Ozanimod, a selective sphingosine-1-phosphate receptor modulator, is under investigation for the treatment of inflammatory bowel disease.We conducted phase 3, multicenter, randomized, double-blind, placebo-controlled trial ozanimod as induction and maintenance therapy in patients with moderately to severely active ulcerative colitis. In 10-week period, cohort 1 were assigned receive oral hydrochloride at dose mg (equivalent 0.92 ozanimod) or placebo once daily double-blind manner, 2 received...

Purpose: We compared the efficacy and safety of sodium hyaluronate (SH) carboxymethylcellulose (CMC) in treating mild to moderate dry eye. Methods: Sixty-seven patients with eye were enrolled this prospective, randomized, blinded study. They treated 6 times a day preservative-free unit dose formula eyedrops containing 0.1% SH or 0.5% CMC for 8 weeks. Corneal conjunctival staining fluorescein, tear film breakup time, subjective symptoms, adverse reactions assessed at baseline, 4 weeks, weeks...

Epigallocatechin gallate (EGCG) and curcumin are well known to naturally-occurring anticancer agents. The aim of this study was verify the combined beneficial effects EGCG on PC3 prostate cancer cells, which resistant chemotherapy drugs apoptosis inducers. showed weaker inhibitory effect cell proliferation than two other lines, LNCaP DU145. Co-treatment improved antiproliferative cells. protein expressions p21 were significantly increased by co-treatment curcumin, whereas it not changed...

To report the clinical findings and surgical outcomes of lamellar macular holes (LMHs) with without hole-associated epiretinal proliferation (LHEP).A retrospective review was performed 73 eyes patients who underwent vitrectomy for LMH. Patients were grouped according to presence LHEP on preoperative spectral-domain optical coherence tomography (SD-OCT). Postoperative best-corrected visual acuity (BCVA) OCT features compared between LMH LHEP.Lamellar (LHEP) found in 15 LMHs (20.5%). The mean...

The present study investigated the presence and mechanism of esculin-mediated renoprotection to assess its therapeutic potential. Esculin was orally administered at 20 mg/kg/day for 2 weeks streptozotocin-induced diabetic mice, effects were compared with those vehicle in normal mice. After oral administration esculin concentrations esculetin blood 159.5 ± 29.8 9.7 4.9 ng/mL 30 min, respectively. Food water intake significantly increased mice but attenuated receiving esculin. elevated glucose...

ABSTRACT Background and Purpose: We aimed to evaluate the lactate/albumin ratio (LAR) identify its significance as a prognostic marker for favorable neurologic outcome survival in patients with return of spontaneous circulation after out-of-hospital cardiac arrest (OHCA). Based on LAR multiple parameters, we developed new nomograms externally validated tools. Methods: conducted an observational study using prospective, multicenter registry out-of-cardiac resuscitation provided by Korean...

With the increase of adult orthodontic population, there is a need for an accurate and evidence-based prediction posttreatment face in 3 dimensions (3D). The objectives this study are 1) to develop 3D postorthodontic method based on deep learning network using patient-specific factors treatment conditions 2) validate accuracy clinical usability proposed method. Paired sets ( n = 268) pretreatment (T1) (T2) cone-beam computed tomography (CBCT) patients were trained with conditional generative...

Purpose: To evaluate changes in clinical outcomes, inflammatory cytokine levels, and tear osmolarity the tears of patients with moderate to severe dry eye syndrome before after application topical 1% methylprednisolone.Materials Methods: Thirty-two unresponsive previous aqueous enhancement therapy were enrolled.Five lost follow up, twenty-seven eligible for analysis.Patients instructed apply methylprednisolone four times per day, as well continue applying their current preservative-free 0.1%...

Purpose:The purpose of this study is to identify risk factors for severe thyroid-associated orbitopathy (TAO) and compressive optic neuropathy in Korean patients.Methods: This was a retrospective comparative case series.All TAO patients who were first seen at our institution between 2005 2009 had follow-up periods least 6 months included.Patients divided into mild or moderate groups.Cases also segregated based on the presence absence neuropathy.Demographics, smoking status, comorbidities,...

We aimed to determine whether emergency department (ED) overcrowding affects the occurrence of in-hospital cardiac arrest (IHCA) requiring resuscitation in ED. This retrospective study was conducted ED a single hospital. applied propensity score-matching method adjust for differences clinical characteristics patients who visited during overcrowded conditions. The indicators were: total number patients, undergoing treatment, and boarded awaiting hospital admission at time patient’s arrival....

