Branch retinal vein occlusion (BRVO) is a leading cause of visual impairment in working-age individuals, though predicting its occurrence from vascular features alone remains challenging. We developed deep learning model to predict BRVO based on pre-onset, metadata-matched fundus hemisection images. This retrospective cohort study included patients diagnosed with unilateral two Korean tertiary centers (2005–2023), using images 27 BRVO-affected eyes paired 81 unaffected hemisections (27...

Transcriptional factor nuclear factor-kappaB (NF-κB) plays a crucial role in human breast cancer cell invasion and metastasis. The carboxyl terminus of Hsc70-interacting protein (CHIP) is U-box-type ubiquitin ligase that induces ubiquitination proteasomal degradation its substrate proteins. In this study, we investigated the CHIP NF-κB pathway MDA-MB-231 cells, highly aggressive line. We showed overexpression significantly inhibits cells. suppressed expression urokinase plasminogen activator...

Several in vivo studies have found that transplanting mesenchymal stem cells (MSCs) into degenerative intervertebral discs (IVDs) leads to regeneration of disc cells. Since the exact underlying mechanisms are not understood, we investigated action MSCs IVDs via paracrine actions. Human and from same donor vertebrae were directly or indirectly cocultured. The multidifferentiation potential, cell proliferation, collagen synthesis, mRNA expression levels assessed. proliferation rates higher...

Purpose: To investigate the clinical significance of changes in macular microvasculature patients with diabetes mellitus type 2 without diabetic retinopathy. Methods: Fifty-five retinopathy and 48 healthy individuals were enrolled a prospective cross-sectional study. We identified optical coherence tomography angiography parameters (foveal avascular zone [FAZ] area circularity, vessel density, perfusion index) 6 × 6-mm scan. Correlation multiple regression analyses performed between...

Abstract We aimed to investigate the efficacy and safety of primary retropupillary iris claw intraocular lens (R-IOL) implantation in patients with complete (IOL) dislocation. In this single-center retrospective case series, we reviewed medical records who underwent R-IOL surgery pars plana vitrectomy for treatment IOL dislocation between September 2014 July 2019. The outcome was change visual acuity (VA) up 24 months postoperatively. secondary outcomes included changes pressure (IOP),...

Abstract Biomarker tests of Alzheimer’s disease (AD) are invasive and expensive. Recent developments in optical coherence tomography (OCT) OCT angiography (OCTA) have enabled noninvasive, cost-effective characterization retinal layer vasculature thickness. Using OCTA OCT, we characterized microvascular changes the mild cognitive impairment (MCI) stage AD assessed their correlation with structural each neuronal layer. We also evaluated effect APOE-ε4 genotype on microvasculature Retinal...

Background/Objectives: Retinal vein occlusion (RVO) is a major cause of vision loss globally. Although magnesium (Mg) crucial for vascular health, its association with RVO risk unknown. Thus, we aimed to further examine this association. Methods: This cross-sectional study included participants the Korean National Health and Nutrition Examination Survey 2017-2021 aged ≥19 years (n = 16,358). diagnosis was based on fundus imaging or self-reported. Based their daily Mg intake, categorized into...

Serine/threonine kinase NIMA-related 2 (NEK2) plays a crucial role in regulating the cell cycle and DNA damage response. This study explored mechanisms by which NEK2 inhibition affects porcine embryonic development. To explore of development, we used inhibitor JH295 AKT activator SC79. Various staining methods, including EdU, EU, OPP, TUNEL assay, real-time PCR, immunocytochemistry, Western blotting, were to identify effects on developmental competence, damage, related embryos. significantly...

Insulin-like growth factor 1 (IGF-1) influences various aspects of embryogenesis, including embryonic development. This study investigated the effects IGF-1 on early development in pig embryos, focusing its interaction with Wnt/β-catenin signaling pathway, a key regulator cell adhesion and proliferation. Porcine embryos were used for experiments chemical treatments to blastocyst underlying mechanism. Apoptosis, immunochemistry, gene expression, protein quantification performed, statistical...

Lamellar microdomain orientation in polystyrene-b-poly(methyl methacrylate) (PS-b-PMMA) films was controlled by a solvent vapor annealing process, where the high-molecular-weight block copolymer (BCP) used to self-assemble large period of 105 nm. A neutral with tetrahydrofuran screened difference surface energy between two blocks and interfacial interactions substrate each block, leading substrate-independent perpendicular lamellar microdomains. Together thermal solvent-annealed BCP film, we...

To investigate the efficacy, safety, and anatomical outcomes associated with intravitreal anti-vascular endothelial growth factor (VEGF) treatment of retinopathy prematurity (ROP).

