A5024115656- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Macular Surgery
- Intraocular Surgery and Lenses
- Retinal Development and Disorders
- Ocular Oncology and Treatments
- Vascular Malformations Diagnosis and Treatment
- Cerebral Venous Sinus Thrombosis
- Acute Ischemic Stroke Management
- Corneal surgery and disorders
- Optical Coherence Tomography Applications
- Systemic Lupus Erythematosus Research
- Corneal Surgery and Treatments
- Traumatic Ocular and Foreign Body Injuries
- Mitochondrial Function and Pathology
- Retinopathy of Prematurity Studies
- Ophthalmology and Visual Impairment Studies
- Metabolism and Genetic Disorders
- Connexins and lens biology
- Ocular Infections and Treatments
- Developmental Biology and Gene Regulation
- Photoreceptor and optogenetics research
Severance Hospital
2014-2025
Yonsei University
2016-2025
Gangnam Severance Hospital
2016-2020
National Research Foundation of Korea
2018
Korea Health Industry Development Institute
2018
Manhattan Eye, Ear and Throat Hospital
2016
New York University
2016
Vitreous Retina Macula Consultants of New York
2016
Bayer (United States)
2016
Fistula Foundation
2016
Abstract Electronic retinal prostheses for stimulating neurons are promising vision restoration. However, the rigid electrodes of conventional implants can inflict damage on soft retina tissue. They also have limited selectivity due to their poor proximity target cells in degenerative retina. Here we present a artificial (thickness, 10 μm) where flexible ultrathin photosensitive transistors integrated with three-dimensional stimulation eutectic gallium–indium alloy. Platinum nanoclusters...
Vascular endothelial cell growth factor (VEGF) is strongly induced by oxidative stress in retinal pigment epithelial (RPE) cells, and VEGF-A a survival for various types. This study was conducted to determine whether the autocrine VEGF signaling pathway RPE cells involved mechanism of adaptive response stress.ARPE-19 were treated with hydrogen peroxide, death measured flow cytometry annexin V-fluorescein isothiocyanate. Survival analysis performed pretreatment VEGF-A-neutralizing antibodies,...
Glaucoma causes irreversible vision loss due to optic nerve damage and retinal cell degeneration. Since high intraocular pressure (IOP) is a major risk factor for glaucoma development, accurate IOP measurement crucial, especially intravitreal affecting the optical cells. However, conventional methods have limits in selectively directly detecting local retina pressure. Here, we present continuous measurements of values anterior chamber vitreous living animals using minimally invasive probes...
To report the clinical findings and surgical outcomes of lamellar macular holes (LMHs) with without hole-associated epiretinal proliferation (LHEP).A retrospective review was performed 73 eyes patients who underwent vitrectomy for LMH. Patients were grouped according to presence LHEP on preoperative spectral-domain optical coherence tomography (SD-OCT). Postoperative best-corrected visual acuity (BCVA) OCT features compared between LMH LHEP.Lamellar (LHEP) found in 15 LMHs (20.5%). The mean...
Abstract Despite of the substantial potential human‐derived retinal organoids, degeneration ganglion cells (RGCs) during maturation limits their utility in assessing functionality later‐born cell subtypes. Additionally, conventional analyses primarily rely on fluorescent emissions, which detection actual while risking damage to 3D cytoarchitecture organoids. Here, an electrophysiological analysis is presented monitor RGC development early mid‐stage and compare distinct features with...
<i>Objective:</i> To report the initial experiences with 25-gauge transconjunctival sutureless vitrectomy (TSV) system, including intraoperative and postoperative problems. <i>Methods:</i> We retrospectively reviewed medical records surgical videotapes of 50 consecutive patients who underwent performed by one surgeon using TSV system. <i>Results:</i> Intraoperatively, we encountered such problems as difficulty in inserting microcannula, which led to...
