes,...
Abstract Despite of the substantial potential human‐derived retinal organoids, degeneration ganglion cells (RGCs) during maturation limits their utility in assessing functionality later‐born cell subtypes. Additionally, conventional analyses primarily rely on fluorescent emissions, which detection actual while risking damage to 3D cytoarchitecture organoids. Here, an electrophysiological analysis is presented monitor RGC development early mid‐stage and compare distinct features with...
Abstract The utilization of gallium (Ga)‐based liquid metals (LMs) as functional materials in bioelectronics has been extensively explored over the past decade a key to stimulation biological systems and recording signals. motivation behind this class electronics is driven by opportunities exploit mechanical properties similar tissues. These bioelectronic devices are required maintain functionality under deformation and, especially for implantable applications, should interface with tissues...
For electrocardiogram (ECG) detection, the position of conventional patch-type electrodes based on solid-state metals are difficult to manipulate after attachment and also can lead poor interface with stretchable, rough skin surfaces. Herein, we present a liquid form ECG that be magnetically reconfigured human by providing its conformal interfacing. These consist biocompatible liquid-metal droplets where magnetic particles homogeneously dispersed, their contact yield significantly low...
Stimulating large volumes of neural networks using macroelectrodes can modulate disorder-associated brain circuits effectively. However, conventional solid-metal electrodes often cause unwanted damage due to their high mechanical stiffness. In contrast, low-modulus liquid metals provide tissue-like stiffness while maintaining macroscale electrode dimensions. Here, we present implantable soft made from biocompatible for stimulation. These probes be easily fabricated by simply filling...
Abstract To comprehend the volumetric neural connectivity of a brain organoid, it is crucial to monitor spatiotemporal electrophysiological signals within known as intra-organoid signals. However, previous methods risked damaging three-dimensional (3D) cytoarchitecture organoids, either through sectioning or inserting rigid needle-like electrodes. Also, limited numbers electrodes in fixed positions with non-adjustable electrode shapes were insufficient for examining complex activity...
Abstract Electromyography (EMG) is a widely used diagnostic technique for evaluating the electrical activity of muscles and their controlling nerves. However, conventional surface electrodes with planar structures often suffer from low spatial resolution suboptimal signal quality. Here, 3D‐shaped, substrate‐free, soft, biocompatible liquid metal (LMe) are presented as wearable interface neuromuscular recording. These enable acquisition high‐quality EMG signals while intrinsic mechanical...
Abstract Recently, personalized medical diagnostics and treatments have received significant interest due to the rising demand for reliable, rapid, cost‐effective healthcare services. In recent development of wearable devices, ways engineer devices extend their reliability, minimize risk infection, expand scope application been focused on improving conventional clinical procedures. With increasing in healthcare, substantial because they monitor each physiological parameter specific interest....
Organoids refer to 3D stem cells that have been developed model neurological disorders in vitro. Typically, brain and heart organoids gained interest for their potential truly mimic the functional ability of real organs. Morphological analysis methods using immunostaining slicing are explored extensively over past decade evaluate structures functions organoids. However, destructiveness these limits real‐time monitoring dynamic responses Therefore, electrophysiological with minimally invasive...
Rapid advances in neurotechnology enable bidirectional communication between the nervous system and engineered devices. The precise recording stimulation of typical target neurons by neural interfaces with adequate materials structures can provide revolutionized medical applications, including diagnosis treatment neurological disorders. Thereby, a proper understanding electronic device its interfacing biological surroundings is necessary. Here, this review highlights basic concepts...
Abstract The peripheral nervous system (PNS) is a fascinatingly complex and crucial component of the human body, responsible for transmitting vital signals throughout body's intricate network nerves. Its efficient functioning paramount to our health, with any dysfunction often resulting in serious medical conditions, including motor disorders, neurological diseases, psychiatric disorders. Recent strides science technology have made neuromodulation PNS promising avenue addressing these health...
Implantable bioelectronics capable of electrophysiological monitoring intimately interfacing with biological tissue have provided massive information for profound understanding systems. However, their invasive nature induces a potential risk acute damage, limiting accurate and chronic signals. To address this issue, advanced studies developed effective strategies to engineer the soft, flexible device using preclinical animal models. In addition, optional but innovative approaches improve...
Abstract Fluorinated polyimides with high thermal stability and low optical absorption loss have been investigated for waveguide application. Rib-type waveguides were fabricated using these fluorinated polyimides. Key Words: polyimidesoptical