To compare the short-term therapeutic efficacy of oral spironolactone treatment with that half-dose photodynamic therapy (PDT) in patients nonresolving central serous chorioretinopathy.This retrospective, interventional, comparative study included 41 chorioretinopathy who exhibited subretinal fluid accumulation for more than 3 months. Of patients, 18 (18 eyes) received and 23 (23 PDT. Treatment outcomes, including macular thickness, height, subfoveal choroidal best-corrected visual acuity,...

Obesity is an important and preventable risk factor for renal disease. The administration of antioxidant with a lipid-lowering effect therapeutic approach kidney disease in obese patients. present study was conducted to examine whether methanolic extract Dendrobium moniliforme (DM), one the most famous traditional medicines used many parts world, has vitro ameliorative on high-fat diet (HFD)-induced alterations such as dysfunction lipid accumulation vivo. 1,1-diphenyl-2-picrylhydrazyl...

To describe the clinical characteristics associated with a newly identified mutant of autosomal recessive bestrophinopathy (ARB) and confirm physiological functional defects.Two patients ARB from one family underwent full ophthalmic examination, including dilated fundus photography, fluorescein angiography, autofluorescence imaging, spectral-domain optical coherence tomography (OCT), electroretinography (ERG), electrooculography (EOG). Subsequently, genetic analysis for bestrophin-1 (BEST1)...

Abstract Adult-onset vitelliform macular dystrophy (AVMD) is a common and benign degeneration which can be caused by BEST1 mutation. Here, we investigated the clinical characteristics associated with newly identified mutation, p.Ile38Ser confirmed physiological functional defects. The 51-year-old patient presented bilateral small subretinal yellow deposits. Consistent AVMD, corresponding lesions showed hyperautofluorescence, late staining in fluorescein angiography, hyper-reflective...

This study investigated factors associated with chorioretinal atrophy (CRA) progression in myopic choroidal neovascularization (CNV) after anti-vascular endothelial growth factor therapy.Fifty eyes of 50 treatment-naive patients CNV who underwent monotherapy at least 2 years follow-up data were included. The cumulative occurrence CRA was assessed using a Kaplan-Meier analysis. Demographic and clinical characteristics including macular thickness various areas compared between without...

Abstract Background This study aimed to examine the characteristics of older adults patients who suffered a head injury after ground-level fall in comparison non-head as well factors associated with severity those only. Methods Patients were classified into two groups, group and group. The compared evaluated. Factors relating severe also investigated. Results comprised 42 % subjects. Male sex; time 18:00–23:59; location medical facility, transportation area, public or commercial facility; an...

Early identification of patients at risk potential death and timely transfer to appropriate healthcare facilities are critical for reducing the number preventable trauma deaths. This study aimed establish a cutoff value predict in-hospital mortality using reverse shock index multiplied by Glasgow Coma Scale (rSIG).

Retinal hemorrhage is a frequently observed sign in Plasmodium falciparum infection. In vivax infection, however, retinal very rare; only five cases have been reported the literature. this case report, we review literature and of 52-year-old man who had hemorrhages P. We analyzed structural characteristics lesions using fluorescein angiography spectral-domain optical coherence tomography. Physicians should be aware possibility malaria patients, even those with consider diagnosis patient...

To evaluate the incidence and risk factors of contrast-induced nephropathy (CIN) in patients undergoing fluorescein angiography (FA). One hundred sixty who underwent FA as a part ophthalmic examination had serum creatinine (SCr) results within 24 h before 72 after between 2005 2013 at tertiary medical center were included. According to baseline SCr levels, subjects divided into low-risk group (<1.5 mg/dL), intermediate-risk (1.5–2.0 high-risk (>2.0 mg/dL) for CIN development. The incidence,...

Purpose: To evaluate the efficacy of photodynamic therapy using a double dose verteporfin for patients with circumscribed choroidal hemangioma. Methods: This retrospective comparative case series evaluated data from 10 who were treated (12 mg/m 2 ) and seven standard (6 ). A laser was applied radiant exposure 50 J/cm . The ophthalmologic examinations performed at baseline 1 year after treatment included best-corrected visual acuity, slit-lamp biomicroscopy, fundus examination, spectral...

Estrogen replacement therapy is a treatment to relieve the symptoms of menopause. Many studies suggest that natural bioactive ingredients from plants resemble estrogen in structure and biological functions can The fruit