To introduce a tonicity response gene regulator, NFAT (nuclear factor of activated T-cell)-5 and determine its expression mechanism specific roles in human limbal epithelial cell (HLECs) subjected to hyperosmolar stress.NFAT5 was determined various conditions HLECs by RT-PCR Western immunoblot analyses. NFAT5 translocation during stress observed immunocytochemistry. NFAT5-related signal transduction activity measured on the basis inhibition NF-kappaB factor-kappaB), MAPK activity. TNF-alpha...
To describe the pathoanatomy of diabetic macular edema in optical coherence tomography and its correlation with fluorescein angiography patterns.Sixty eyes 56 patients were analyzed. Diabetic was classified into typical focal leakage (from microaneurysm), diffuse (the capillary plexus), or combined/questionable using retinal thickness profiles. The pooling patterns matched to corresponding images analyzed.Focal shows swelling predominantly outer plexiform layer (OPL). Deeply located...
In Brief Purpose: To describe characteristic findings of acute retinal ischemic damage in optical coherence tomography. Methods: Eighteen cases arterial occlusion with available fundus photography, tomography, and/or fluorescein angiography the early phase (<1 month) more than 2 months follow-up were reviewed. A site-to-site analysis between tomography morphology and correlating images done on each visit. Results: Retinal opacities at first presentation vague to mild opacity four eyes,...
To evaluate and compare the effect of silicone oil gas on thickness all retinal layers in eyes with macula-on detachment (RD).Three hundred sixty-seven 367 patients who received tamponade 310 for treatment rhegmatogenous RD were initially reviewed. Automated segmentation method using Spectralis optical coherence tomography was used analysis. The primary outcome measure change each layer central 1 mm zone (silicone vs. tamponade). secondary best-corrected visual acuity at postoperative 6...
To investigate the prevalence of a newly defined drusen type, pachydrusen, soft drusen, and subretinal drusenoid deposits in eyes with polypoidal choroidal vasculopathy fellow relationship between each type thickness, vascular morphology, hyperpermeability.The 169 90 patients were retrospectively reviewed. The was evaluated using color fundus photography optical coherence tomography. thickness presence pachyvessels on tomography hyperpermeability indocyanine green angiography compared among...
Purpose: To investigate the clinical significance of changes in macular microvasculature patients with diabetes mellitus type 2 without diabetic retinopathy. Methods: Fifty-five retinopathy and 48 healthy individuals were enrolled a prospective cross-sectional study. We identified optical coherence tomography angiography parameters (foveal avascular zone [FAZ] area circularity, vessel density, perfusion index) 6 × 6-mm scan. Correlation multiple regression analyses performed between...
Abstract We aimed to investigate the efficacy and safety of primary retropupillary iris claw intraocular lens (R-IOL) implantation in patients with complete (IOL) dislocation. In this single-center retrospective case series, we reviewed medical records who underwent R-IOL surgery pars plana vitrectomy for treatment IOL dislocation between September 2014 July 2019. The outcome was change visual acuity (VA) up 24 months postoperatively. secondary outcomes included changes pressure (IOP),...
Abstract Biomarker tests of Alzheimer’s disease (AD) are invasive and expensive. Recent developments in optical coherence tomography (OCT) OCT angiography (OCTA) have enabled noninvasive, cost-effective characterization retinal layer vasculature thickness. Using OCTA OCT, we characterized microvascular changes the mild cognitive impairment (MCI) stage AD assessed their correlation with structural each neuronal layer. We also evaluated effect APOE-ε4 genotype on microvasculature Retinal...
To report retinal vein occlusion (RVO) and age-related macular degeneration (AMD)-related submacular hemorrhage developing after administration of SARS-CoV-2 vaccines, a single-center, retrospective observational case series was conducted. Clinical data including fundus photographs optical coherence tomography (OCT) scans were reviewed. Twenty-three eyes 21 patients included with the median age at symptom presentation being 77 years (range: 51–85 years). Twelve (52.2%) had 11 (47.8%) RVO....