The functional role of Langerhans cells (LCs) in ocular surface inflammation and nerve damage dry eye (DE) disease has yet to be determined. This study was performed investigate this relationship through both clinical on DE patients vivo mouse models with induced disease. In a cross-sectional case-control (54 eyes patients; 34 control patients), average cell density, area, process length LCs were measured using confocal microscopy. Data analyzed determine whether changes are correlated...

Adiponectin, an adipokine, has been described as showing physiological benefits against obesity-related malfunctions and vascular dysfunction. Several natural compounds that promote the expression secretion of adipokines in adipocytes could be useful for treating metabolic disorders. This study investigated effect fisetin, a dietary flavonoid, on regulation adiponectin using 3T3-L1 preadipocytes. The increased cells upon treatment with fisetin dose-dependent manner. Fisetin-induced was...

Purpose: To investigate the effects of resveratrol on expression hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth (VEGF) in human adult retinal pigment epithelial (ARPE-19) cells, experimental choroidal neovascularization (CNV) mice.Materials Methods: ARPE-19 cells were treated with different concentrations then incubated under hypoxic conditions subsequent evaluation cell viability, HIF-1α, VEGF.The synthesis degradation hypoxia-induced HIF-1α evaluated using inhibitors...

Abstract We analysed the imaging findings of macular telangiectasia (MacTel) type 2 in Korea using spectral domain optical coherence tomography (SD-OCT) and investigated their relationship with visual acuity clinical stages. A retrospective multicentre cross-sectional study was conducted six tertiary hospitals included 129 patients. all SD-OCT images encompassing area. Hyporeflective cavities (77.7%) were most frequently detected abnormalities SD-OCT. Disruption external limiting membrane,...

To compare the efficacy, anatomical outcomes and complications of intravitreal ranibizumab with those laser photocoagulation for retinopathy prematurity (ROP).This is a retrospective case series 314 eyes from 165 infants diagnosed type I ROP treated either (161 eyes) or (0.25 mg/0.025 mL) injection (153 between January 2006 December 2016 in tertiary referral-based hospital. The main outcome was rate recurrence requiring additional treatment. Secondary included incidence major final...

Purpose: The aim of this study was to evaluate whether perivascular space (PVS) severity and retinal ganglion cell layer (GCL) thickness differed based on the stage diabetic retinopathy (DR) cognitive status in patients with DR. Methods: A total 81 DR (51 non-proliferative group 30 proliferative group) were included retrospective, cross-sectional study. PVS assessed basal ganglia (BG) centrum semiovale using MRI. cerebral small vessel disease (SVD) score determined numbers lacunes...

Background To characterise the contrast sensitivity function (CSF) in central serous chorioretinopathy (CSCR) compared with healthy controls using novel computerised (CS) testing active learning algorithms. Methods Prospective observational study measuring CSF CSCR eyes and Manifold Platform (Adaptive Sensory Technology, San Diego, California). Mixed effects multivariate regression models were used. Outcomes included area under log (AULCSF), CS thresholds at 1, 1.5, 3, 12 18 cycles per...

Purpose: To determine the diagnostic potential of next-generation sequencing (NGS) in vitreous samples, analyze genotype-phenotype characteristics, and compare NGS matched brain samples patients with associated central nervous system lymphoma (CNSL). Methods: A total 32 suspected vitreoretinal (VRL) who underwent vitrectomy were included this retrospective observational case-series. Fresh specimens from VRL-suspected using a custom panel targeting 747 candidate genes for lymphoma. They also...

Purpose: Necrotizing viral retinitis is a serious eye infection that requires immediate treatment to prevent permanent vision loss. Uncertain clinical suspicion can result in delayed diagnosis, inappropriate administration of corticosteroids, or repeated intraocular sampling. To quickly and accurately distinguish between noninfectious retinitis, we aimed develop deep learning (DL) models solely using noninvasive blood test data. Methods: This cross-sectional study trained DL common serology...

To identify significant fluorescein angiographic (FA) characteristics associated with visual acuity (VA) in Behçet retinal vasculitis.Retrospective review of 86 eyes 48 patients (age: 35.6±10.2 years) vasculitis were performed. VA and FA findings as well correlation between them assessed.The mean initial posterior pole-involved (63 eyes; 73.3%) was significantly worse than that those peripheral (23 eye; 26.7%) (logarithm the minimum angle resolution VA: 0.554±0.572 vs. 0.078±0.148;...

Abstract Central serous chorioretinopathy (CSC), characterized by detachment of the macular retina, can cause permanent vision loss in chronic course. Chronic CSC is generally treated with photodynamic therapy (PDT), which costly and quite invasive, results are unpredictable. In a retrospective case–control study design, we developed two-stage deep learning model to predict 1-year outcome PDT using initial multimodal clinical data. The training dataset included 166 eyes an additional...